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| 1 | One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy显示文摘We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation(808nm,2 W/cm^2,5 min), the PLC-b-PEO@Au NPs(1mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin(DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy(CT) or photothermal therapy(PT), demonstrating a synergistic effect. | Siqi Yang Linzhu Zhou Yue Su Rong Zhang Chang-Ming Dong | 2019 | Chinese Chemical Letters2019，30，1： | 6 |
| 2 | Control of Aggregate Size of Polyethyleneimine-Coated Magnetic Nanoparticles for Magnetofection显示文摘Using magnetic nanoparticles to enhance gene transfection,a recently developed technique termed magnetofection,has been shown to be a powerful technology in gene delivery.The most widely used magnetic nanoparticles in this area are those coated with polyethyleneimine,which is a well known non-viral transfection agent.In this article,we report methods to control the aggregate size of polyethyleneimine-coated magnetite particles.These particles were then used to enhance transfection of green fluorescent protein(GFP)into NIH 3T3 cells in vitro.We find that the aggregate size of the particles has a great effect on their performance in magnetofection,with less aggregated magnetic particles being more effective in enhancing the gene transfection. | Xiaoliang Wang Linzhu Zhou Yongjie Ma Xu Li Hongchen Gu | 2009 | Nano Research2009，2，5： | 4 |
| 3 | Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs显示文摘The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels.However,using angiogenesis inhibitors alone does not meet the cancer treatment needs.Herein,we used the amphiphilic drug-drug conjugate(ADDC)strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together.With one-step esterification of hydrophilic floxuridine(FUDR)and hydrophobic pseudolaric acid B(PAB),the conjugate was synthesized.The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water.From further in vitro and in vivo experiments,this FUDR-PAB conjugate does not only have a high antitumor effect,but also shows efficient antianiogenesis property.These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together. | Mo Sun Qiuhui Qian Leilei Shi Li Xu Qunfang Liu Linzhu Zhou Xinyuan Zhu Jian-Min Yue Deyue Yan | 2020 | Science China Chemistry2020，63，1： | 3 |
| 4 | The Expression of MMP-3 and TIMP-1 During Orthodontic Periodontium Remodeling in Rats显示文摘目的 :观察大鼠正畸牙周组织改建过程中基质金属蛋白酶 - 3(MMP - 3)和金属蛋白酶组织抑制因子 - 1(TIMP - 1)表达的变化 ,探讨MMP - 3及TIMP - 1与正畸牙齿移动的关系。方法 :在SD成年大鼠上颌右侧第一磨牙与上颌切牙之间安置正畸装置 ,建立大鼠磨牙移动实验模型。于牙齿移动 1、3、5、7、14d后取材分别进行免疫组化染色、图像分析。结果 :牙齿移动 1d后 ,牙周组织细胞MMP - 3表达增强 ,5d后MMP - 3表达达到高峰 ,此时破骨细胞胞浆亦呈强阳性表达。以后MMP - 3表达有所下降 ,但仍高于对照组。而TIMP - 1于牙齿移动 3d后表达开始增强 ,7d后显著表达。结论 :MMP - 3及TIMP - 1参与了正畸牙周组织改建过程 ,MMP - 3在破骨细胞性骨吸收中起着重要作用。 | FENGXue Duanying-zhong LIYong-ming LINZhu | 2003 | 口腔医学研究2003，19，2： | 3 |
| 5 | Analysis of molecular variation in porcine reproductive and respiratory syndrome virus in China between 2007 and 2012显示文摘In the present study, 89 porcine reproductive and respiratory syndrome virus(PRRSV) isolates in China during 2007 to 2012 were randomly selected from the GenBank genetic sequence database. Evolutionary characteristics of these isolates were analyzed based on the sequences of non-struc-tural protein 2(Nsp2) and glycoprotein 5(GP5). The genetic variations of the isolates were also compared with six representative strains. The results showed that a high degree of genetic diversity exists among the PRRSV population in China. Highly pathogenic PRRSV isolates, with a discon-tinuous deletion of a 30 amino acid residue in the Nsp2 region, remained the most dominant virus throughout 2007–2012 in China. Owing to the extensive use of representative vaccine strains, natu-ral recombination events occurred between strains. Three isolates – HH08, DY, and YN-2011 – were more closely related to vaccine strains than the other isolates. Both YN-2011 and DY were the evolu-tionary products of recombination events between strains SP and CH-1R. The results of the present study provide useful information for the epidemiology of PRRSV as well as for vaccine development. | Yuhang Cao Hongsheng Ouyang Mingjun Zhang Fuwang Chen Xin Yang Daxing Pang Linzhu Ren | 2014 | Virologica Sinica2014，29，3： | 2 |
