4篇
您的检索式：作者名="Megan COOK"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overview of extended release tacrolimus in solid organ transplantation显示文摘Tacrolimus(Prograf?, Astellas Pharma Europe Ltd, Staines, United Kingdom; referred to as tacrolimusBID) is an immunosuppressive agent to prevent and treat allograft rejection in kidney transplant recipients in combination with mycophenolate mofetil, corticosteroids,with or without basiliximab induction. The drug has also been studied in liver, heart and lung transplant; however, these are currently off-label indications. An extended release tacrolimus formulation(Advagraf?, Astagraf XL?) allows for once-daily dosing, with the potential to improve adherence. Extended release tacrolimus has similar absorption, distribution, metabolism and excretion to tacrolimus-BID. Phase Ⅰ pharmacokinetic trials comparing extended release tacrolimus and tacrolimus-BID have demonstrated a decreased maximum concentration(C max) and delayed time to maximum concentration(t max) with the extended release formulation; however, AUC0-24 was comparable between formulations. Overall extended release tacrolimus has a very similar safety and efficacy profile to tacrolimus-BID. It is not recommended in the use of liver transplant patient's due to the increased risk of mortality in female recipients. There has been minimal data regarding the use of extended release tacrolimus in heart and lung transplant recipients. With the current data available for all organ groups the extended release tacrolimus should be dosed in a 1:1 fashion, the exception may be the cystic fibrosis population where their initial dose may need to be higher. | Neha Patel Abigail Cook Elizabeth Greenhalgh Megan A Rech Joshua Rusinak Lynley Heinrich | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 2 | Peritoneal elastic lamina invasion: Limitations in its use as a prognostic marker in stage II colorectal cancer显示文摘 | Andrea Grin David E. Messenger Megan Cook Brenda I. O’Connor Sara Hafezi Hala El-Zamaity Richard Kirsch | 2013 | Human Pathology2013，，： | 1 |
| 3 | Venous Invasion in Colorectal Cancer: Impact of an Elastin Stain on Detection and Interobserver Agreement Among Gastrointestinal and Nongastrointestinal Pathologists显示文摘 | Richard Kirsch David E. Messenger Robert H. Riddell Aaron Pollett Megan Cook Sahar Al-Haddad Catherine J. Streutker Dimitrios X. Divaris Rajani Pandit Ken J. Newell Jimin Liu Russell G. Price Sharyn Smith Jeremy R. Parfitt David K. Driman | 2013 | The American Journal of Surgical Pathology2013，，2： | 1 |
| 4 | Optimal Port Design Minimizing Standing Waves with A Posteriori Long Term Shoreline Sustainability Analysis显示文摘Optimization theory is applied to a coastal engineering problem that is the design of a port.This approach was applied to the redesign of La Turballe Port in order to increase the exploitable surface area and simultaneously reduce the occurrence of long waves within the port.Having defined the cost function as a weighted function of wave amplitude and with the chosen parameterization of the port,results show that an extended jetty and a widened mole yield a unique optimal solution.This work demonstrates that numerical optimization may be quick and efficient in the identification of port solutions consistent with classic engineering even in the context of complex problems. | Megan COOK Frédéric BOUCHETTE Bijan MOHAMMADI Léa SPRUNCK Nicolas FRAYSSE | 2021 | China Ocean Engineering2021，35，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员