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| 1 | Protic vs aprotic ionic liquid for CO2 fixation:A simulation study显示文摘The cycloaddition of CO2 with epoxides catalyzed by ionic liquids(ILs)has been a widely ongoing studied hot topic over the years.Recent experimental research has shown that the protic ionic liquids(PILs)behave stronger hydrogen proton donating ability than aprotic ionic liquids(APILs),and can effectively catalyze the cycloaddition of CO2.Unfortunately,the mechanistic explanation remains primarily unraveled.Herein,a detailed simulation study on the cycloaddition reaction catalyzed by PIL([HDBU][Mim])in comparison with APIL([MeDBU][Mim])re-action catalysts was conducted,including the three-step route(ring-opening of PO(propylene oxide),insertion of CO2 and ring-closure of propylene carbonate(PC))and two-step route(simultaneously ring-opening of PO and addition of CO2,and then ring-closure of PC).Based on the activation energy barrier of the rate-determining step,PIL preferentially activates PO as the optimal route for the reaction with the energy barrier of 23.2 kcal mol-1,while that of APIL is 31.2 kcal mol-1.The role of[HDBU]+in the reaction was also explored and found that the direct formation of intermolecular hydrogen bond(H-bond)between[HDBU]+and the reactants(PO+CO2)was unfavorable for the reaction,while the cooperation with the anion[Mim]-to assist indirectly was more conducive.To fully consider the reaction microenvironment of ILs,ONIOM calculation was used to study the solvent effect.At last,the above conclusions were further verified by the analysis of intermediates with charge,non-covalent interaction(NCI),and atoms in molecules(AIM)methods.The computational findings show that ILs studied in this work have dual functions of catalyst and solvent,enabling a microscopic understanding of the ILs catalyst for CO2 utilization as well as providing guidance for the rational design of more efficient ILs-based catalysts. | Wenzhong Sun Meichen Wang Yaqin Zhang Weilu Ding Feng Huo Li Wei Hongyan He | 2020 | Green Energy & Environment2020，5，2： | 4 |
| 2 | Hydrochemical characteristics and water quality evaluation of shallow groundwater in Suxian mining area,Huaibei coalfield,China显示文摘The aim of this study is to evaluate the hydrogeochemical characteristics and water environmental quality of shallow groundwater in the Suxian mining area of Huaibei coalfield,China.The natural formation process of shallow groundwater in Suxian is explored using Piper trilinear charts and Gibbs diagrams,and by examining the ratios between the major ions.United States Salinity Laboratory(USSL)charts,Wilcox diagrams,and the water quality index(WQI)are further employed to quantify the differences in water quality.The results reveal that the main hydrochemical facies of groundwater are HC03-Ca,and that silicate dissolution is the main factor controlling the ion content in shallow groundwater.The USSL charts and Wilcox diagrams show that most of the water samples would be acceptable for use in irrigation systems.The WQI results for each water sample are compared and analyzed,and the quality of groundwater samples around collapse ponds is found to be relatively poor. | Hao Yu Herong Gui Honghai Zhao Meichen Wang Jun Li Hongxia Fang Yaqi Jiang Yaru Zhang | 2020 | International Journal of Coal Science & Technology2020，7，4： | 3 |
| 3 | Regulation of innate immune responses by rabies virus显示文摘Rabies virus(RABV)is an infectious and neurotropic pathogen that causes rabies and infects humans and almost all warm-blooded animals,posing a great threat to people and public safety.It is well known that innate immunity is the critical first line of host defense against viral infection.It monitors the invading pathogens by recognizing the pathogen-associated molecular patterns and danger-associated molecular patterns through pattern-recognition receptors,leading to the production of type I interferons(IFNα/β),inflammatory cytokines,and chemokines,or the activation of autophagy or apoptosis to inhibit virus replication.In the case of RABV,the innate immune response is usually triggered when the skin or muscle is bitten or scratched.However,RABV has evolved many ways to escape or even hijack innate immune response to complete its own replication and eventually invades the central nervous system(CNS).Once RABV reaches the CNS,it cannot be wiped out by the immune system or any drugs.Therefore,a better understanding of the interplay between RABV and innate immu-nity is necessary to develop effective strategies to combat its infection.Here,we review the innate immune responses induced by RABV and illustrate the antagonism mechanisms of RABV to provide new insights for the control of rabies. | Haili Zhang Jingbo Huang Yumeng Song Xingqi Liu Meichen Qian Pei Huang Yuanyuan Li Ling Zhao Hualei Wang | 2022 | Animal Models and Experimental Medicine2022，5，5： | 2 |
