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| 1 | Petrogenesis of Mesozoic granitoids and volcanic rocks in South China: A response to tectonic evolution显示文摘 | Xinmin Zhou Tao Sun Weizhou Shen Liangshu Shu Yaoling Niu | 2006 | Episodes2006，29，1： | 645 |
| 2 | Paleozoic structural and geodynamic evolution of eastern Tianshan (NW China): welding of the Tarim and Junggar plates显示文摘 | by Jacques Charve Liangshu Shu Sebastien Laurent-Charvett | 2007 | Episodes2007，30，3： | 109 |
| 3 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 4 | Two Faces of One Seed: Hormonal Regulation of Dormancy and Germination显示文摘种子植物演变维持刚成熟的种子的休眠直到萌芽的适当时间。种子休眠和萌芽是不同生理的过程,并且到萌芽的从休眠的转变是在植物的生命周期的关键发展的步,但是为农业生产也是重要的不仅。这些过程被多样的内长的荷尔蒙和环境暗示精确调整。尽管骆驼毛的织物(abscisic 酸) 和气体(赤霉素) 被知道是反对地调整种子休眠的主要植物激素,最近的调查结果表明那另外一个植物激素,植物生长素,为导致并且维持也是批评的播种休眠,可能因此充当种子休眠的一个关键保护者。在这评论,我们总结我们在调整种子休眠和萌芽包含植物激素的关键角色的复杂分子的网络的当前的理解,在里面它 AP2-domain-containing 抄写因素 playkey 角色。我们也在种子休眠和萌芽讨论多样的神经质的信号的相互作用(串音) ,集中于组成中央节点的 ABA/GA 平衡。 | Kai Shu Xiao-dong Liu Qi Xie Zu-hua He | 2016 | Molecular Plant2016，9，1： | 95 |
| 5 | Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer显示文摘Studies have shown cell-free microRNA(miRNA) circulating in the serum and plasma with specific expression in cancer,indicating the potential of using miRNAs as biomarkers for cancer diagnosis and therapy.This study was to investigate whether plasma miRNA-21(miR-21) can be used as a biomarker for the early detection of non-small cell lung cancer(NSCLC) and to explore its association with clinicopathologic features and sensitivity to platinum-based chemotherapy.We used real-time RT-PCR to investigate the expression of miR-21 in the plasma of 63 NSCLC patients and 30 healthy controls and correlated the findings with early diagnosis,pathologic parameters,and treatment.Thirty-five patients(stages IIIB and IV) were evaluable for chemotherapeutic responses:11 had partial response(PR);24 had stable and progressive disease(SD+PD).Plasma miR-21 was significantly higher in NSCLC patients than in age-and sex-matched controls(P<0.001).miR-21 was related to TNM stage(P<0.001),but not related to age,sex,smoking status,histological classification,lymph node status,and metastasis(all P>0.05).This marker yielded a receiver operating characteristic(ROC) curve area of 0.775(95% CI:0.681-0.868) with 76.2% sensitivity and 70.0% specificity.Importantly,miR-21 plasma levels in PR samples were several folds lower than that in SD plus PD samples(P=0.049),and were close to that in healthy controls(P=0.130).Plasma miR-21 can serve as a circulating tumor biomarker for the early diagnosis of NSCLC and is related to the sensitivity to platinum-base chemotherapy. | Juan Wei Wen Gao Cheng-Jun Zhu Yi-Qian Liu Zhu Mei Ting Cheng Yong-Qian Shu | 2011 | Chinese Journal of Cancer2011，30，6： | 63 |
| 6 | Palaeozoic tectonic evolution of the Tianshan belt,NW China显示文摘The Chinese Tianshan belt is a major part of the southern Central Asian Orogenic Belt,extending westward to Kyrgyzstan and Kazakhstan.Its Paleozoic tectonic evolution,crucial for understanding the amalgamation of Central Asia,comprises two stages of subduction-collision.The first collisional stage built the Eo-Tianshan Mountains,before a Visean unconformity,in which all structures are verging north.It implied a southward subduction of the Central Tianshan Ocean beneath the Tarim active margin,that induced the Ordovician-Early Devonian Central Tianshan arc,to the south of which the South Tianshan back-arc basin opened.During the Late Devonian,the closure of this ocean led to a collision between Central Tianshan arc and the Kazakhstan-Yili-North Tianshan Block,and subsequently closure of the South Tianhan back-arc basin,producing two suture zones,namely the Central Tianshan and South Tianshan suture zones where ophiolitic mélanges and HP metamorphic rocks were emplaced northward.The second stage included the Late Devonian-Carboniferous southward subduction of North Tianshan Ocean beneath the Eo-Tianshan active margin,underlined by the Yili-North Tianshan arc,leading to the collision between the Kazakhstan-Yili-NTS plate and an inferred Junggar Block at Late Carboniferous-Early Permian time.The North Tianshan Suture Zone underlines likely the last oceanic closure of