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| 1 | Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet显示文摘High-salt diet is well recognized as a risk factor for hypertension,and dietary intervention plays a critical role in the prevention of hypertension.The current study investigated the effects of selenium-enriched green tea(Se-GT)and ordinary green tea(GT)on prevention of hypertension of rats induced by high-salt diet,as well as their potential regulatory and mechanism.Our results showed that GT and Se-GT supplementations significantly prevented the increase of blood pressure(BP),activated the phosphoinosmde-3-kinase/protein kinase B(PI3K/Akt)signaling pathway,and regulated the gene expression related to BP,as well as improved the tissue damage like heart,liver,and kidneys.Besides,the key parameters associated with oxidative stress,inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments.Importantly,GT or Se-GT administration adjusted the diversity and composition of the intestinal flora.Moreover,GT and Se-GT supplementations increased the abundance of beneficial bacteria and reduced the abundance of harmful or conditional pathogenic bacteria.More specifically,GT intake specifically and significantly enriched the relative abundance of Paraprevotella and Bacteroides,whereas Se-GT was characterized by specific and significant enrichment for Allobaculum and Bifidobacterium.Our results proved that dietary supplement of GT and Se-GT remarkably improved the vascular functions and effectively prevented tissue damage by regulation of intestinal flora,and thus preventing hypertension induced by high-salt diet. | Meirong Wu Xiaobin Wu Jiangxiong Zhu Fanglan Li Xinlin Wei Yuanfeng Wang | 2022 | Food Science and Human Wellness2022，11，3： | 4 |
| 2 | Persistent Weakening Trend in the Spring Sensible Heat Source over the Tibetan Plateau and Its Impact on the Asian Summer Monsoon显示文摘 | Duan Anmin Li Fei Wang Meirong Wu Guoxiong | 2011 | Journal of Climate2011，，21： | 2 |
| 3 | Laboratory investigation into the oil diffusion from submarine pipeline under water flow显示文摘A physical model test has been conducted to study the oil diffusion from the submarine pipeline under water flow.The crude oil in the flume is spilled from a leakage point of the pipeline and diffused from the seabed to the surface. By the non-contact optical measuring technology, an image acquisition and data analysis system is designed to explore the spilled mechanism and characteristic. The oil trajectory, velocity and the rising time to the surface are obtained through this system. The influence of the water flow and the spilled discharge on the behavior of the spilled oil are analyzed from both qualitative and quantitative perspectives. The sensitivity study of the characteristic physical quantities to various factors are presented afterward. The spilled oil under water is mainly distributed in the form of the scattered particles with different sizes. The rising process of the oil can be divided into three stages: full, dispersion and aggregation period. The spilled discharge is the primary factor affecting the rising time of the oil particles. In the rising process of the oil particles, the vertical velocity of the oil is mainly affected by the spilled discharge, and the transverse velocity is more dependent on the water velocity. The deviation of the transverse oil velocity is much larger than that of the rising time and the vertical oil velocity. The study can provide a theoretical reference for the prediction system of oil spill emergency. | JIANG Meirong YU Jianxing LI Zhigang ZHONG Wenjun WU Zhaohui YU Yang | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 4 | Potential of amphiphilically modified low molecular weight chitosan as a novel carrier for hydrophobic anticancer drug: Synthesis, characterization, micellization and cytotoxicity evaluation显示文摘 | Yong Zhang Meirong Huo Jianping Zhou Di Yu Yiping Wu | 2009 | Carbohydrate Polymers2009，，2： | 1 |
| 5 | Using pectin to separate talc and molybdenite through the surface modification with Cu^(2+):Applications and mechanism显示文摘Organic depressants have low selectivity in separating molybdenite and talc because their metal sites lack activity for organics chemisorption.In this study,surface modification by copper sulfate was used to induce the differential adsorption of pectin onto molybdenite and talc surfaces for enhanced flotation separation.Contact-angle experiments,scanning electron microscopy,adsorption measurements,timeof-flight secondary-ion mass spectrometry,and X-ray photoelectron spectroscopy analyses were conducted to reveal the interaction mechanism.Results illustrated that molybdenite and talc could not be separated using pectin alone,while molybdenite was selectively depressed after surface