| 4 | Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice显示文摘Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression.Discs large homolog 1(Dlg1),an adaptor protein,regulates cell polarization and the function of K?channels,which are reported to regulate the activation of microglia.However,little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis.In this study,we found that Dlg1 knockdown suppressed lipopolysaccharide(LPS)-induced inflammation by downregulating the activation of nuclear factor-jB signaling and the mitogen-activated protein kinase pathway in microglia.Moreover,using an inducible Dlg1 microglia-specific knockout(Dlg1flox/flox;CX3CR1CreER)mouse line,we found that microglial Dlg1 knockout reduced the activation of microglia and alleviated the LPS-induced depressionlike behavior.In summary,our results demonstrated that Dlg1 plays a critical role in microglial activation and thus provides a potential therapeutic target for the clinical treatment of depression. | Zhixin Peng Xiaoheng Li Jun Li Yuan Dong Yuhao Gao Yajin Liao Meichen Yan Zengqiang Yuan Jinbo Cheng | 2021 | Neuroscience Bulletin2021，37，12： | 2 |
| 5 | Alizarin-TiO2 LMCT Complex with Oxygen Vacancies:An Efficient Visible Light Photocatalyst for Cr(Ⅵ)Reduction显示文摘of main observation and conclusion The AL-P25 composites(AL=alizarin,P25=nano titanium dioxide)with oxygen vacancies were synthesized by a simple hydrothermal method and applied for the photoreduction of Cr(VI)under visible light.The AL-P25 composites were characterized by scanning electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy analysis,Fourier transform infrared spectrometer,thermo-gravimetric analysis,UV-vis diffuse reflectance spectroscopy,photoluminescence spectroscopy and electron paramagnetic resonance spectroscopy.The results suggested that the AL-P25 composites were successfully prepared,and alizarin was linked to P25 via Ti—O—C bonds.AL-P25 composites represented excellent photoreduction efficiency on Cr(VI)under visible light,which was 99.4%after 60 min of illumination.Finally,a photocatalytic mechanism of AL-P25 composites was proposed that ligand-metal charge transfer(LMCT)process between alizarin and P25 effectively enhances separation efficiency of photogenerated electrons and holes. | Meichen Li Yarn Li Jingyu Zhao Mingcheng Li Yongchuan Wu Ping Na | 2020 | Chinese Journal of Chemistry2020，38，11： | 2 |
| 6 | Novel multi–SO_(3)H functionalized ionic liquids as highly efficient catalyst for synthesis of biodiesel显示文摘Biodiesel is an attractive alternative to fossil fuels due to the energy and environmental concerns. In this paper, seven different multi –SO_(3)H functionalized ILs based on the low-cost less-substituted amines, which contained massive sites for functionalization of sulfonic acid groups and further treatment of sulfonate-based anions, were prepared as catalysts with high acidity and desirable catalytic activity for the synthesis of biodiesel from the esterification of oleic acid with methanol. The physicochemical properties of these acidic ILs were characterized by a variety of analytical techniques such as FT-IR, EA, TGA, and the Br?nsted acidity was well determined by UV–vis. Among the ILs prepared, [EDA-PS][P-TSA] showed the highest catalytic activity for esterification due to its high acidity and appropriate miscibility with reactants, with an ultrahigh97.58% conversion of oleic acid under the optimum conditions(i.e. reaction time, 1.8 h;catalyst amount, 3 wt%;alcohol/acid molar ratio, 13:1,temperature 70℃) acquired from the Box–Behnken response surface methodology. With the novel strategy of multi –SO_(3) H modification on ILs,our catalyst had an approaching or even superior oleic acid conversion rate compared to other reported catalysts with considerably lower catalyst dosage and shorter reaction time. More importantly, it also exhibited high generality for converting various FFA feedstocks into biodiesel with considerable conversion within 93.59–94.33% under a rather lower catalyst dosage, which showed the valuable potential for converting low-cost oils into biodiesel from an economic and environmental perspective. | Meichen Li Jie Chen Ling Li Changshen Ye Xiaocheng Lin Ting Qiu | 2021 | Green Energy & Environment2021，6，2： | 1 |
