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| 1 | Regulation of innate immune responses by rabies virus显示文摘Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public safety.It is well known that innate immunity is the critical first line of host defense against viral infection.It monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any drugs.Therefore,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its infection.Here,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies. | Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 2 |
| 2 | A Secure Three-Factor Authenticated Key Agreement Scheme for Multi-Server Environment显示文摘Multi-server authenticated key agreement schemes have attracted great attention to both academia and industry in recent years.However,traditional authenticated key agreement schemes in the single-server environment are not suitable for the multi-server environment because the user has to register on each server when he/she wishes to log in various servers for different service.Moreover,it is unreasonable to consider all servers are trusted since the server in a multi-server environment may be a semi-trusted party.In order to overcome these difficulties,we designed a secure three-factor multi-server authenticated key agreement protocol based on elliptic curve cryptography,which needs the user to register only once at the registration center in order to access all semi-trusted servers.The proposed scheme can not only against various known attacks but also provides high computational efficiency.Besides,we have proved our scheme fulfills mutual authentication by using the authentication test method. | Meichen Xia Shiliang Li Liu Liu | 2020 | Computers, Materials & Continua2020，，9： | 1 |
| 3 | Expression, purification and antibody preparation using different constructs of PCV2 capsid protein显示文摘 | Fuwang Chen Xin Yang Daxing Pang Zhiyuan Peng Meichen Dong Xiaoyun Liu Hongsheng Ouyang Linzhu Ren | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 4 | Constructing a World in George Orwell’s Burmese Days显示文摘本文旨在对乔治·奥威尔的小说《缅甸岁月》进行后殖民主义解读。本文认为,《缅甸岁月》是一部由人物主导的小说,书中作者并未对英国殖民历史以及故事发生当时的社会环境进行阐述。这样安排的目的是尽量减少读者的偏见,使其在不了解历史背景的情况下,仅仅依据小说中人物的话语及行为形成自己对殖民体系以及对两种文化优劣势的看法。结局中缅甸地方官U Po Kyin最终棋高一步,智胜那些自认为更加优越的英国人,也印证了殖民体系自身的缺陷。 | Meichen LIU | 2016 | Comparative Literature:East & West2016，，2： | 0 |
| 5 | Development and Validation of UHPLC-MS/MS Method for Quantifying of Agarotriose:An Application for Pharmacokinetic,Tissue Distribution,and Excretion Studies in Rats显示文摘A sensitive,rapid,and robust ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was established for the first time to quantify agarotriose(A3)in rat plasma,tissues,urine,and feces.A3 and stachyose(internal standard)were separated by a BEH amide column at 65℃under the mobile phase of 10 mmol L^(-1)ammonium ace-tate-acetonitrile(42:58,v/v)with 350µLmin-1.The acquisition of transitions was carried out in multiple reaction monitoring(MRM)pattern operating with positive ionization at m/z 509.16>329.15 for A3 and m/z 689.15>527.11 for stachyose.The linearity ranges of A3 were 10 to 5000nmolL^(-1)for plasma,20 to 10000nmolL^(-1)for tissues,and 40 to 20000nmolL^(-1)for urine and feces.The accuracy and precision ranged from 90.9%to 111.6%and 0.7%to 10.1%,respectively.The stability was between 86.1%and 102.5%.The extraction recovery was consistent and reproducible.The matrix effect ranged from 1.5%to 11.4%.The pharmacokinetic,tissue dis-tribution,and excretion studies were successfully conducted with the validated method.Results showed that A3 could be absorbed by rats,and the absolute bioavailability was 6.7%.Furthermore,it was rapidly distributed in rat tissues and mainly eliminated via feces excretion(67.0%)after oral administration.For intravenous bolus,85.5%was recovered,and renal excretion was the primary path-way(77.6%)for cumulative recovery. | YUE Jiali CHENG Wei WEI Shutong LIU Guilin ZHOU Meichen LV Zhihua YU Mingming | 2023 | Journal of Ocean University of China2023，22，6： | 0 |
| 6 | Regulation of hydrogen evolution performance of titanium oxide-carbon composites at high current density with a Ti-O hybrid orbital显示文摘Rational design and controllable synthesis of practical electrodes with high sta bility and activity at high current density for a hydrogen evolution reaction(HER)are critical for renewable and sustainable energy conversion.However,high-performance TiO_(2)-based electrocatalysts for HER are quite limited,and the cat alytic active centers still remain elusive.Herein,a simple strategy is demonstrated for the synthesis of TiO_(2)-carbon composite(TiO_(2)/C)with high HER performance and stability.The remarkable HER performance of TiO_(2)/C can be ascribed to the doping of carbon atoms,which leads to stronger hybridization of Ti 3d and O 2p orbitals,thus substantially improving the electrocatalytic efficiency.This study elucidates that the hydrogen evolution activity of oxide electrocatalysts can be largely improved by regulating their electronic structures by doping carbon atoms and also provides an effective strategy for designing heterostructured electro catalysts with high catalytic activity and stability at high current density for HER. | Meichen Liu Zhiping Lei Qingping Ke Peixin Cui Jiancheng Wang Jingchong Yan Zhanku Li Hengfu Shui Shibiao Ren Zhicai Wang Ying Kong Shigang Kang | 2022 | Carbon Energy2022，4，3： | 0 |
