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| 1 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 2 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 3 | Robust hydrogel sensors for unsupervised learning enabled sign-to-verbal translation显示文摘Highly stretchable and robust strain sensors are rapidly emerging as promising candidates for a diverse of wearable electronics.The main challenge for the practical application of wearable electronics is the energy consumption and device aging.Energy consumption mainly depends on the conductivity of the sensor,and it is a key factor in determining device aging.Here,we design a liq-uid metal(LM)-embedded hydrogel as a sensing material to overcome the bar-rier of energy consumption and device aging of wearable electronics.The sensing material simultaneously exhibits high conductivity(up to 22 S m�1),low elastic modulus(23 kPa),and ultrahigh stretchability(1500%)with excel-lent robustness(consistent performance against 12000 mechanical cycling).A motion monitoring system is composed of intrinsically soft LM-embedded hydrogel as sensing material,a microcontroller,signal-processing circuits,Bluetooth transceiver,and self-organizing map developed software for the visu-alization of multi-dimensional data.This system integrating multiple functions including signal conditioning,processing,and wireless transmission achieves monitor hand gesture as well as sign-to-verbal translation.This approach provides an ideal strategy for deaf-mute communicating with normal people and broadens the application of wearable electronics. | Hude Ma Haiyang Qin Xiao Xiao Na Liu Shaolei Wang Junye Li Sophia Shen Shuqi Dai Mengmeng Sun Peiyi Li Xiaofang Pan Mingjun Huang Baoyang Lu Jun Chen Lidong Wu | 2023 | InfoMat2023，5，7： | 1 |
| 4 | A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens显示文摘Currently,the cancer immunotherapy has made great progress while antitumor vaccine attracts substantial attention.Still,the selection of adjuvants as well as antigens are always the most crucial issues for better vaccination.In this study,we proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens.Briefly,endogenous calcium pyrophosphate nanogranules with possible immune potentiating effect are designed and engineered,both as delivery vehicles and adjuvants.Then,these nanocarriers are coated with lipids and B16-OVA tumor cell membranes,so the biomembrane proteins can serve as tumor-specific antigens.It was found that calcium pyrophosphate nanogranules themselves were compatible and possessed adjuvant effect,while membrane proteins including tumor associated antigen were transferred onto the nanocarriers.It was demonstrated that such a biomimetic nanovaccine could be well endocytosed by dendritic cells,promote their maturation and antigen-presentation,facilitate lymph retention,and trigger obvious immune response.It was confirmed that the biomimetic vaccine could induce strong T-cell response,exhibit excellent tumor therapy and prophylactic effects,and simultaneously possess nice biocompatibility.In general,the present investigation might provide insights for the further design and application of antitumor vaccines. | Minghui Li Mengmeng Qin Ge Song Hailiang Deng Dakuan Wang Xueqing Wang Wenbing Dai Bing He Hua Zhang Qiang Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 1 |
| 5 | The stomata frontline of plant interaction with the environment-perspectives from hormone regulation显示文摘植物发展了精致的机制从各种各样的环境条件察觉并且集成信号。在叶表面上, stomata 由一些警卫细胞形成了调停响应不能生活、关於生命的压力的煤气的交换,水蒸发以及功能。有气孔的闭合能被干旱,盐,病原体和另外的不利条件导致。这组成立刻的防卫回答阻止进一步的损坏到植物。Abscisic 酸(骆驼毛的织物) 是涉及压力回答的主要植物荷尔蒙。激活压力的骆驼毛的织物合成引起有气孔的闭合并且阻止开减少水损失和房间脱水。在表明小径的 ABA 的关键规章的受体建筑群和另外的重要部件被识别了。然而,我们在警卫房间的骆驼毛的织物信号 transduction 的知识是远非完全的。Jasmonates 是通常知道为对昆虫和 necrotrophic 病原体的植物防卫重要的一组植物激素。herbivory 和病原体侵略导致的甲基 jasmonate (MeJA ) 的增加的层次在作为骆驼毛的织物与 ROS 生产联系的有气孔的运动上显示出类似的效果。表明包含二重要植物激素的网络的警卫房间的调查重要、令人激动。蛋白质和代谢物部件的信息并且他们怎么在警卫房间交往,正在缺乏。这里,我们在在警卫房间表明网络的荷尔蒙上考察最近的进展并且网络怎么集成环境信号种生理的输出。 | Mengmeng ZHU Shaojun DAI Sixue CHEN | 2012 | Frontiers in Biology2012，7，2： | 1 |
| 6 | Aligning Fe_(2)O_(3)photo-sheets on TiO_(2)nanofibers with hydrophilic and aerophobic surface for boosting photoelectrochemical performance显示文摘Photoelectrochemical(PEC)nanomaterials are critical to producing clean oxygenation or value-added chemical production by utilizing sustainable solar energy,but are always limited by simultaneous integration of architectural engineering and electronic regulation in one structure.Directed by density functional theory(DFT)calculations and finite element analysis(FEA),the bioinspired ivy-like Fe_(2)O_(3)heterostructures with enriched oxygen defects on TiO_(2)nanofibers are designed for boosting PEC performances.Ivy-like Fe_(2)O_(3)photo-sheets remarkably enhanced the light harvesting by multiple light-mater interactions.The oxygen