| 7 | A Secure Three-Factor Authenticated Key Agreement Scheme for Multi-Server Environment显示文摘Multi-server authenticated key agreement schemes have attracted great attention to both academia and industry in recent years.However,traditional authenticated key agreement schemes in the single-server environment are not suitable for the multi-server environment because the user has to register on each server when he/she wishes to log in various servers for different service.Moreover,it is unreasonable to consider all servers are trusted since the server in a multi-server environment may be a semi-trusted party.In order to overcome these difficulties,we designed a secure three-factor multi-server authenticated key agreement protocol based on elliptic curve cryptography,which needs the user to register only once at the registration center in order to access all semi-trusted servers.The proposed scheme can not only against various known attacks but also provides high computational efficiency.Besides,we have proved our scheme fulfills mutual authentication by using the authentication test method. | Meichen Xia Shiliang Li Liu Liu | 2020 | Computers, Materials & Continua2020，，9： | 1 |
| 8 | Sealing reliability modeling of aviation seal based on interval uncertainty method and multidimensional response surface显示文摘Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar due to the appearance of small-sample parameters. In this study, the sealing reliability of an aviation seal was defined as the research object, and an interval uncertainty method and multidimensional response surface were proposed to calculate the sealing reliability.Based on this, we first analyzed the failure mechanism of the aviation seal and established a leakage rate model. Then, based on the non-probabilistic interval model, an interval uncertainty method was proposed to construct the analytical model. With reference to the limit state equation from the structural reliability theory, the multidimensional response surface was used for fast calculation.Then, we chose the single-cylinder gas steering gear used in aircraft as the case study, its sealing reliability in working and non-working statuses were calculated, and the results were verified with the actual maintenance records. By analyzing the sensitivity of some variables, we can improve the sealing reliability of the aviation seal by improving the surface roughness only if the cost allows.Finally, we consider that the method proposed in this study realizes the application of smallsample uncertainty analysis in reliability analysis, and could provide a feasible way to solve the similar problems in engineering with multidimensional and small-sample parameters. | Baopeng LIAO Bo SUN Yu LI Meichen YAN Yi REN Qiang FENG Dezhen YANG Kun ZHOU | 2019 | Chinese Journal of Aeronautics2019，32，9： | 1 |
| 9 | Coculture engineering for efficient production of vanillyl alcohol in Escherichia coli显示文摘Vanillyl alcohol is a precursor of vanillin,which is one of the most widely used flavor compounds.Currently,vanillyl alcohol biosynthesis still encounters the problem of low efficiency.In this study,coculture engineering was adopted to improve production efficiency of vanillyl alcohol in E.coli.First,two pathways were compared for biosynthesis of the immediate precursor 3,4-dihydroxybenzyl alcohol in monocultures,and the 3-dehydroshikimate-derived pathway showed higher efficiency than the 4-hydroxybenzoate-derived pathway.To enhance the efficiency of the last methylation step,two strategies were used,and strengthening S-adenosylmethionine(SAM)regeneration showed positive effect while strengthening SAM biosynthesis