| 7 | Dose-Response Meta-Analysis on Risk of Diabetes in Relation to Red and Processed Meat Consumption—Asian Populations,2006−2021显示文摘Summary What is already known about this topic?Red and processed meat consumption has been positively related to an increased risk of diabetes in Western populations.However,the results remain inconclusive within Asian populations.What is added by this report?This dose-response meta-analysis of prospective cohort studies conducted in East Asian populations reveals a positive relation between the consumption of processed meat and increased risk of diabetes.Furthermore,a Ushaped association was identified between the consumption of unprocessed red meat and the risk of diabetes.What are the implications for public health practice?This research presents substantive evidence advocating for the reduction of processed and unprocessed red meat consumption as a viable strategy for mitigating the risk of diabetes in East Asian populations. | Hancheng Yu Jijuan Zhang Jinchi Xie Xianli Li Youjing Wang Yijia Yang Fengshuang Zhou Meichen Liu Zhe Zhang Zhilei Shan Gang Liu An Pan | 2023 | China CDC weekly2023，5，45： | 0 |
| 8 | BnbHLH92a negatively regulates anthocyanin and proanthocyanidin biosynthesis in Brassica napus显示文摘Yellow seed trait is a desirable characteristic with potential for increasing seed quality and commercial value in rapeseed,and anthocyanin and proanthocyanidins(PAs)are major seed-coat pigments.Few transcription factors involved in the regulation of anthocyanin and PAs biosynthesis have been characterized in rapeseed.In this study,we identified a transcription factor gene BnbHLH92a(BnaA06T0441000ZS)in rapeseed.Overexpressing BnbHLH92a both in Arabidopsis and in rapeseed reduced levels of anthocyanin and PAs.Correspondingly,the expression profiles of anthocyanin and PA biosynthesis genes(TT3,BAN,TT8,TT18,and TTG1)were shown by quantitative real-time PCR to be inhibited in BnbHLH92a-overexpressing Arabidopsis seeds,indicating that BnbHLH92a represses the anthocyanin and PA biosynthesis pathway in Arabidopsis.BnbHLH92a physically interacts with the BnTTG1 protein and represses the biosynthesis of anthocyanins and PAs in rapeseed.BnbHLH92a also binds directly to the BnTT18 promoter and represses its expression.These results suggest that BnbHLH92a is a novel upstream regulator of flavonoid biosynthesis in B.napus. | Ran Hu Meichen Zhu Si Chen Chengxiang Li Qianwei Zhang Lei Gao Xueqin Liu Shulin Shen Fuyou Fu Xinfu Xu Ying Liang Liezhao Liu Kun Lu Hao Yu Jiana Li Cunmin Qu | 2023 | The Crop Journal2023，11，2： | 0 |
| 9 | Magnesium Demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress显示文摘Cantharidin(CTD)is a bioactive ingredient isolated from Cantharis vesicatoria(blister beetles),which has potential therapeutic value as an anticancer agent.Magnesium Demethylcantharidate(MDC)is a recently developed derivative of Cantharidin(CTD),and previous studies have illustrated its excellent anticancer activity on HCC cells.However,the effect and mechanism of MDC remains unclear and need to be further studied.In particular,whether MDC can cause ER stress in HCC is still unknown.In this study,we demonstrated that endoplasmic reticulum stress(ERS)-related proteins were changed in SMMC-7721 and Bel-7402 cells after being exposed to MDC.Moreover,we found that MDC could significantly inhibit the growth of xenograft tumor in nude mice.In summary,we confirmed that MDC could induce ERS in HCC cells and thus induce apoptosis. | XINTING ZHU MENG YE KELAN FANG FANG LIU JING HUI MEICHEN LIU XIAOFEI LI RONG YAN YUN LIU | 2022 | BIOCELL2022，46，12： | 0 |
| 10 | Survey on person re-identification based on deep learning显示文摘Person re-identification(Re-ID)is a fundamental subject in the field of the computer vision technologies.The traditional methods of person Re-ID have difficulty in solving the problems of person illumination,occlusion and attitude change under complex background.Meanwhile,the introduction of deep learning opens a new way of person Re-ID research and becomes a hot spot in this field.This study reviews the traditional methods of person Re-ID,then the authors focus on the related papers about different person Re-ID frameworks on the basis of deep learning,and discusses their advantages and disadvantages.Finally,they propose the direction of further research,especially the prospect of person Re-ID methods based on deep learning. | Kejun Wang Haolin Wang Meichen Liu Xianglei Xing Tian Han | 2018 | CAAI Transactions on Intelligence Technology2018，3，4： | 0 |
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