vacancies on Fe_(2)O_(3)photo-sheets could aid the photons catching and promote the reactivity at active sites.More importantly,demonstrated by a well-designed dynamic observation,the abundant tip-edges within ivy-like Fe_(2)O_(3)photo-sheets enabled the surface of heterostructure with hydrophilic and aerophobic properties.The functionalized surface allowed the rapid desorption of produced bubbles and thus ensured a high density of unoccupied active sites for electrolyte accessing.Featured by these attributes,the Fe_(2)O_(3)@TiO_(2)nanofibers delivered an excellent photocurrent of 40.8 mA/mg,high donor density(1.2×10^(18)cm^(−3)),and rapid oxygen production rate(1 mmol/(L∙h)).This work demonstrates a new strategy on nano-structural design for enhancing light-harvesting and making a hydrophilic/aerophobic surface on low-dimensional oxide nanomaterial,holding great potential on designing high-performance PEC devices for producing survival source gas,carbon-neutral fuel,and valuedchemicals. | Xiangyu Meng Qi Zhan Yanan Wu Mengmeng Zhu Ken Liu Na Wang Kuibo Yin Yueming Sun Shuai Dong Yunqian Dai | 2023 | Nano Research2023，16，3： | 0 |
| 7 | Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study显示文摘Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience. | Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai Mingyu Si Jiaqi Fu Xu Chen Mengmeng Jia Zhiwei Leng Dan Cui Winnie W.S.Mak Liming Dong Xiaoyou Su | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
| 8 | Boosting synergism of chemo- and immunotherapies via switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis by bisphosphonate coordination lipid nanogranules显示文摘Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted drugs.It is critical to inspire new potential to remodel the value of this classical therapeutic strategy.Here,we fabricate bisphosphonate coordination lipid nanogranules(BC-LNPs)and load paclitaxel(PTX)to boost the chemo-and immuno-therapeutic synergism of cytotoxic drugs.Alendronate in BC-LNPs@PTX,a bisphosphonate to block mevalonate metabolism,works as both the structure and drug constituent in nanogranules,where alendronate coordinated with calcium ions to form the particle core.The synergy of alendronate enhances the efficacy of paclitaxel,suppresses tumor metastasis,and alters the cytotoxic mechanism.Differing from the paclitaxel-induced apoptosis,the involvement of alendronate inhibits the mevalonate metabolism,changes the mitochondrial morphology,disturbs the redox homeostasis,and causes theaccumulation of mitochondrial ROS and lethal lipid peroxides(LPO).These factors finally trigger the ferroptosis of tumor cells,an immunogenic cell death mode,which remodels the suppressive tumor immune microenvironment and synergizes with immunotherapy.Therefore,by switching paclitaxel-induced apoptosis to mevalonate metabolism-triggered ferroptosis,BC-LNPs@PTX provides new insight into the development of cytotoxic drugs and highlights the potential of metabolism regulation in cancer therapy. | Ge Song Minghui Li Shumin Fan Mengmeng Qin Bin Shao Wenbing Dai Hua Zhang Xueqing Wang Bing He Qiang Zhang | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 9 | Simulating soil erodibility in southeastern China using a sequential Gaussian algorithm显示文摘Soil erodibility(K)is a key factor of soil erosion,and its appropriate quantification and interpolation are vitally important for soil and water conservation.The traditional point-represent-polygon approaches and common kriging method for the estimation of K,however,do not sufficiently represent the original data.The objectives of this study were to simulate the spatial distribution of K using a sequential Gaussian algorithm and analyze the uncertainty in evaluating the risk of soil erodibility in southeastern China.We determined 101 sampling points in the area and collected disturbed soil samples from the 0-20 cm layer at each point.Soil properties were determined,and K was calculated using five common models:the EPIC(Erosion/Productivity Impact Calculator),approximate nomograph,Torri,Shirazi,and Wang models.Among the chosen models,the EPIC model performed the best at estimating K(KEPIC),which ranged from 0.019 to 0.060 t ha h(ha MJ mm)^(-1),with a mean of 0.043 t ha h(ha MJ mm)^(-1).The KEPIC was moderately spatially variable and had a limited spatial structure,increasing from south to north in our study area,and all spatial simulations using the cooperative kriging(CK)interpolation and the sequential Gaussian simulation(SGS)with 10,25,50,100,200,and 500 realizations had acceptable accuracies.The CK interpolation narrowed the range,and the SGS maintained the original characteristics of the calculated data.The proportions of the risk area were 38.0% and 10.1%,when the risk probability for K was 60% and 80%,respectively,and high risk areas were mostly located in the north.The results provide scientific guidance for managing the risk of soil erodibility in southeastern China. | Xuchao ZHU Yin LIANG Zhiyuan TIAN Yi ZHANG Yugang ZHANG Jing DU Xin WANG Yu LI Lili QU Mengmeng DAI | 2021 | Pedosphere2021，31，5： | 0 |