Central Asia Orogenic Belt;all the oceanic domains were consumed before the Middle Permian.The amalgamated units were affected by a Permian major wrenching,dextral in the Tianshan.The correlation with the Kazakh and Kyrgyz Tianshan is clarified.The Kyrgyz South Tianshan is equivalent to the whole part of Chinese Tianshan(CTS and STS) located to the south of Narat Fault and Main Tianshan Shear Zone;the so-called Middle Tianshan thins out toward the east.The South Tianshan Suture of Kyrgyzstan correlates with the Central Tianshan Suture of Chinese Tianshan.The evolution of this southern domain remains similar from east(Gangou area) to west until the Talas-Ferghana Fault,which reflects the convergence history between the Kazakhstan and Tarim blocks. | Jacques CHARVET SHU LiangShu Sebastien LAURENT-CHARVET WANG Bo Michel FAURE Dominique CLUZEL CHEN Yan Koen De JONG | 2011 | Science China Earth Sciences2011，54，2： | 57 |
| 7 | Late Mesozoic basin and range tectonics and related magmatism in Southeast China显示文摘在迟了的中生代中间的 JurassicLate 白垩纪期间,盆和范围 tectonics 和 extensional 的联系 magmatism 代表构造设定在由于和平的板 subduction 的东南的中国是普遍的。盆 tectonics 由 post-orogenic 组成(类型我) 并且 intra 大陆人 extensional 盆(类型 II ) 。类型我盆在山麓和 intraland 发展了在期间对早侏罗记,纹理粗糙的陆上的碎屑状的沉积在被扔晚三叠纪。在 intra 大陆人期间形成的类型 II 盆外壳的变瘦并且被 grabens 和 half-grabens 的发展描绘。Graben 盆主要在中间的侏罗记期间被产生并且与 bimodal 火山作用被联系。在 half-grabens 的沉积与 rhyolitic 凝灰岩和熔岩被设置并且近来是在有优势的年龄的早白垩纪 CretaceousPaleogene 红床。范围由 granitoids 和 bimodal 组成暴烈的岩石, A 类型花岗石和屋顶类型变形核心建筑群。作者分析了 lithological, geochemical 和迟了的中生代火的岩石集合的 geochronological 特征并且在形成华南的盆和范围 tectonics 上建议了一些地球动力学的限制。类似的比较和在东方、西方的岸之间的盆和范围 tectonics 的差别和平被做,并且东南中国块的地球动力学的进化模型在迟了的中生代期间被讨论。学习结果建议华南在合拢的中生代前上开发了的在内的盆和范围岩层系上带子从自从迟了的中生代,西方的和平的板的 subduction 主要抑制的多相的构造进化被导出,在一个背弧 extensional 背景导致各种各样的 magmatism 的形成。它的 geodynamic 机制能在东方岸与盆和范围 tectonics 的作比较和平。在两岸之间的盆和范围 tectonics 的差别和平例如披风羽毛形成, extensional 和火的岩石集合和盆和范围 tectonics 的年龄可伸缩,主要被 Yellowstone 披风羽毛在太平洋的东方岸引起。 | Dezi Wang Liangshu Shu | 2012 | Geoscience Frontiers2012，3，2： | 60 |
| 8 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 9 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 10 | Lithology, kinematics and geochronology related to Late Mesozoic basin-mountain evolution in the Nanxiong-Zhuguang area, South China显示文摘The Nanxiong red-bed basin and its adjacent Zhuguang granite form a distinctive basin-mountain landform in the Nanling region, South China. Research results suggest that the Zhuguang granite is a polyphase composite pluton developed on the metamorphic basement of the paleo-Tethys-paleo-Asian tectonic regime and possesses geometrical and kinematic features of hot-doming extensional tectonics at the middle-upper crustal level, which is considered as a magmatic complex that resulted from the collision-orogeny during the Indosinian Period, the subduction-consuming during the Early Yanshanian Period and the intra-continental basaltic underplating and deep-seated geodynamics during the Late Yanshanian Period. The Nanxiong basin is a Late Cretaceous-Paleogene asymmetric faulted basin that is characterized by a fault boundary on the northern side and an uncomformable boundary on the southern side, its deposit center was migrated gradually from south to north. Structural kinematic results on the ba-sin-mountain coupled zone demonstrate that the ductile and the brittle rheological layers show a quite coincident sense of shear, implying that it is a continuous process from the ductile exten-sional deformation followed by locally sinistral strike-slip shear at a middle-crustal level to the brittle tensional deformation at a upper-crustal level during formation of granitic doming exten-sional tectonics. The Zhuguang granite and the Nanxiong faulted basin constructed a semi-graben tectonic system. Lithological and geochemical results suggest that the Late Triassic to Jurassic granitic bodies in the Zhuguang have some similar features: high SiO2, Al2O3, K2O contents, alkalinity index > 2.8, ANKC value > 1.1, LREE-enriched pattern with high REE con-tents, marked negative Eu anomalies, enrichment in Rb and Th, depletion in Ba and Nb, showing a K-rich and Al-rich calc-alkaline affinity, which suggest a continuous magmatic evolution from Late Triassic to Jurassic. Formation of Nanxiong basin and