|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 2 | DICER1 mutations in twelve Chinese patients with pleuropulmonary blastoma显示文摘Our aim is to examine the impact of DICER1 mutations on the pathogenesis of pleuropulmonary blastoma(PPB) by evaluating the mutation frequency and investigating the family history of Chinese patients with PPB. The family histories of 12 children with PPB recruited consecutively were surveyed. Blood samples from patients and their first-degree relatives were tested for DICER1 mutations. Whole-genome sequencing of blood samples and formalin-fixed and paraffin-embedded(FFPE) tumor tissue was performed in one family with twins. Twelve patients with PPB included six type II and six type III cases. Seven of the12 patients harbored DICER1 mutations, six of which were frameshift or nonsense mutations. Another case carried a germline DICER1 mutation affecting the splice site. FFPE sample had a nonsense mutation in TDG and missense mutations in DICER1.In addition, two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of PPB. Furthermore, one patient had a family history remarkable for thyroid diseases. Our results indicate that the germline mutation frequency in Chinese patients with PPB is similar to the ones reported for patients from USA, UK, and Japan. Moreover, our study strongly suggests that investigating the family history and detecting germline DICER1 mutations might be of benefit to increasing awareness and improving the accuracy of the differential diagnosis of PPB from non-malignant lung cysts. | Siyu Cai Xisi Wang Wen Zhao Libing Fu Xiaoli Ma Xiaoxia Peng | 2017 | Science China(Life Sciences)2017，60，7： | 5 |
| 3 | Research approaches to mass casualty incidents response:development from routine perspectives to complexity science显示文摘 | Shen Weifeng Jiang Libing Zhang Mao Ma Yuefeng Jiang Guanyu He Xiaojun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 4 | Defective ZnS nanoparticles anchored in situ on N-doped carbon as a superior oxygen reduction reaction catalyst显示文摘Defect engineering has been used to develop low-cost and effective catalysts to boost oxygen reduction reactions.However,the development of catalysts that use metal cation vacancies as the active sites for oxygen reduction reaction is lacking.In this study,ZnS nanoparticles on N-doped carbon serve as an oxygen reduction reaction catalyst.These catalysts were prepared via a one-step method at 900℃.Amazingly,the high-resolution transmission electron microscope image revealed obvious defects in the ZnS nanoparticles.These facilitated the catalyst synthesis,and the product displayed good electrocatalytic performance for the oxygen reduction reaction in an alkaline medium,including a lower onset potential,lower mid-wave potential,four electron transfer process,and better durability compared with 20 wt%Pt/C.More importantly,the density functional theory results indicated that using the Zn vacancies in the prepared catalyst as active sites required a lower reaction energy to produce OOH*from*OO toward oxygen reduction reaction.Therefore,the proposed catalyst with Zn vacancies can be used as a potential electrocatalyst and may be substitutes for Pt-based catalysts in fuel cells,given the novel catalyst’s resulting performance. | Libing Hu Zengxi Wei Feng Yu Huifang Yuan Mincong Liu Gang Wang Bangfiua Peng Bin Dai Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，12： | 3 |
| 5 | Living Bacteria-Mediated Aerobic Photoinduced Radical Polymerization for in Situ Bacterial Encapsulation and Differentiation显示文摘Conventional polymerizations mediated by living cells typically require synthetic transition-metal complexes or photoredox catalysts.Herein,we report an alternative photoinduced polymerization strategy for preparing functional polymer hydrogels through bacteria-initiated radical polymerization of acrylamides in ordinary culture media.Upon light irradiation under ambient conditions,polyacrylamides were obtained with molecular weights of over 150 kDa using various bacteria. | Huan Lu Yiming Huang Fengting Lv Libing Liu Yuguo Ma Shu Wang | 2021 | CCS Chemistry2021，3，7： | 2 |