| 10 | Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing显示文摘Apparently balanced chromosomal structural rearrangements are known to cause male infertility and account for approximately 1%of azoospermia or severe oligospermia.However,the underlying mechanisms of pathogenesis and etiologies are still largely unknown.Herein,we investigated apparently balanced interchromosomal structural rearrangements in six cases with azoospermia/severe oligospermia to comprehensively identify and delineate cryptic structural rearrangements and the related copy number variants.In addition,high read-depth genome sequencing(GS)(30-fold)was performed to investigate point mutations causative of male infertility.Mate-pair GS(4-fold)revealed additional structural rearrangements and/or copy number changes in 5 of 6 cases and detected a total of 48 rearrangements.Overall,the breakpoints caused truncations of 30 RefSeq genes,five of which were associated with spermatogenesis.Furthermore,the breakpoints disrupted 43 topological-associated domains.Direct disruptions or potential dysregulations of genes,which play potential roles in male germ cell development,apoptosis,and spermatogenesis,were found in all cases(n=6).In addition,high read-depth GS detected dual molecular findings in case MI6,involving a complex rearrangement and two point mutations in the gene DNAH1.Overall,our study provided the molecular characteristics of apparently balanced interchromosomal structural rearrangements in patients with male infertility.We demonstrated the complexity of chromosomal structural rearrangements,potential gene disruptions/dysregulation and single-gene mutations could be the contributing mechanisms underlie male infertility. | Matthew Hoi Kin Chau Ying Li Peng Dai Mengmeng Shi Xiaofan Zhu Jacqueline Pui Wah Chung Yvonne K Kwok Kwong Wai Choy Xiangdong Kong Zirui Dong | 2022 | Asian Journal of Andrology2022，24，3： | 0 |
| 11 | Genotype Screening of Recipient Resources with High Regeneration and Transformation Efficiency in Chrysanthemum显示文摘Genetic transformation is one of the key steps in the molecular breeding of chrysanthemum,which relies on an optimal regeneration and transformation system.However,the regeneration system of different chrysanthemum cultivars varies,and the regeneration time of most cultivars is long.To screen cultivars with highly efficient regeneration,leaves and shoot tip thin cell layers(tTCL)from eight chrysanthemum cultivars with different flower colors and flower types were cultured on Murashige and Skoog media(MS)supplemented with 1.0-5.0 mg L^(−1)6-benzylaminopurine(6-BA)and 0.1-1.0 mg L^(−1)α-naphthaleneacetic(NAA).The results showed that the most efficient regeneration media were MS+6-BA 1.0 mg L^(−1)+NAA 0.5 mg L^(−1)for leaf explants and MS+6-BA 5.0 mg L^(−1)+NAA 0.1 mg L^(−1)for tTCL explants.Subsequently,another 13 chrysanthemum cultivars were screened by using the media,and finally,three cultivars with high regeneration efficiency were obtained from 21 cultivars.Among these,C1 had the highest regeneration efficiency:the regeneration rate of leaf explants reached 80.0%after 42 days of culture,and the regeneration rate of tTCL explants reached 100%after 31 days of culture.Furthermore,we also established the transformation system for C1 as follows:preculturing for one day,infecting with Agrobacterium suspension(OD_(600)=0.6)for 10 min,and cultivating in the regeneration medium with 350 mg L^(−1)carbenicillin and 10 mg L^(−1)kanamycin,thus ultimately achieving a transformation rate of 4.0%.In this study,a new chrysanthemum cultivar with an efficient regeneration and transformation system was screened,which is beneficial to enrich the flower color of chrysanthemum transgenic plant recipients and to the functional research of flower color or type-related genes. | Yajun Li Yumeng Cui Bingjie Wang Yue Li Mengmeng Zhang Silan Dai He Huang | 2022 | Phyton-International Journal of Experimental Botany2022，91，4： | 0 |
| 12 | Biological function analysis of the phosphorylation sites for Arabidopsis CAP1显示文摘Cells need to respond successfully to ever-changing environmental conditions to maintain normal growth.This is achieved through various signal transduction cascades.Receptor-like kinases(RLKs)are involved in many aspects of the growth and development of plants.More than 600 RLKs have been identified and that are involved in various biological processes in | Yun Zhou Lu Zhang Zhangyun Wu Mengmeng Dai Luying Li Ling Bai Chunpeng Song | 2017 | Science Bulletin2017，62，11： | 0 |
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