evolution of basin-mountain system were controlled both by the Zhuguang granitic-doming and the regional extensional tectonics. Development of the olivine basalt in the basin suggests that tension action was very strong dur-ing lava eruption. The magma-type zircon grains of basalt from the Nanxiong basin yielded the SHRIMP age of 96?Ma, providing reliable geochronological constraint on the tectono-thermal event and basin-mountain evolution in the Nanling region, South China. | SHU Liangshu1, DENG Ping1,2, WANG Bin1, TAN Zhengzhong2, YU Xinqi1 & SUN Yan1 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Research Institute No.290, CNNC, Shaoguan 512026, China | 2004 | Science China Earth Sciences2004，47，8： | 41 |
| 11 | SHRIMP zircon U-Pb age, fitho- and biostratigraphic analyses of the Huaiyu Domain in South China,— Evidence for a Neoproterozoic orogen, not Late Paleozoic-Early Mesozoic collision显示文摘 | Liangshu Shu Michel Faure Shaoyong Jiang Qun Yang Yujing Wang | 2006 | Episodes2006，29，4： | 47 |
| 12 | Performance value of high risk factors in colorectal cancer screening in China显示文摘AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in China.METHODS:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire investigation.Patients with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo colonoscopy.RESULTS:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced neoplasia.The iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.Except for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.CONCLUSION:The iFOBT may be the best marker for screening for advanced neoplasias and adenomas.Some unique high risk factors may play an important role in CRC screening in China. | Wen Meng Shan-Rong Cai Lun Zhou Qi Dong Shu Zheng Su-Zhan Zhang | 2009 | World Journal of Gastroenterology2009，15，48： | 41 |
| 13 | Prevalence of Atrial Fibrillation in China and Its Risk Factors显示文摘Objective To study the prevalence of atrial fibrillation(AF)and the relation with its risk factors in China.Methods A total of 19 363 participants(8635 males and 10 728 females) aged ≥35 years in geographically dispersed urban and rural regions of China were included in this cross-sectional survey.All participants received questionnaire,physical and blood examination.Echocardiography were performed for AF patients found in the survey.Results Of the 19 363 participants,199 were diagnosed with AF.The estimated age-standardized prevalence of AF was 0.78% in men and 0.76% in women.The prevalence of AF in participants aged <60 years was 0.41% in men and 0.43% in women,and was 1.83% in both men and women aged ≥60 years.About 19.0% of males and 30.9% of females with AF were diagnosed with valve disease.Age-and sex-adjusted multivariable logistic regression analysis revealed that myocardial infarction,left ventricular hypertrophy(LVH),obesity,and alcohol consumption were associated with a increased risk of AF(P<0.05).Conclusion The age standardized prevalence of AF is 0.77% in the participants enrolled in the present study.The number of AF cases aged ≥35 years is 5.26 million according to 2010 Chinese Census.Most risk factors for AF,identified mainly in Western countries,are also detected in China. | LI Ying WU Yang Feng CHEN Ke Ping LI Xian ZHANG Xing XIE Gao Qiang WANG Fang Zheng ZHANG Shu | 2013 | Biomedical and Environmental Sciences2013，26，9： | 48 |
| 14 | Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus显示文摘Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China.As of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in China.Of these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 years.Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | Zhi-Min Chen Jun-Fen Fu Qiang Shu Ying-Hu Chen Chun-Zhen Hua Fu-Bang Li Ru Lin Lan-Fang Tang Tian-Lin Wang Wei Wang Ying-Shuo Wang Wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-Ming Yuan Chen-Mei Zhang Yuan-Yuan Zhang | 2020 | World Journal of Pediatrics2020，16，3： | 45 |
