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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation显示文摘AIM:To investigate whether the inhibition of autophagy by chloroquine(CQ)sensitizes rectal tumors to radiation therapy(RT)or concurrent chemoradiation(chemoRT).METHODS:In vitro,HCT-116 and HT-29 colorectal cancer(CRC)cell lines were treated as following:(1)PBS;(2)CQ;(3)5-fluorouracil(5-FU);(4)RT;(5)CQ and RT;(6)5-FU and RT;(7)CQ and 5-FU;and(8)5-FU and CQ and RT.Each group was then exposed to various doses of radiation(0-8 Gy)depending on the experiment.Cell viability and proliferative capacity were measured by3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and clonogenic assays.Clonogenic survivalcurves were constructed and compared across treatment groups.Autophagy status was determined by assessing the LC3-Ⅱto LC3-Ⅰratio on western blot analysis,autophagosome formation on electron microscopy and identification of a perinuclear punctate pattern with GFPlabeled LC3 on fluorescence microscopy.Cell cycle arrest and cell death were evaluated by FACS and AnnexinⅤanalysis.All experiments were performed in triplicate and statistical analysis was performed by the student’s t test to compare means between treatment groups.RESULTS:RT(2-8 Gy)induced autophagy in HCT-116and HT-29 CRC cell lines at 4 and 6 h post-radiation,respectively,as measured by increasing LC3-Ⅱto LC3-Ⅰratio on western blot.Additionally,electron microscopy demonstrated autophagy induction in HT-29 cells24 h following irradiation at a dose of 8 Gy.Drug treatment with 5-FU(25μmol/L)induced autophagy and the combination of 5-FU and RT demonstrated synergism in autophagy induction.CQ(10μmol/L)alone and in combination with RT effectively inhibited autophagy and sensitized both HCT-116 and HT-29 cells to treatment with radiation(8 Gy;P<0.001 and 0.00001,respectively).Significant decrease in clonogenic survival was seen only in the HT-29 cell line,when CQ was combined with RT at doses of 2 and 8 Gy(P<0.5 and P=0.05,respectively).There were no differences in cell cycle progression or Annexin V staining upon CQ addition to RT.CONCLUSION:Autophagy inhibition by CQ increases CRC cell sensitivity to concurrent treatment with 5-FU and RT in vitro,suggesting that addition of CQ to chemoRT improves CRC treatment response. | Caitlin A Schonewolf Monal Mehta Devora Schiff Hao Wu Bruce G Haffty Vassiliki Karantza Salma K Jabbour | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 12 |
| 3 | Effect of preoperative biliary drainage on outcome of classical pancreaticoduodenectomy显示文摘AIM: To investigate the role of preoperative biliary drainage (PBD) in the outcome of classical pancreaticodu odenectomy. METHODS: A 10-year retrospective data analysis was performed on patients (n = 48) undergoing pancreaticoduodenectomy from March 1994 to March 2004 in department of surgery at SMS medical college, Jaipur, India. Demographic variables, details of preoperative stenting, operative procedure and post operative complications were noted. RESULTS: Preoperative biliary drainage was performed in 21 patients (43.5%). The incidence of septic complications was significantly higher in patients with biliary stent placement (P < 0.05, 0 vs 4). This group of patients also had a significantly higher minor biliary leak rate. Mortality and hospital stay in each group was comparable. CONCLUSION: Within this study population the use of PBD by endoscopic stenting was associated with a high incidence of infective complications. These findings do not support the routine use of biliary stenting in patients prior to pancreatico-duodenectomy. | Chandra Shekhar Bhati Chandrashekhar Kubal Pankaj Kumar Sihag Ankur Atal Gupta Raj Kamal Jenav Nicholas G Inston Jagdish M Mehta | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 4 | Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2+ influx显示文摘 | Jho D Mehta D Ahmmed G Gao XP Tiruppathi C Broman M | 2005 | Circ Res2005，96，12： | 1 |
| 5 | Surgical treatment of lumbar tuberculous spondylodiscitis by transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation显示文摘 | Zaveri G R Mehta S S | 2009 | J Spinal Disord Tech2009，22，4： | 1 |
| 6 | Early predictive bio- markers for postpartum depression point to a role for estrogen re- ceptor signaling显示文摘 | Mehta D Newport D J Frishman G | 2014 | Psychol Med2014，44，11： | 1 |
| 7 | Pheno: typic characterization and identification of effector cells involved in tunor cell recognition of cytokine induced kil- ler cells显示文摘 | Schmidt-Wolf I G Lefterova P Mehta B A | 1993 | Exp Hematol1993，21，13： | 1 |
| 8 | Low-dose vsstandard-dose un-fractionated heparin for percutaneous coro-nary intervention in acute coronary syndromes treated withfondaparinux:the FUTURA/OASIS-8randomized trial显示文摘 | STEG P G JOLLY S S MEHTA S R | 2010 | JAMA2010，304，12： | 1 |
| 9 | High density polyethylene-g-maleic anhydride preparation in presence of electrondonors 显示文摘 | GAYLORD N G MEHTA R KUMAR V | 1989 | J Appl Polym Sci1989，38，2： | 1 |
| 10 | Extracellular electron trnasfer via microbial nanowires显示文摘 | Reguera G McCarthy KD Mehta T | 2005 | Nature2005，435，7045： | 1 |
| 11 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 12 | Impact of transtradial and transfemoral coronary interventions on bleeding and net adverse clinical events in acute coronary syndromes显示文摘 | Hamon M Mehta S Steg P G | 2011 | Eurointervention2011，7，1： | 1 |
| 13 | Prospective evaluation of radiosurgery for hemangioblastomas in von HippelLindau disease显示文摘 | Asthagiri A R Mehta G U Zach L | 2010 | Neuro Oncol2010，12，1： | 1 |
| 14 | Mandibular Reconstruction in 2004: an Analysis of Different Techniques显示文摘 | Mehta R P Deschler D G | 2004 | Curr Opin Otolaryngol Head Neck Sury2004，12，4： | 1 |
| 15 | Extracellular electron transfer via microbial nanowires 显示文摘 | Reguera G Mccarthy K D Mehta T | 2005 | Nature2005，435，： | 1 |
| 16 | Convenient synthesis of Valsartan via aSuzuki reaction显示文摘 | Ghosh S Kumar A S Mehta G N | 2010 | Journal of Chemical Research2010，，4： | 1 |
| 17 | Extracellular electron transfer via microbial nanowires 显示文摘 | Reguera G McCarthy K D Mehta T | 2005 | Nature2005，435，： | 1 |
| 18 | Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1 -dependent Ca2+ influ显示文摘 | Jho D Mehta D Ahmmed G | 2005 | Circ Res2005，96，12： | 1 |
| 19 | Cruciferous Vegetables and Cancer Prevention显示文摘 | Murillo G Mehta RG | 2001 | Nutrition and Cancer2001，41，1： | 1 |
| 20 | CSF interleukin-1 beta,tumor necrosis factor-alpha and free radicals production in relation to clinical outcome in acute baeterial meningitis显示文摘 | JAIN M ANEJA S MEHTA G | 2000 | Indian Pediatr2000，37，6： | 1 |
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