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| 1 | Effects of lanthanum and gadolinium on proliferation and differentiation of primary osteoblasts显示文摘增长,区别和老鼠 calvarial os-teoblast-like 房间的 adipogenic transdifferentiation 上的 La 3+ 和 Gd 3+ 的效果(抢劫房间) 被 MTT 方法评估,测量碱的磷酸酶(高山) 和油红 O 测量的活动。两个都, La, 3+ 和 Gd 3+ 禁止了增长根本抢劫房间集中(110 -5, 110 -6, 110 -7, 110 -8, 110 -9 摩尔 L -1, 。在 110 -5 摩尔的集中的 La 3+ , L -1 显著地增加了碱的磷酸酶活动抢劫房间直到 3 褶层,(P<0.01 ) 。然而,效果逆行在另外的集中禁止。Gd 3+ 在碱的磷酸酶活动起了一个否定作用。La 3+ 禁止了 adipogenic transdifferentiation 根本抢劫房间以一个剂量依赖者方法的集中。然而, Gd 3+ 支持了 adipogenic transdifferentiation 在 110 -8 和 110 -9 摩尔 L -1 抢劫房间。这些调查结果建议增长,区别和 adipogenic transdifferentiation 上的稀土元素元素的效果抢劫细胞依赖于他们的集中和种。 | Zhang Dawei Zhang Jinchao Chen Yao Yang Mengsu Yao Xinsheng | 2007 | Progress in Natural Science:Materials International2007，17，5： | 6 |
| 2 | Effect of Dy^(3+) on osteogenic and adipogenic differentiation of mouse primary bone marrow stromal cells and adipocytic trans-differentiation of mouse primary osteoblasts显示文摘A series of experimental methods including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bro-mide (MTT) test,alkaline phosphatase (ALP) activity measurement,mineralized function,Oil Red O stain and measurement were employed to assess the effect of Dy3+ on the osteogenic and adipogenic differentiation of mouse primary bone marrow stromal cells (BMSCs) and the adipogenic trans-differ-entiation of mouse primary osteoblasts (OBs). The results showed that Dy3+ had no effect on BMSC proliferation at concentrations of 1×10-8 and 1×10-5 mol/L,but inhibited BMSC proliferation at other concentrations. Dy3+ had no effect on OB proliferation at concentrations of 1×10-10 and 1×10-9 mol/L,but inhibited OB proliferation at other concentrations. Dy3+ had no effect on the osteogenic differentia-tion of BMSCs at concentrations of 1×10-9 and 1×10-7 mol/L,and promoted osteogenic differentiation of BMSCs at other concentrations at the 7th day. The osteogenic differentiation of BMSCs was inhibited by Dy3+ at concentration of 1×10-5 mol/L at the 14th day,but promoted osteogenic differentiation of BMSCs at concentrations of 1×10-9,1×10-8,1×10-7 and 1×10-6 mol/L with the maximal effect at concen-tration of 10-6 mol/L. Dy3+ promoted mineralized function of BMSCs at any concentration. Dy3+ had no effect on adipogenic differentiation of BMSCs at concentration of 1×10-7 mol/L,but inhibited adipogenic differentiation of BMSCs at other concentrations. Dy3+ inhibited adipocytic trans-differentiation of OBs at any concentration,suggesting that Dy3+ had protective effect on bone and the protective effect on bone may be mediated by modulating differentiation of BMSCs away from the adipocyte and inhibiting adipocytic trans-differentiation of OBs which may promote differentiation and mineralization of OBs. These results may be valuable for better understanding the mechanism of the effect of Dy3+ on pathogenesis of osteoporosis. | ZHANG JinChao LIU DanDan SUN Jing ZHANG DaWei SHEN ShiGang YANG MengSu | 2009 | Chinese Science Bulletin2009，54，1： | 6 |
| 3 | Effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of bone marrow stromal cells and on the adipogenic trans-differentiation of osteoblasts显示文摘The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), alkaline phosphatase (ALP) activity and oil red O assays were used to examine the effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells (MSCs) and the adipogenic trans-differentiation of primary mouse osteoblasts. The results indicated that daidzein, genistein and glycitein at concentrations from 1×10 -8 mol/L to 1×10 -5 mol/L promoted the proliferation of MSCs and osteoblasts; genistein, daidzein and glycitein promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs, and