|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Complement activation in diseases presen- ting with thrombotic microangiopathy显示文摘 | MERI S | 2013 | Eur J In- tern Med2013，24，： | 1 |
| 3 | Potent andspecific geneticinterference by doubl estranded RNA in Caenorhabitis elegans显示文摘 | Fire A Xu S Montgo mery MK et a 1 | 1998 | Nature1998，301，6669： | 1 |
| 4 | Topical effectiveness of molgramostim (GM-CSF) in sickle cell leg ulcers 显示文摘 | Mery L Girot R Aractingi S | 2004 | Dermatology2004，208，2： | 1 |
| 5 | Nasal toxicity of chloroform in male F-344 rats and female B6C3F1 mice following a 1-week inhalation exposure 显示文摘 | Mery S Larson JL Butterworth BE | 1994 | Toxicol Appl Pharmacol1994，125，： | 1 |
| 6 | Co-deposition of clusterin with the complement membrane attack complex in myocardial infarction显示文摘 | Vakeva A Laurila P Meri S | 1993 | Immunology1993，80，： | 1 |
| 7 | Immune evasion of tumor cells using membrane- bound complement regulatory proteins显示文摘 | Gorter A Meri S | 1999 | lmmunol Today1999，20，12： | 1 |
| 8 | IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression 显示文摘 | Tissari J Siren J Meri S | 2005 | J Immunol2005，174，7： | 1 |
| 9 | A multiwindow approach for radargrammetrie improvements 显示文摘 | Merie S Fayard F Pottier E | 2011 | IEEE Transactions on Geoseience and Remote Sensing2011，49，10： | 1 |
| 10 | Human protectin (CD59), an 18,000 - 20,000MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers 显示文摘 | Meri S Morgan BP Davies A | 1990 | Immunology1990，71，1： | 1 |
| 11 | Inflammasome-essential regulator ofthe inflammatory reaction 显示文摘 | Junttila I Meri S Ramet M | 2013 | Duodecim2013，129，7： | 1 |
| 12 | IFN-αEnhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial Cells by up-regulating TLR3 expression显示文摘 | Tissari J Siren J Meri S | 2005 | J Immunol2005，174，7： | 1 |
| 13 | Cerebral revascular- ization using cadaveric vein grafts显示文摘 | MERY FJ Amin-Hanjani S Charbel FT | 2009 | Surg Neurol2009，72，4： | 1 |
| 14 | Elevated levels of the complement regulator protein CD59 in severe acute pancreatitis 显示文摘 | Lindstrom O Jarva H Meri S | 2008 | Scand J Gastroenterol2008，43，3： | 1 |
| 15 | Func- tion and regulation of the complement system in cardi- ovascular diseases 显示文摘 | OKSJOKI R KOVANEN P T MERI S | 2007 | Front Biosci2007，12，： | 1 |
| 16 | Immune evasion of tumor cell using membrane-bound complement regulatory proteins显示文摘 | Gorter A Meri S | | 0，，12： | 1 |
| 17 | Cerehral revasculari?zation using cadaveric vein grafts显示文摘 | Mery FJ Amin-Hanjani S Charbel FT | 2009 | Surg Neurol2009，72，4： | 1 |
| 18 | Human protectin(CD59), an 1 8 000-20 000 MW complement lysis restricting factor, inhibits C5b- 8 catalysed insertion of C9 into lipid bilayers 显示文摘 | Meri S Morgan BP Davies A | 1990 | Immunology1990，71，1： | 1 |
| 19 | Dificiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease显示文摘 | Yang LB Li R Meri S | | 0，，20： | 1 |
| 20 | IFN -alpha enhances TLR3 -mediated antiviral cytokine exF: esson in human endothelial and epithelial cells by up -regulating TLR3 expression 显示文摘 | TISSARI J SIREN J MERI S | 2005 | J }mmunol2005，174，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员