modification by copper sulfate and this effect was strengthened under alkaline conditions.Metal sites(Mg,Si and Mo)of talc and molybdenite themselves were unable to react with pectin,whereas Cu+would deposit and further function as active site for pectin chemisorption after surface modification.However,the quantity of deposited Cu sites dropped on talc surface and increased on molybdenite surface with increased pH,and the Mo atoms of molybdenite crystal were activated to take part in pectin chemisorption.Therefore,more pectin was adhered on molybdenite surface,which imparted molybdenite stronger wettability.Herein,surface-modification through metal ions can enable the differential adsorption of organic depressants and enhance the flotation separation of minerals. | Changtao Wang Qilin Zhai Runqing Liu Meirong Wu Wei Sun Nianwen Jing Feifei Xie | 2023 | International Journal of Mining Science and Technology2023，33，3： | 1 |
| 6 | Fibers reinforced composite hydrogels with improved lubrication and load-bearing capacity显示文摘Hydrogels as one kind of soft materials with a typical three-dimensional(3D)hydrophilic network have been getting great attention in the field of biolubrication.However,traditional hydrogels commonly show poor tribology performance under high-load conditions because of their poor mechanical strength and toughness.Herein,pure chemical-crosslinking hydrogels mixed with different types of the micron-scale fibers can meet the requirements of strength and toughness for biolubrication materials,meanwhile the corresponding tribology performance improves significantly.In a typical case,three kinds of reinforcement matrix including needle-punched fibers,alginate fibers,and cottons are separately combined with Poly(n-vinyl pyrrolidone)-poly 2-hydroxyethyl methacrylate(PVP-PHEMA)hydrogels to prepare fibers reinforced composite hydrogels.The experimental results show that the mechanical properties of fibers reinforced composite hydrogels improve greatly comparable with pure PVP-PHEMA hydrogels.Among three kinds of fibers reinforced composite hydrogel,the as-prepared composite hydrogels reinforced with needle-punched fibers possess the best strength,modulus,and anti-tearing properties.Friction tests indicate that the fibers reinforced composite hydrogels demonstrate stable water-lubrication performance comparable with pure PVP-PHEMA hydrogels.Besides,the hydrogel-spunlace fiber samples show the best load-bearing and anti-wear capacities.The improved tribology performance of the composite hydrogels is highly related to mechanical property and the interaction between the fibers and hydrogel network.Finally,spunlace fibers reinforced hydrogel materials with high load-bearing and low friction properties are expected to be used as novel biomimetic lubrication materials. | Jiawei LI Luyao GAO Rongnian XU Shuanhong MA Zhengfeng MA Yanhua LIU Yang WU Libang FENG Meirong CAI Feng ZHOU | 2022 | Friction2022，10，1： | 1 |
| 7 | Conformational Transition and Liquid Crystalline State of Regenerated Silk Fibroin in Water 显示文摘 | LI Xingui WU Liya HUANG Meirong | 2008 | Biopolymers2008，89，6： | 1 |
| 8 | Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia显示文摘Aberrant self-renewal of leukemia initiation cells(LICs)drives aggressive acute myeloid leukemia(AML).Here,we report that UHRF1,an epigenetic regulator that recruits DNMT1 to methylate DNA,is highly expressed in AML and predicts poor prognosis.UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs.Mechanistically,UHRF1 directly interacts with Sin3A-associated protein 30(SAP30)through two critical amino acids,G572 and F573 in its SRA domain,to repress gene expression.Depletion of UHRF1 or SAP30 derepresses an important target gene,MXD4,which encodes a MYC antagonist,and leads to suppression of leukemogenesis.Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway.Lastly,we identified a UHRF1 inhibitor,UF146,and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model.Taken together,our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML. | Cheng-Long Hu Bing-Yi Chen Zijuan Li Tianbiao Yang Chun-Hui Xu Ruirui Yang Peng-Cheng Yu Jingyao Zhao Ting Liu Na Liu Bin Shan Qunling Zhang Junhong Song Ming-Yue Fei Li-Juan Zong Jia-Ying Zhang Ji-Chuan Wu Shu-Bei Chen Yong Wang Binhe Chang Dan Hou Ping Liu Yilun Jiang Xiya Li Xinchi Chen Chu-Han Deng Yi-Yi Ren Roujia Wang Jiacheng Jin Kai Xue Ying Zhang Meirong Du Jun Shi Ling-Yun Wu Chun-Kang Chang Shuhong Shen Zhu Chen Sai-Juan Chen Xiaolong Liu Xiao-Jian Sun Mingyue Zheng Lan Wang | 2022 | Cell Research2022，32，12： | 1 |