| 6 | A Novel Driving and Control System for Direct-wheel- driven Electric Vehicle显示文摘 | Guilin Tao Zhiyum Ma Libing Zhou Langru Li | 2005 | IEEE Transactions on Magnetics (S0018-9464)2005，41，1： | 1 |
| 7 | A mobile edge computing-based applications execution framework for Internet of Vehicles显示文摘Mobile edge computing(MEC)is a promising technology for the Internet of Vehicles,especially in terms of application offloading and resource allocation.Most existing offloading schemes are sub-optimal,since these offloading strategies consider an application as a whole.In comparison,in this paper we propose an application-centric framework and build a finer-grained offloading scheme based on application partitioning.In our framework,each application is modelled as a directed acyclic graph,where each node represents a subtask and each edge represents the data flow dependency between a pair of subtasks.Both vehicles and MEC server within the communication range can be used as candidate offloading nodes.Then,the offloading involves assigning these computing nodes to subtasks.In addition,the proposed offloading scheme deal with the delay constraint of each subtask.The experimental evaluation show that,compared to existing non-partitioning offloading schemes,this proposed one effectively improves the performance of the application in terms of execution time and throughput. | Libing WU Rui ZHANG Qingan LI Chao MA Xiaochuan SHI | 2022 | Frontiers of Computer Science2022，16，5： | 1 |
| 8 | Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic显示文摘Background:Healthcare workers(HCWs)were the priority group for influenza vaccination,in China during the 2020/2021 and 2021/2022 influenza seasons.However,vaccination rates in HCWs have always been low.This study investigated influenza vaccination status among Chinese HCWs and analyzed the factors driving vaccination.Methods:We provided electronic questionnaires to HCWs from January 27,2022 to February 21,2022,using the WeChat platform'Breath Circles'.HCWs who received the link could also forward it to their colleagues.Binary logistic regression models were used to analyze vaccination-associated factors among HCWs.Results:Among the 1697 HCWs surveyed,vaccination coverage was 43.7%(741/1697)during the 2020/2021 influenza season,and 35.4%(600/1697)during the 2021/2022 influenza season,as of February 21,2022.Additionally,22.7%(385/1697)and 22.1%(358/1697)of HCWs reported that their workplaces implemented a free vaccination policy for all employees during the 2020/2021 and 2021/2022 influenza seasons.HCWs who were required to be vaccinated according to hospital regulations,and whose hospitals implemented the free influenza vaccine policy were more likely to be vaccinated(2020/2021 and 2021/2022;P<0.05).In addition,the economic level of the HCWs'province(2021/2022,P<0.05)and the HCWs’knowledge about vaccination and willingness to get vaccinated,such as active learning about vaccines(2020/2021,P<0.05),supportive attitude toward vaccination for all HCWs(2020/2021 and 2021/2022;P<0.05),also had an impact on vaccine coverage.Conclusions:A free influenza vaccination policy and workplace required vaccination are effective in improving influenza vaccination coverage among HCWs.Influenza vaccination coverage of Chinese HCWs remained low and showed a downward trend after the COVID-19 outbreak.Further effective measures,such as advocacy campaigns,free vaccine policies,and on-site vaccination could be implemented to improve influenza vaccination coverage. | Libing Ma Xuan Han Yuan Ma Yuan Yang Yunshao Xu Di Liu Weizhong Yang Luzhao Feng | 2022 | Infectious Diseases of Poverty2022，11，5： | 1 |