inhibited adipocytic transdifferentiation of osteoblasts at appropriate concentrations as 17β-estradiol. It suggests that genistein, daidzein and glycitein regulate a dual differentiational process of MSCs into the osteogenic and adipogenic lineages, and trans-differentiational process of primary osteoblasts into the adipocyte lineages, causing a lineage shift toward osteoblast. Protective effects of them on bone may be mediated by a reversal of adipogenesis which may promote the proliferation, differentiation and mineralization of osteoblasts, and make adipocytes secrete less cytokines which may promote osteoclast formation and activation. In addition, the results also indicated that genistein, daidzein and glycitein may be helpful in preventing the development of steroid induced osteonecrosis. | LI Xianghui ZHANG Jinchao SUI Senfang YANG Mengsu | 2005 | Progress in Natural Science:Materials International2005，15，11： | 5 |
| 4 | Numerical manifold method modeling of coupled processes in fractured geological media at multiple scales显示文摘The greatest challenges of rigorously modeling coupled hydro-mechanical(HM)processes in fractured geological media at different scales are associated with computational geometry.These challenges include dynamic shearing and opening of intersecting fractures at discrete fracture scales as a result of coupled processes,and contact alteration along rough fracture surfaces that triggers structural and physical changes of fractures at micro-asperity scale.In this paper,these challenges are tackled by developing a comprehensive modeling approach for coupled processes in fractured geological media based on numerical manifold method(NMM)at multiple scales.Based on their distinct geometric features,fractures are categorized into three different scales:dominant fracture,discrete fracture,and discontinuum asperity scales.Here the scale is relative,that of the fracture relative to that of the research interest or domain.Different geometric representations of fractures at different scales are used,and different governing equations and constitutive relationships are applied.For dominant fractures,a finite thickness zone model is developed to treat a fracture as a porous nonlinear domain.Nonlinear fracture mechanical behavior is accurately modeled with an implicit approach based on strain energy.For discrete fractures,a zero-dimensional model was developed for analyzing fluid flow and mechanics in fractures that are geometrically treated as boundaries of the rock matrix.With the zero-dimensional model,these fractures can be modeled with arbitrary orientations and intersections.They can be fluid conduits or seals,and can be open,bonded or sliding.For the discontinuum asperity scale,the geometry of rough fracture surfaces is explicitly represented and contacts involving dynamic alteration of contacts among asperities are rigorously calculated.Using this approach,fracture alteration caused by deformation,re-arrangement and sliding of rough surfaces can be captured.Our comprehensive model is able to handle the computational challenges with accurate representation of intersections and shearing of fractures at the discrete fracture scale and rigorously treats contacts along rough fracture surfaces at the discontinuum asperity scale.With future development of three-dimensional(3D)geometric representation of discrete fracture networks in porous rock and contacts among multi-body systems,this model is promising as a basis of 3D fully coupled analysis of fractures at multiple scales,for advancing understanding and optimizing energy recovery and storage in fractured geological media. | Mengsu Hu Jonny Rutqvist | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，4： | 4 |