showed negative effect.Then,the optimized pathway was assembled in a single cell.However,the biosynthetic efficiency was still low,and was not significantly improved by modular optimization of pathway genes.Thus,coculturing engineering strategy was adopted.At the optimal inoculation ratio,the titer reached 328.9 mg/L.Further,gene aroE was knocked out to reduce cell growth and improve 3,4-DHBA biosynthesis of the upstream strain.As a result,the titer was improved to 559.4 mg/L in shake flasks and to 3.89 g/L in fed-batch fermentation.These are the highest reported titers of vanillyl alcohol so far.This work provides an effective strategy for sustainable production of vanillyl alcohol. | Meichen Yang Hao Meng Xianglai Li Jia Wang Xiaolin Shen Xinxiao Sun Qipeng Yuan | 2022 | aBIOTECH2022，3，4： | 1 |
| 10 | Incorporation of Escherichia coli heat-labile enterotoxin B subunit into rabies virus particles enhances its immunogenicity in mice and dogs显示文摘Although inactivated vaccines against rabies have the advantage of high safety,effective protection against rabies virus(RABV)infection often requires multiple,high-dose immunization.Incorporating a molecular adjuvant into the viral particles has been found to be a useful strategy to promote the immune effectiveness of inactivated vaccines.In this study,we constructed a recombinant virus,rCVS11-LTB,which chimerically expresses a molecular adjuvant heat-labile enterotoxin B subunit(LTB)protein on the surface of the RABV particles.Immunogenicity in vivo was found to be promoted by rCVS11-LTB through the activation of dendritic cells(DCs).Our results demonstrated that inactivated rCVS11-LTB was able to induce higher levels of virusneutralizing antibodies(VNAs)in both mice and dogs than the parent virus rCVS11,to enhance the cellular immune response and T cell immune memory in mice,and was also able to provide 100%protection in mice from lethal doses of rabies virus,indicating its potential as a safe and effective inactivated rabies vaccine candidate. | Zhiyuan Gong Hailun Li Meichen Qian Yujie Bai Hongli Jin Jingxuan Sun Mengyao Zhang Cuicui Jiao Pei Huang Yuanyuan Li Haili Zhang Hualei Wang | 2023 | Biosafety and Health2023，5，5： | 0 |
| 11 | Regulation of hydrogen evolution performance of titanium oxide-carbon composites at high current density with a Ti-O hybrid orbital显示文摘Rational design and controllable synthesis of practical electrodes with high sta bility and activity at high current density for a hydrogen evolution reaction(HER)are critical for renewable and sustainable energy conversion.However,high-performance TiO_(2)-based electrocatalysts for HER are quite limited,and the cat alytic active centers still remain elusive.Herein,a simple strategy is demonstrated for the synthesis of TiO_(2)-carbon composite(TiO_(2)/C)with high HER performance and stability.The remarkable HER performance of TiO_(2)/C can be ascribed to the doping of carbon atoms,which leads to stronger hybridization of Ti 3d and O 2p orbitals,thus substantially improving the electrocatalytic efficiency.This study elucidates that the hydrogen evolution activity of oxide electrocatalysts can be largely improved by regulating their electronic structures by doping carbon atoms and also provides an effective strategy for designing heterostructured electro catalysts with high catalytic activity and stability at high current density for HER. | Meichen Liu Zhiping Lei Qingping Ke Peixin Cui Jiancheng Wang Jingchong Yan Zhanku Li Hengfu Shui Shibiao Ren Zhicai Wang Ying Kong Shigang Kang | 2022 | Carbon Energy2022，4，3： | 0 |
| 12 | Dose-Response Meta-Analysis on Risk of Diabetes in Relation to Red and Processed Meat Consumption—Asian Populations,2006−2021显示文摘Summary What is already known about this topic?Red and processed meat consumption has been positively related to an increased risk of diabetes in Western populations.However,the results remain inconclusive within Asian populations.What is added by this report?This dose-response meta-analysis of prospective cohort studies conducted in East Asian populations reveals a positive relation between the consumption of processed meat and increased risk of diabetes.Furthermore,a Ushaped association was identified between the consumption of unprocessed red meat and the risk of diabetes.What are the implications for public health practice?This research presents substantive evidence advocating for the reduction of processed and unprocessed red meat consumption as a viable strategy for mitigating the risk of diabetes in East Asian populations. | Hancheng Yu Jijuan Zhang Jinchi Xie Xianli Li Youjing Wang Yijia Yang Fengshuang Zhou Meichen Liu Zhe Zhang Zhilei Shan Gang Liu An Pan | 2023 | China CDC weekly2023，5，45： | 0 |