| 9 | CRESDA APPLICATION SYSTEM OF CBERS-1, RESULTS AND TYPICAL EXAMPLES OF APPLICATIONS显示文摘CRESDA Application System of CBERS-1 was established in 1999. During the operation of the system for more than two years, about 240 000 scenes of CBERS-1 Level 0 data have been archived and more than 13 000 scenes of Level 2 products have been ordered by end users from different application fields.In this paper, the typical examples of applications in crop yield estimation,calamity alleviation, resources survey and protection, environment monitoring and continuable development, and urban planning are mainly described. | WU Meirong | 2002 | 空间科学学报2002，22，z1： | 0 |
| 10 | Interfacial mechanism of hydrogel with controllable thickness for stable drag reduction显示文摘Surface wettability plays a significant role in reducing solid–liquid frictional resistance,especially the superhydrophilic/hydrophilic interface because of its excellent thermodynamic stability.In this work,poly(acrylic acid)-poly(acrylamide)(PAA–PAM)hydrogel coatings with different thicknesses were prepared in situ by polydopamine(PDA)-UV assisted surface catalytically initiated radical polymerization.Fluid drag reduction performance of hydrogel surface was measured using a rotational rheometer by the plate–plate mode.The experimental results showed that the average drag reduction of hydrogel surface could reach up to about 56%in Couette flow,which was mainly due to the interfacial polymerization phenomenon that enhanced the ability of hydration layer to delay the momentum dissipation between fluid layers and the diffusion behavior of surface.The proposed drag reduction mechanism of hydrogel surface was expected to shed new light on hydrogel–liquid interface interaction and provide a new way for the development of steady-state drag reduction methods. | Xiaotong WU Ying LIU Yunlei ZHANG Xingwei WANG Wufang YANG Lang JIANG Shuanhong MA Meirong CAI Feng ZHOU | 2024 | Friction2024，12，2： | 0 |
| 11 | β-decay study of neutron-rich nucleus ^(34)Al显示文摘The'island of inversion'has been known for over a quarter century,since Warburton et al.[1]proposed that nuclei with intruder ground states would constitute a 3×3 square with Z=10-12,N=20-22 in 1990.Uncovering the underlying inversion mechanism and exploring the scope of the island have attracted significant theoretical and experimental efforts in the following years.Now it is well known that the reduction of N=20 shell gap,which is likely caused by the | Rui Han XiangQing Li WeiGuang Jiang ZhiHuan Li Hui Hua ShuangQuan Zhang CenXi Yuan DongXing Jiang YanLin Ye Jing Li ZongHao Li FuRong Xu QiBo Chen Jie Meng JianSong Wang Chuan Xu YeLei Sun ChunGuang Wang HongYi Wu ChenYang Niu ChenGuang Li Chao He Wei Jiang PengJie Li HongLiang Zang Jun Feng SiDong Chen Qiang Liu XiaoChi Chen HuShan Xu ZhengGuo Hu YanYun Yang Peng Ma JunBing Ma ShiLun Jin Zhen Bai MeiRong Huang Yuan Jie Zhou WeiHu Ma Yong Li XiaoHong Zhou YuHu Zhang GuoQing Xiao WenLong Zhan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 0 |
| 12 | Immune microenvironment-reshaping Au@Bi_(2)Te_(3) nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy显示文摘Radiotherapy(RT)mediated tumor immunogenicity offers an opportunity for simultaneous RT and immunotherapy via immunogenic cell death(ICD),which releases damaged-associated molecular patterns and generates“eat me”signals for the innate immune system to modulate the immunogenicity.However,tumor hypoxia significantly reduces the therapeutic efficacy of RT and hampers its mediation of ICD induction.Herein,Au@Bi_(2)Te_(3)-polyethylene glycol(PEG)was rationally constructed as theranostic nanozymes for mild photothermal therapy,tumor hypoxia modulation,and RT adjuvant cancer immunotherapy.The tumor-specific production of oxygen could not only augment the effects of RT by enhanced reactive oxygen species(ROS)generation,but also reduce hypoxia-related cytokines and downregulate programmed cell death-ligand 1(PD-L1)to unleash immune-enhancing T cells.Moreover,Au@Bi_(2)Te_(3)-PEG could act as an immune-blocking inhibitor by efficient ICD induction with the combination of mild-photothermal therapy+RT to inhibit the tumor immune escape and improve antitumor immune response.Increased amounts of CD^(4+) and CD^(8+) Tcells and elevated levels of cytokines could be observed that eventually led to effective post-medication inhibition of primary and abscopal tumors.Spectral computed tomography/photoacoustic imaging allowed noninvasive and real-time tracking of nanoparticle(NP)accumulation and oxygenation status at tumor sites.Collectively,Au@Bi_(2)Te_(3)-PEG NPs could serve as effective theranostic nanoregulators with remarkable synergistic mildphotothermal/RT/immunotherapy effects that helped reshape the immune microenvironment and had remarkable molecular imaging properties. | Kai Zhu Zede Wu Qiuyu Li Meirong Hou Honglei Hu Shuting Zheng Li Qi Yikai Xu Chenggong Yan Bingxia Zhao | 2023 | Nano Research2023，16，1： | 0 |
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