| 5 | MRI结合数字化钼靶诊断乳腺癌的临床研究(英文)显示文摘目的将在乳癌的察觉和诊断比较数字早期胸部肿瘤Ⅹ射线测定法和 MRI 的有效性并且象二的联合一样估计这些形式的价值。有外科和病理的 57 个病人证明了胸损害的方法(恶意, n = 32;良性, n = 46 ) 经历了数字早期胸部肿瘤Ⅹ射线测定法和 MRI,脉搏序列包括了 T 1 WI, T 2 WI,弥漫的加权的成像(DWI ) ,和在外科前的动态提高对比的 MRI。这二种形式的结果,所有损害根据 BI-RADS 分类被分类进 5 个组,并且成像调查结果被相关到组织病理学说。每种形式的敏感以及二的联合是计算的。这 78 乳房损害的结果,敏感为数字早期胸部肿瘤Ⅹ射线测定法是 78.13%%(25/32 ) 并且 93.75%(30/32 ) 为 MRI (P >
0.05 ) 。特性是 73.91%%(34/46 ) 并且 89.13%(41/46 ) 因此(P <
0.05 ) ,他们俩出现了统计差别。当这二种形式在联合被使用,敏感和特性分别地是 98.63% 和 97.16% 。在有 MRI 的联合的结论数字早期胸部肿瘤Ⅹ射线测定法在乳癌,敏感和特性的诊断是有用的当时,被提高与单个形式的相比。 | Fang Ye Mengsu Zeng Fuhua Yan Wei Feng Meiling Zhou Renchen Li Wenfang Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 3 |
| 6 | The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis detection.Our aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC patients.Methods:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were enrolled.The diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively calculated.Survival difference was compared between patients receiving PET/CT or not after propensity score matching.Results:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was performed.Among 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,P<0.001)and accuracy(86.3%vs.73.2%,P<0.001)than conventional imaging in diagnosing regional lymph node metastasis,as well as higher sensitivity(87.8%vs.67.6%,P<0.001)and accuracy(93.5%vs.89.3%,P=0.023)in diagnosing distant metastasis.Overall,PET/CT improved the accuracy of preoperative staging from 60.1%to 71.8%(P<0.001),and modified clinical treatment strategy in 5.8%(17/291)of ICC patients,with unique roles in different tumor-node-metastasis(TNM)stages.High tumor-to-non-tumor ratio(TNR)predicted poor overall survival[hazard ratio(HR)=2.17;95%confidence interval(CI):1.49-3.15;P<0.001].Furthermore,patients performing PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score matching.Conclusions:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accurate tumor staging and optimal treatment allocation. | Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang Gao | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 3 |
| 7 | The effects of gold nanoparticles on the proliferation, differentiation, and mineralization function of MC3T3-E1 cells in vitro显示文摘This study has investigated the effects of gold nanoparticles (Au NPs) on the proliferation, differentiation, and mineralization of a murine preosteoblast cell line MC3T3-E1 in vitro. The results show that Au NPs with diameters of both 20 and 40 nm promoted the proliferation, differentiation, and mineralization of MC3T3-E1 cells in a time- and dose-dependent manner at the concentra-tions of 1.5×10-5, 3.0×10-5, and 1.5×10-4 μmol/L. The reverse transcriptase polymerase chain reaction (RT-PCR) indicates that the expressions of runt-related transcription factor 2 (Runx2), bone morphogenetic protein 2 (BMP-2), alkaline phosphatase (ALP), and osteocalcin (OCN) genes increased after the 20 and 40 nm Au NP treatments, and the expression levels were higher than those of the NaF group. The above results suggest that Au NPs have the potential to promote the osteogenic differentiation and miner- alization of MC3T3-E1 cells and the particle size plays a significant role in the process. Runx2, BMP-2, ALP, and OCN genes may interact with each other, further stimulating the osteogenic differentiation of MC3T3-E1 cells. | LIU DanDan ZHANG JinChao YI ChangQing YANG MengSu | 2010 | Chinese Science Bulletin2010，55，11： | 2 |
| 8 | Influence of AppLying Nitroglyceritt in Whole-Heart Free-Breathing 3 D Coronary MR Angiography 显示文摘 | JIN HANG ZENG MENGSU GE MEIYING | 2010 | A JR Am J Roentgeno12010，194，4： | 1 |