| 13 | BnbHLH92a negatively regulates anthocyanin and proanthocyanidin biosynthesis in Brassica napus显示文摘Yellow seed trait is a desirable characteristic with potential for increasing seed quality and commercial value in rapeseed,and anthocyanin and proanthocyanidins(PAs)are major seed-coat pigments.Few transcription factors involved in the regulation of anthocyanin and PAs biosynthesis have been characterized in rapeseed.In this study,we identified a transcription factor gene BnbHLH92a(BnaA06T0441000ZS)in rapeseed.Overexpressing BnbHLH92a both in Arabidopsis and in rapeseed reduced levels of anthocyanin and PAs.Correspondingly,the expression profiles of anthocyanin and PA biosynthesis genes(TT3,BAN,TT8,TT18,and TTG1)were shown by quantitative real-time PCR to be inhibited in BnbHLH92a-overexpressing Arabidopsis seeds,indicating that BnbHLH92a represses the anthocyanin and PA biosynthesis pathway in Arabidopsis.BnbHLH92a physically interacts with the BnTTG1 protein and represses the biosynthesis of anthocyanins and PAs in rapeseed.BnbHLH92a also binds directly to the BnTT18 promoter and represses its expression.These results suggest that BnbHLH92a is a novel upstream regulator of flavonoid biosynthesis in B.napus. | Ran Hu Meichen Zhu Si Chen Chengxiang Li Qianwei Zhang Lei Gao Xueqin Liu Shulin Shen Fuyou Fu Xinfu Xu Ying Liang Liezhao Liu Kun Lu Hao Yu Jiana Li Cunmin Qu | 2023 | The Crop Journal2023，11，2： | 0 |
| 14 | Magnesium Demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress显示文摘Cantharidin(CTD)is a bioactive ingredient isolated from Cantharis vesicatoria(blister beetles),which has potential therapeutic value as an anticancer agent.Magnesium Demethylcantharidate(MDC)is a recently developed derivative of Cantharidin(CTD),and previous studies have illustrated its excellent anticancer activity on HCC cells.However,the effect and mechanism of MDC remains unclear and need to be further studied.In particular,whether MDC can cause ER stress in HCC is still unknown.In this study,we demonstrated that endoplasmic reticulum stress(ERS)-related proteins were changed in SMMC-7721 and Bel-7402 cells after being exposed to MDC.Moreover,we found that MDC could significantly inhibit the growth of xenograft tumor in nude mice.In summary,we confirmed that MDC could induce ERS in HCC cells and thus induce apoptosis. | XINTING ZHU MENG YE KELAN FANG FANG LIU JING HUI MEICHEN LIU XIAOFEI LI RONG YAN YUN LIU | 2022 | BIOCELL2022，46，12： | 0 |
| 15 | The morphological evolution of Chinese urban cemeteries from the perspective of fringe belt:A case study of Nanjing显示文摘The urban cemetery is the material carrier of citizens’view of life and death,and it also evolves with time as a special part of the urban form.Since the reform of the housing system in the 1990s,China has entered a period of rapid urbanization,and the urban cemeteries has entered a cycle of shock and accelerated transformation.The cemeteries originally located on the urban fringe were gradually surrounded by new built-up areas as the city sprawled,and then most of them inevitably migrated outward under the pressure of urban population explosion and land shortage.Taking Nanjing as an example,this paper presents the morphological evolution of Nanjing’s urban cemetery since the early 20th century,discusses the relationship between the evolution of the cemetery and the urban fringe belt,and analyzes the reasons for its evolution.The different types of morphological evolution of Nanjing cemetery are further summarized,revealing the general law and its Chinese particularity.The article concludes with a discussion of the value and significance of morphological research on urban cemeteries in China. | Hao Deng Meichen Li | 2023 | Frontiers of Architectural Research2023，12，6： | 0 |
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