| 6 | Thermo- dynamic Analysis on the Behavior of Titanium in Production Process of 95CrMo Hollow Steel显示文摘 | WANG LINZHU LI JINGSHE XIONG JIAZE | 2014 | MS and T2014，2004，1： | 1 |
| 7 | Research on Real-time Monitoring of Abnormal Seismic Noise显示文摘The noise data in vertical component records of 85 seismic stations in Fujian Province during 2012 is used as the research object in this paper. The noise data is divided into fiveminute segments to calculate the power spectra. The high reference line and low reference line of station are then identified by drawing a probability density function graph( PDF)using the power spectral probability density function. Moreover, according to the anomalies of PDF graphs in 85 seismic stations,the abnormal noise is divided into four categories: dropped packet, low noise, high noise, and median noise anomalies.Afterwards,four selection methods are found by the high or low noise reference line of the stations,and the system of real-time monitoring of seismic noise is formed by combining the four selection methods. Noise records of 85 seismic stations in Fujian Province in July2013 are selected for verification,and the results show that the anomalous noise-recognition system could reach a 90% success rate at most stations and the effect of selection are very good. Therefore,it could be applied to the seismic noise real-time monitoring in stations. | Lin Binhua Jin Xing Liao Shirong Li Jun Huang Linzhu Chen Huifang | 2016 | Earthquake Research in China2016，30，2： | 1 |
| 8 | A sweet polydopamine nanoplatform for synergistic combination of targeted chemophotothermal therapy显示文摘 | Gao Yanqin Wu Xingjie Zhou Linzhu | 2015 | Macromolecular Rapid Communications2015，36，10： | 1 |
| 9 | Expression, purification and antibody preparation using different constructs of PCV2 capsid protein显示文摘 | Fuwang Chen Xin Yang Daxing Pang Zhiyuan Peng Meichen Dong Xiaoyun Liu Hongsheng Ouyang Linzhu Ren | 2014 | International Journal of Biological Macromolecules2014，，： | 1 |
| 10 | Comparative analysis of different methods to enhance porcine circovirus 2 replication显示文摘 | Xin Yang Fuwang Chen Yuhang Cao Daxing Pang Hongsheng Ouyang Linzhu Ren | 2012 | Journal of Virological Methods2012，，： | 1 |
| 11 | STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo 显示文摘 | Chen huang Tao jiang Linzhu | 2011 | International journal of oncology2011，38，6： | 1 |
| 12 | A Three-Dimensional Silicon-Diacetylene Porous Organic Radical Polymer显示文摘Radical-containing porous organic polymers(POPs)have drawn great interest in various applications.However,the synthesis of radical POPs remains challenging due to the unstable nature of organic radicals.Here,a persistent and stable three-dimensional silicon-diacetylene porous organic radical polymer was synthesized via a classic Eglinton homocoupling reaction of tetraethynylsilane.The presence of carbon radicals in this material was confirmed by electron paramagnetic resonance,and its paramagnetic behavior was analyzed by a superconducting quantum interference device.This unique material has a low-lying lowest unoccupied molecular orbital(LUMO)energy level(−5.47 eV)and a small energy gap(ca.1.46 eV),which shows long-term cycling stability and excellent rate capability as an anode material for lithium-ion batteries,demonstrating potential application in energy fields. | Chengcheng Dong Juan Chu Linzhu Cao Fengchao Cui Shuang Liang Xintong Zhang Xin Tao Heng-guo Wang Guangshan Zhu | 2023 | CCS Chemistry2023，5，3： | 0 |
| 13 | Mink Circovirus Can Infect Minks, Foxes and Raccoon Dogs显示文摘Dear Editor,Mink circovirus (MiCV), which is clustered in the genus Circovirus of the family Circoviridae, was first described in minks from farms in Dalian, China in 2013 (Lian et al.2014). The complete single-stranded circular genome of the virus is 1,753 nucleotides long and contains two major open reading frames (ORFs), designated ORF1 (Rep gene)and ORF2 (Cap gene)(Lian et al. 2014;Ge et al. 2018). | Yanling Yang Yuening Cheng Nan Li Shipeng Cheng Li Guo Yucheng Zhou Haiwei Zhang Xinyuan Zhang Linzhu Ren | 2018 | Virologica Sinica2018，33，6： | 0 |