| 15 | 胃癌预防亚太地区共识指南显示文摘背景与目的:胃癌是亚太地区的主要健康负担之一,但对其预防策略尚缺乏共识。本共识会议旨在评价预防胃癌的策略。方法:多学科专家组应用德尔菲(Delphi)法制订共识条文,提呈相关数据,对证据等级、推荐强度以及共识水平予以分级。结果:幽门螺杆菌(H.pylori)感染是非贲门胃腺癌必要但非充分的致病因子。盐的高摄入与胃癌强烈相关。新鲜果蔬对胃癌具有预防作用,但维生素和其他饮食补充并不能预防胃癌。H.pylori感染中的宿主-细菌相互作用导致不同类型的胃炎和胃酸分泌,从而决定疾病结局。胃癌阳性家族史是一个重要的危险因素。低血清胃蛋白酶原反映胃萎缩程度,可作为检出胃癌高危人群的标志物。H.pylori筛查和治疗被推荐作为减少高危人群胃癌危险性的一种策略,该策略在萎缩性胃炎发生前实施最为有效,但并不排除对胃癌高危人群的内镜监测。对胃癌低危人群不推荐行H.pylori筛查。H.pylori感染的一线治疗应遵循国家治疗指南。结论:高危人群中H.pylori筛查和根除策略可能会减少胃癌的发生率,本共识根据现有证据予以推荐。 | Kwong Ming Fock Nick Talley Paul Moayyedi Richard Hunt Takeshi Azuma Kentaro Sugano Shu Dong Xiao Shiu Kum Lam Khean Lee Goh Tsutomu Chiba Naomi Uemura Jae G Kim Nayoung Kim Tiing Leong Ang Varocha Mahachai Hazel Mitchell Abdul Aziz Rani Jyh Ming Liou Ratha-korn Vilaichone Jose Sollanor 钱本余 | 2008 | 胃肠病学2008，13，4： | 37 |
| 16 | Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues显示文摘MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the immuno- inflammatory response; however, the function of miRNAs in periodontal inflammation has not been investigated. The objective of this study was to explore the properties of miRNAs in periodontal inflammation by comparing miRNA profiles of inflamed and healthy gingival tissues. Gingival tissues were obtained from 10 periodontitis patients and 10 healthy subjects. After RNA extraction, miRNA profiles were analyzed by microarray, and expression levels of selected miRNAs were confirmed by real-time quantitative reverse transcription polymerase chain reaction (RT-PCR). Analyses using two computational methods, Targetscan and MicroRNA.org, were combined to identify common targets of these miRNAs. Finally, the individual miRNA expression levels of three toll-like receptor (TLR)-related miRNAs from inflamed and healthy gingival tissues were evaluated by RT-PCR. Ninety-one miRNAs were found to be upregulated and thirty-four downregulated over two-fold in inflamed gingival tissue compared with those in healthy gingival tissue. Twelve selected inflammatory-related miRNAs, hsa-miR-126*, hsa-miR-20a, hsa-miR-142-3p, hsa-miR-19a, hsa-let-7f, hsa-miR-203, hsa-miR-17, hsa-miR-223, hsa-miR-146b, hsa-miR-146a, hsa-miR-155, and hsa-miR-205 showed comparable expression levels by microarray and real-time quantitative RT-PCR analyses. In addition, the putative inflammation targets of these miRNAs were predicted, and three that were tested (hsa-miRNA-146a, hsa-miRNA-146b, and hsa-miRNA-155), showed significant differences between inflamed and healthy gingiva. This remarkable difference in miRNA profiles between periodontal diseased and healthy gingiva implicates a probable close relationship between miRNAs and periodontal inflammation. The data also suggest that the regulation of TLRs in periodontal inflammation may involve miRNA pathways. | Yu-feng Xie Rong Shu Shao-yun Jiang Da-li Liu Xiu-li Zhang | 2011 | International Journal of Oral Science2011，3，3： | 36 |
| 17 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 18 | The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial显示文摘 | Wei Hua Run-Lin Gao Bu-Chang Zhao Jing Wang Xu-Hua Chen Chi Cai Shu Zhang | 2015 | Chinese Medical Journal2015，，19： | 35 |
| 19 | 3D bioactive composite scaffolds for bone tissue engineering显示文摘Bone is the second most commonly transplanted tissue worldwide,with over four million operations using bone grafts or bone substitute materials annually to treat bone defects.However,significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma,cancer,infection and arthritis.Developing bioactive three-dimensional(3D)scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering(BTE).A variety of materials and manufacturing methods including 3D printing have been used to create novel alternatives to traditional bone grafts.However,individual groups of materials including polymers,ceramics and hydrogels have been unable to fully replicate the properties of bone when used alone.Favourable material properties can be combined and bioactivity improved when groups of materials are used together in composite 3D scaffolds.This review will therefore consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers,hydrogels,metals,ceramics and bio-glasses in BTE.Scaffold fabrication methodology,mechanical performance,biocompatibility,bioactivity,and potential clinical translations will be discussed. | Gareth Turnbull Jon Clarke Frederic Picard Philip Riches Luanluan Jia Fengxuan Han Bin Li Wenmiao Shu | 2018 | Bioactive Materials2018，3，3： | 40 |
| 20 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
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