|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 3 | Aminotransferases:demonstration of homology and division into evolutionary subgroups显示文摘 | Hale T I and Christen P | 1993 | Eur J Biochem1993，214，： | 1 |
| 4 | Predicting death in patients with acute type a aortic dissection显示文摘 | Mehta RH Suzuki T Hagan PG | 2002 | Circulation2002，105，： | 1 |
| 5 | Predicting deathin patients with acute a aortic dissection显示文摘 | Mehta RH Suzuki T Hagan PG | 2002 | Circulation2002，105，2： | 1 |
| 6 | Clinical profiles and outcomes of acute type B aortic dissection in the current erat lessons from the international registry of aortic dissection(IRAD) 显示文摘 | Suzki T Mehta R H Ine H | 2003 | Circulation2003，108，11： | 1 |
| 7 | Soluble monomeric P - selectin containing only the lectin and epidermal growth factor domains binds to P - selectin glycoprotein ligand - 1 on leukocytes 显示文摘 | MEHTA P PATEL K D LAUE T M | 1997 | Blood1997，90，6： | 1 |
| 8 | Poly ( amidoamine ) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy 显示文摘 | Majoros I J Thomas T P Mehta C B | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 9 | Dose comparisons of clopidogrel and aspirin in acute coronary Syndromes显示文摘 | CURRENT-OASIS T Investigators MEHTA SR BASSAND JP | 2010 | N Engl J Med2010，363，3： | 1 |
| 10 | The Human Hematopoietic Progenitor Cell Antigen (CD34) in Vascular Neoplasia显示文摘 | Traweek S T Kandalaft P L Mehta P | 1991 | Am J Clin Pathol1991，96，1： | 1 |
| 11 | The multi-ob- jective equilibrium network design problem revisited: a simulated annealing approach显示文摘 | Friesz T L Mehta N J Nam K | 1993 | European Journal of Operational Research1993，65，1： | 1 |
| 12 | Extracellular electron trnasfer via microbial nanowires显示文摘 | Reguera G McCarthy KD Mehta T | 2005 | Nature2005，435，7045： | 1 |
| 13 | The effect of EGR on low-speed pre-ignition in boosted SI engines显示文摘 | Amann M Alger T Mehta D | | 0，，01： | 1 |
| 14 | Extracellular electron transfer via microbial nanowires 显示文摘 | Reguera G Mccarthy K D Mehta T | 2005 | Nature2005，435，： | 1 |
| 15 | Genetic variation of antigen processing machinery components and association with cerivical carcinoma 显示文摘 | Mehta A M Jordanova E S Van Wezel T | 2007 | Genes Chromosomes Cancer2007，46，： | 1 |
| 16 | Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis,respectively, in HL-60 cells显示文摘 | Mehta K McQueen T Neamati N | 1996 | Cell Growth Diff1996，7，2： | 1 |
| 17 | Stent-within-a-stent technique for the treatment of dissecting verlebral artery aneurysms显示文摘 | Mehta B Burke T Kole M | 2003 | Am J Neuroradiol2003，24，11： | 1 |
| 18 | Extracellular electron transfer via microbial nanowires 显示文摘 | Reguera G McCarthy K D Mehta T | 2005 | Nature2005，435，： | 1 |
| 19 | A cell pene-ating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt 显示文摘 | Mehta RR Yamada T Taylor BN | 2011 | Angiogenesis2011，14，3： | 1 |
| 20 | Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy显示文摘 | MAJOROS I J THOMAS T P MEHTA C B | | 0，，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员