| 14 | Study and Application of Internal Coating Technique to Drag Reduction of the Trunk Pipeline for the West-East Gas Pipeline显示文摘Coverage layer coated in the internal wall of pipeline enables the friction drag to be reduced, the throughput and the gas transmission efficiency to be increased, the frequency of pigging and the number of the intermediate compressor station to be reduced, and the power consumption of the compressor to be decreased etc. The drag reduction is a high advanced scientific technique with outstanding economical benefit. The study and application of internal coating technique for drag reduction of 4000 km trunk pipeline in West East gas transmission pipeline (WEGTP) project are described, in which the main points are the drag reduction principle, coating process and the indoor study of this technique with own decided knowledge property right at home. | HuShixin QuShenyang LinZhu | 2004 | 工程科学(英文版)2004，2，4： | 0 |
| 15 | Low-cost oriented preparation of ultra fine xonotlite fibers显示文摘Nanometer-sized xonotlite fibers have great potential application in many fields. The traditional method of preparing ultra fine xonotlite fibers uses the ultra fine and highly active silica as the major raw materials, which is not only expensive but also difficult to prepare the xonotlite fibers with diameters around 100 nm. In this study, the ultra fine xonotlite fibers with diameters around 100 nm were prepared by an autoclaving method. The preparation was low-cost oriented by using natural powder quartz and lime as the major raw materials. The intergrowth of the fibers formed thin shell hollow balls or ellipsoids, namely the secondary particles.The length of the nanometer-sized xonotlite fibers was around several microns. The fibers and their secondary particles were produced at 216℃ for 6 h with a continuous stirring of 300-500 r/min. Zirconium oxychloride was used as an additive. The experiments show that zirconium oxychloride has an enormous effect on the growing habit of xonotlite crystals and plays an important role in controlling the diameter of the xonotlite fibers. | WenNi ShuxiangChen LinZhu | 2004 | Journal of University of Science and Technology Beijing2004，11，4： | 0 |
| 16 | What should we do about monkeypox?显示文摘Over the past 3 years,the COVID-19 pandemic has posed a significant global challenge to the public health system.However,other diseases,such as hepatitis of unknown origin in children and monkeypox,have been recently reported in European,African,and American countries.These data showed that monkeypox and other emerging or re-emerging viruses are novel global threats. | Si Chen Xue Li Liying Zhang Linzhu Ren | 2022 | Animal Models and Experimental Medicine2022，5，5： | 0 |
| 17 | Agglomeration behavior of rare earth inclusions and alumina inclusions at the interface between argon and molten steel显示文摘Nozzle clogging frequently occurs in steel containing rare earth(RE) due to the aggregation of RE inclusions,which seriously interferes with the application of RE in steel.To provide insights into nozzle clogging,the agglomeration be havior of inclusions in RE-containing steel was investigated by laboratory experiments and theoretical calculations.High-temperature confocal laser scanning microscopy(HTCLSM) was applied to observe the behavior of inclusions at molten steel surfaces and their interactive forces.Kralchevsky-Paunov(K-P) model was used to predict the capillary force acting on different inclusions.The results show that the interactive forces that acted on inclusions were investigated as a function of inclusion size,inter-distance,and inclusion composition.It is found that the capillary force acting on the inclusions decreases in the order of Ce_(2)O_(3)> CeAlO_(3)> Al_(2)O_(3).This study verified the applicability of the K-P model in RE-containing steel,which can provide theoretical support to help solve the nozzle clogging problem during rare earth steel production. | Jun Wang Linzhu Wang Changrong Li Yongqiang Zhai | 2023 | Journal of Rare Earths2023，41，12： | 0 |
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