| 9 | A Novel Driving and Control System for Direct-Wheel-Drivan Electric Vehicle 显示文摘 | Guilin Tao Zhiyum Ma Libing Zhou Langru Li | 2005 | IEEE Transactions on Magnetics (S0018-9464)2005，41，1： | 1 |
| 10 | A novel driving and control system for direct-wheel-driven electric vehicle显示文摘 | Tao Guilin Ma Zhiyum Zhou Libing | 2005 | IEEE Transactions on Magnetics2005，41，1： | 1 |
| 11 | Recent developments in analytical applications of quantum dots显示文摘 | Hua Kuang Yuan Zhao Wei Ma Liguang Xu Libing Wang Chuanlai Xu | 2011 | Trends in Analytical Chemistry2011，，10： | 1 |
| 12 | A Novel Driving and Control System for Direct-Wheel-Driven Electric Vehicle 显示文摘 | Tao Guilin Ma Zhiyun Zhou Libing | 2005 | IEEE Transactions on Magnetics ( S0018 - 9464 )2005，41，1： | 1 |
| 13 | An aptamer-basedchromatographic strip assay for sensitive toxin semi-quantitativedetection显示文摘 | WANG Libing MA Wenwei CHEN Wei | 2011 | Biosensors and Bioelectronies2011，26，6： | 1 |
| 14 | A novel driving and control system for direct-wheel-driven electric vehicle显示文摘 | TAO Guilin MA Zhiyum ZHOU Libing | 2005 | IEEE Trans on Magnetics2005，41，1： | 1 |
| 15 | Characterization of uncommon portosystemic collateral circulations inpatients with hepatic cirrhosis显示文摘 | Qin Wu Lijun Shen Jindong Chu Xuemei Ma Bo Jin Fanping Meng Jinpin Chen Yanling Wang Libing Wu Jun Han Wenhui Zhang Wei Ma Huaming Wang Hanwei Li | 2015 | Oncology Letters2015，，1： | 1 |
| 16 | Monoclonal Antibody-Based Sandwich ELISA for the Detection of Staphylococcal Enterotoxin A显示文摘 | Kuang Hua Wang Wenbing Xu Liguang Ma Wei Liu Liqiang Wang Libing Xu Chuanlai | 2013 | International Journal of Environmental Research and Public Health2013，，4： | 1 |
| 17 | Crystal structure refinement of suolunite and its significance to the cement techniques显示文摘Based on the crystal structure refinement, the arrangement and characteristics of the double tetrahedra of Si-O backbone of suolunite have been precisely clarified. The double tetrahedra are isolated, and the orientations of the closely adjacent double tetrahedra are perpendicular to each other, which results in the poor cleavage and high hardness of suolunite. Com- | Zhesheng Ma Nicheng Shi Guodong Mou Libing Liao | 1999 | Chinese Science Bulletin1999，44，23： | 0 |
| 18 | MBD2 promotes Th2 differentiation in ovalbumin-induced CD4+T cells显示文摘Introduction:Allergen-specific CD4+T cells play a central role in autoimmune disorders,allergies and asthma,with Th2-type immunity being the typical functional response of CD4+T cells.This study aimed to investigate the role of MBD2 in regulating Th2 cell differentiation.Methods:Splenic mononuclear cells were extracted from C57BL/6 mice,and CD4+T cells were isolated using magnetic beads and confirmed through flow cytometry.Lentivirus was employed to construct MBD2-silenced CD4+T cells.In vitro experiments were performed to treat splenogenic mononuclear cells and CD4+T cells with Ovalbumin(OVA),and Th2 cell ratios and IL-4 levels were assessed using flow cytometry and ELISA.Results:The purity of the isolated CD4+T cells was 95.73%,confirming successful isolation of primary CD4+T cells.Compared to the control group,the Th2 cell ratio exhibited an increase in the Th2-induced group.Treatment with 5-Aza(concentrations,1-100μM)promoted Th2 cell differentiation and increased IL-4 levels.Notably,when combined with Th2 induction and 10μM 5-Aza treatment,silencing MBD2 further amplified Th2 cell ratios and elevated IL-4 levels in cell supernatants.Furthermore,OVA(concentration,200μg/mL)induced the differentiation of CD4+T cells into Th2 cells and increased IL-4 secretion.Interestingly,silencing MBD2 significantly increased the Th2 cell ratio and IL-4 levels in OVA-treated CD4+T cells.Conclusion:In summary,OVA promoted CD4+T cell differentiation into Th2 cells and enhanced IL-4 levels.MBD2 was identified as a mediator of Th2 cell differentiation in splenic-derived CD4+T cells,influenced by OVA or 5-Aza treatment. | QILU PAN YAN JIANG LINQIAO LI XIAOJING DU QIAN HAN FEIXIANG LING ROU LI SHUYUAN CHU LIN MAI JIANWEI HUANG LIBING MA | 2023 | BIOCELL2023，47，11： | 0 |
