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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris M C Chaloin L Mery J | 1999 | Nucleic Acids Res1999，27，17： | 1 |
| 4 | The course of lupus nephritis:contribution of serial renal biopsies显示文摘 | Morel-Maroger L Mery JP Droz D | 1976 | Adv Nephrol1976，6，： | 1 |
| 5 | Single crystal modeling ofstructural calculations : partl-model presentation 显示文摘 | Merie L Poubanlie P Cailletaud G | 1991 | ASME Journalof Engineering Material and Technology1991，113，： | 1 |
| 6 | Overexpression of CRT increases intraeellular Ca2+ storage and decreases storeoperated Ca2+ influx显示文摘 | MERY L MESAELI N MICHALAK M | 1996 | J Biol Chem1996，271，6： | 1 |
| 7 | Topical effectiveness of molgramostim (GM-CSF) in sickle cell leg ulcers 显示文摘 | Mery L Girot R Aractingi S | 2004 | Dermatology2004，208，2： | 1 |
| 8 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris MC Chaloin L Mery J | | 0，，17： | 1 |
| 9 | Follicular growth in vitro: detection of growth differentiation factor 9 (GDFg) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices显示文摘 | Mery L Lefevre A Benchaib M | 2007 | Mol Reprod Dev2007，74，6： | 1 |
| 10 | The N-terminal domain of the type 1 Ins (1, 4, 5) P3 receptor stably expressed in MDCK cells interacts with myosin IIA and alters epithelial cell morphology 显示文摘 | Hours MC Mery L | 2010 | J Cell Sci2010，123，9： | 1 |
| 11 | Overexpression of CRT increases intracellular Ca^2+ storage and decreases store - operated Ca^2+ influx显示文摘 | Mery L Mesaeli N Michalak M | 1996 | J Biol Chem1996，271，16： | 1 |
| 12 | An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an ontario farm population显示文摘 | ARBUCKLE T E LIN Z MERY L S | 2001 | Environ Health Perspect2001，109，8： | 1 |
| 13 | Serum complement and familial combined hyperlipidemia显示文摘 | Ylitalo K Porkka KV Meri S Nuotio I Suurinkeroinen L Vakkilainen J | 1997 | Atherosclerosis1997，129，2： | 1 |
| 14 | Evalu- ating the Absorption of Boron by Plants--A Potential Tool to Remediate Contaminated Sediments from Cecina River Basin in Italy 显示文摘 | Eliana L Tassi Francesca Pedron Meri Barbafieri | 2011 | Water Air & Soil Pollution2011，216，14： | 1 |
| 15 | From Simple Monopyridine Clusters and Hexapyridine Clusters 4 (X= Br or I) to Cluster-Cored Organometallic Stars, Dendrons, and Dendrimers 显示文摘 | Mery D Plault L Ornelas C | 2006 | Inorg Chem2006，45，： | 1 |
| 16 | Absence of fetal cell microchimerism in cutaneous lesions of lupus erythematosus显示文摘 | Khosrotehrani K Mery L Aractingi S | 2005 | Ann Rheum Dis2005，64，： | 1 |
| 17 | Follicular growth in vitro: detection of growth differentiation factor 9 ( GDF9 ) and bone morphogenetic protein 15 ( BMP15 ) during in vitro culture of ovine cortical slices 显示文摘 | Mery L Lefevre A Benchaib M | 2007 | Mol Reprod Dev2007，74，6： | 1 |
| 18 | Follicular growth in vitro: detection of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices显示文摘 | Mery L Lefevre A Benchaib M | 2007 | Mol Reprod Dev2007，74，6： | 1 |
| 19 | Use of chitosan solutions for the microbiological shelf life extension of papaya fruits during storage at room temperature 显示文摘 | Guilherme L Mery L G Luiz A A | 2015 | LWT-Food Science and Technology2015，64，1： | 1 |
| 20 | Risk of stroke after coronary ar- tery bypass grafting: effect of age and comorbidities显示文摘 | Merie C Kober L Olsen PS | 2012 | Stroke2012，43，1： | 1 |
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