| 9 | Determination of trace amounts of beryllium( Ⅱ ) in drinking water and of beryllium vapor in air by graphite-furnace atomic absorption spectrophotometry using acetylacetone as a chelating agent 显示文摘 | PENG Haiwei KUO Mengsu | 2000 | Anal Sci2000，16，2： | 1 |
| 10 | Pattern recognition techniques for the emerging field of bioinfornlaties: A review 显示文摘 | LIEW A W C YAN HONG YANG MENGSU | 2005 | Pattern Recognition2005，38，11： | 1 |
| 11 | Effects of micro cystins on phosphorylase-a binding to phosphatase-2A:Kinetic analysis by surface plasmon resonance biosensor显示文摘 | Yang Mengsu Lam Paul K S Huang M | 1999 | Biochimica Biophysica Acta1999，1427，1： | 1 |
| 12 | The combined effect of hypertension and type-2 diabetes mellitus on aortic stiffness and endothelial dysfunction: an integrated study with high-resolution MRI显示文摘 | Yan Shan Jiang Lin Pengju Xu Mengsu Zeng Huandong Lin Hongmei Yan | 2013 | Magnetic Resonance Imaging2013，，： | 1 |
| 13 | Increased Liver Fat Content and Unfavorable Glucose Profiles in Subjects Without Diabetes 显示文摘 | Hua B I-Iongmei Y Mengsu Z | 2011 | Diabetes Technology & Therapeutics2011，13，： | 1 |
| 14 | Effects of small molecular inhibitors on the binding between HIV-1 reverse transcriptase and DNA as revealed by SPR biosensor显示文摘 | Lei Wu Qi Zhang Li Su Minghui Huang Jianlong Zhao Mengsu Yang | 2006 | Sensors & Actuators: B Chemical2006，，1： | 1 |
| 15 | Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway显示文摘 | Haifang Li Chichun Fong Yao Chen Guoping Cai Mengsu Yang | 2010 | Molecular and Cellular Endocrinology2010，，2： | 1 |
| 16 | Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells显示文摘 | Chi-Keung Wan Cheng Wang Hon-Yeung Cheung Mengsu Yang Wang-Fun Fong | 2005 | Cancer Letters2005，，1： | 1 |
| 17 | Evaluation of dual-phase helical dynam ic CT in the diagnosis of small HCC显示文摘 | YAN FUHUA ZENG MENGSU ZHOU KANGRONG | 1996 | Chin J Radiol1996，30，12： | 1 |
| 18 | Pancreatic Ad The different CT criteria for peripancreatic major arterial and venous invasion显示文摘 | LI Hui ZENG Mengsu ZHOU Kangrong | 2005 | J Comput Assist Tomogr2005，29，： | 1 |
| 19 | Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-β signaling pathway显示文摘 | Yue-Feng Shi Chi-Chun Fong Qi Zhang Pik-Yuen Cheung Chi-Hung Tzang Rudolf S.S. Wu Mengsu Yang | 2006 | FEBS Letters2006，，2： | 1 |
| 20 | Synthesis and antitumor activity of iodo-bridged binuclear platinum complex显示文摘Iodo-bridged binuclear platinum(II) com- plex[Pt( -NH2)I2]2(BPA) has been synthesized and characterized by elemental analysis, conductivity, differential thermal analysis, IR, UV and 1HNMR spectra techniques. The cytotoxicity of the complex was tested by MTT and SRB assays. The results show that complex BPA demonstrates better cyto-toxicity than that of the clinically established cisplatin against EJ, HCT-8, BGC-823, HL-60 and MCF-7 cell lines. The complex BPA at concentrations of 1.00 and 2.00 μmol/L induces G1 cell cycle arrest in HL-60 cells. The level of total platinum bound to DNA in HL-60 cells is significantly higher than that of cisplatin under the same experimental conditions. Acute tox-icity experimental results indiacte that LD50 of BPA is 815.3 mg/kg by intraperitoneal administration. BPA at dose of 12 mg/kg significantly inhibits the growth of nude mice implanted by human A2780 and HCT-116 carcinomas, and inhibition rate is similar to that of cisplatin at dose of 4 mg/kg by intraperitoneal admini-stration. BPA at dose of 20 mg/kg inhibits the growth of nude mice implanted by human A549 carcinomas, but there was no significant statistical difference. | ZHANG Jinchao GONG Yuqiu ZHENG Xiaoming YANG Mengsu CUI Jingrong | 2006 | Chinese Science Bulletin2006，51，8： | 1 |
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