| 19 | Prokaryotic expression and purification of fusion protein HSP70-EGFP and its application in the study of dendritic cells internalization antigen显示文摘To study the endocytic activity of dendritic cells(DCs)by obtaining fusion protein HSP70-EGFP as exogenous antigen and loading it with DCs derived from human peripheral blood.Fusion protein HSP70-EGFP was prokaryotically expressed,isolated and purified.DCs were isolated and cultured from human peripheral blood.The DCs were divided into 3 groups in the endocytic experiment.There were 106 DCs in each group.Group 1 and 2 were respectively incubated for 30 min.with HSP70-EGFP and EGFP.Group 3 was incubated with HSP70 for 30 min,and then incubated for 30 min.with HSP70-EGFP.Subsequently,3 groups were placed in an incubator at 37℃for 0.5,1,2 and 24 h.Flow cytometry(FCM)was adopted to detect the amount of DCs with EGFP inside.IL-12 Eli-spot was adopted to detect the amount of DCs which secreted IL-12.There were 5 types in the experiment:LPS,inactive LPS,HSP70-EGFP,EGFP and no antigen.Fusion protein HSP70-EGFP was successfully obtained and its molecular weight was 97000.It accounted for 35.32%of the total protein.Under irradiation of an ultraviolet lamp,the protein solution sent out viridescent fluorescence.The result detected by FCM indicated that after incubation for 0.5 h at 37℃,the positive rate in group 1 was 63%,while the other 2 groups were negative.After incubation for 1,2 and 24 h at 37℃,the positive rates in the 3 groups were above 80%.The IL-12 Eli-spot examination shows that with HSP70-EGFP being loaded,the amount of DCs secreting IL-12 was 134.09±31.78/10^(5)cells,a little lower than that of DCs with LPS loaded(with the average point of 156.36±15.73).There was no significant difference between the 2 groups(P<0.01).By contrast,both of them were significantly higher than inactive LPS-(33.78±1.40)/10^(5)cells and EGFP-loaded(23.13±4.57)/105 cells DC groups in the amount of DCs secreting IL-12(P<0.01).The results suggest that receptor-mediated phagocytosis plays a main role in the preliminary stage of DCs internalizing HSP70-EGFP.With increasing incubation time,pinocytosis begins to dominate.HSP70-EGFP may promote DCs to secret cell factor IL-12. | Ping QU Yanfang SUI Libing LIU Jiahai MA Guangsheng CHEN Jiankang CHEN Fang’e LIU | 2008 | Frontiers of Medicine2008，2，1： | 0 |
| 20 | City-Specific Effects of Lifting Mobility Restrictions—China, February–March 2020显示文摘Summary What is already known about this topic?Government used mobility restrictions to help contain the first wave of coronavirus disease 2019(COVID-19)across cities in China.The restrictions were lifted during times of non-zero incidence in response to a return to work order that went into effect on February 10,2020.What is added by this report?The effect of lifting mobility restrictions on COVID-19 death rate and incidence varied by city,with smaller increases or even reductions in cities with low community connectivity and small floating volume,and larger increases in cities with high community connectivity and large floating volume.Effects on recovery rates were similar across cities.What are the implications for public health practice?City-specific mobility restriction lifting is likely to be beneficial.Two indexes,community connectivity and floating volume,can inform the design of city-specific mobility restriction lifting policies. | Shasha Han Libing Ma Ting Zhang Luzhao Feng Weizhong Yang Xiaoying Zheng | 2022 | China CDC weekly2022，4，31： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员