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| 1 | Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo显示文摘Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully understood.Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner.The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen deficiency.Estrogen replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four weeks.Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo.Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling. | Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu | 2011 | Protein & Cell2011，2，4： | 8 |
| 2 | Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice显示文摘雌激素缺乏调停变老,但是内在的机制尚待充分坚定。我们这里报导 aromatase 的指向的混乱在老鼠引起的雌激素缺乏在 vivo 在肾上腺导致 telomerase 活动的重要抑制。基因表示分析证明当雌激素不在时, telomerase 颠倒 transcriptase (TERT ) 基因表示在肾上腺外皮和肾的萎缩与损害房间增长联合被减少。在 c 工具包积极的干细胞被识别在肾的外皮的实质占据。telomeres 的分析表明那雌激素缺乏比那在肾的外皮导致显著地更短的 telomeres 在野类型(WT ) 控制鼠标。为了推进,建立雌激素的原因的效果,我们在这些雌激素缺乏的动物进行了雌激素代替治疗。为 3 个星期的雌激素的管理在雌激素缺乏的老鼠恢复 TERT 基因表示, telomerase 活动和房间增长。因此,我们第一次,那雌激素缺乏在 vivo 在鼠标的肾上腺引起 TERT 基因表示, telomerase 活动, telomere 维护,和房间增长的抑制的数据表演,建议那 telomerase 抑制并且 telomere 弄短可以调停在肾上腺的房间增长拘捕,因此贡献雌激素在生理的条件下面的导致缺乏的老化。 | Sharyn Bayne Margaret EE Jones He Li Alex R Pinto Evan R Simpson Jun-Ping Liu | 2008 | Cell Research2008，18，11： | 6 |
| 3 | 梅毒与血液供者显示文摘梅毒由苍白螺旋体(T Pamdum)引起,一般经性接触传播,其他传播方式相当少见.1915年首次报道梅毒经输血传播,献血者作梅毒血清学检测已有60年的历史,美国已有30多年未报道输血传播梅毒. | Sharyn Orton 梁晓虎 | 2002 | 国外医学(输血及血液学分册)2002，25，1： | 4 |
| 4 | Phase I and pharmaokinetie study of GI147211, a water-soluble camptothecin analogue, administered for five consecutive days every three weeks显示文摘 | Eckhardt SG Sharyn DB John R E | 1998 | Clinical Catwer Research1998，4，： | 1 |
| 5 | Global Identification of Targets of the Arabidopsis MADS Domain Protein AGAMOUS-Like15(C)(W)显示文摘 | Zheng Yumei Ren Na Wang Huai Stromberg Arnold J Perry Sharyn E | 2009 | Plant Cell2009，，9： | 1 |
| 6 | Exploring loyal qualities: Assessing survey - based loyalty measure显示文摘 | Sharyn R T | 2005 | Journal of Services Marketing2005，19，7： | 1 |
| 7 | Nonspecific interstitial pneumonia and usual interstitial pneumonia:comparative appearances at and diagnostic accuracy of thin-section CT显示文摘 | David MH Sharyn LSM Michael BR | | 0，，03： | 1 |
| 8 | Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy显示文摘 | Thomas J. Borody Eloise F. Warren Sharyn Leis Rosa Surace Ori Ashman | 2003 | Journal of Clinical Gastroenterology2003，，1： | 1 |
| 9 | TheBrand Loyalty Life Cycle: Implications for Marketers 显示文摘 | Bennett Rebekah Sharyn Rundle- Thiele | 2005 | Journal of Brand Management2005，12，4： | 1 |
| 10 | Clinical Pharmaeokinetics of unbound docetaxel: Role of Polysorbate 80 and Serum Proteins显示文摘 | Waiter J Loos Sharyn D Baker Jaap Verweij MD | 2003 | Clinical Pharmacology & Therapeutics2003，74，： | 1 |
| 11 | The incidence and significance of accidental hypothermia in major trauma-a prospective observational study显示文摘 | Sharyn I Ruth E Peter C | 2011 | Resuscitation2011，82，3： | 1 |
| 12 | Cerebellar Hemorrhage in Extremely Low Birth Weight Infants:Incidence,Risk Factors,and Impact on Long-Term Outcomes显示文摘 | Patricia M Sharyn G | 2008 | Neonatal Network2008，27，6： | 1 |
| 13 | Efficacy and safety of sucrose for procedural pain relief in preterm and term neonates显示文摘 | Sharyn Gibbins Bonnie Stevens Ellen Hodnett | 2002 | Nurs res2002，51，6： | 1 |
| 14 | Phase Ⅰ and pharmacokinetic study of GI147211,a water-soluble camptothecin analogue,administered for five consecutive days every three weeks显示文摘 | Eckhardt SG Sharyn DB John RE | 1998 | Clinical Cancer Research1998，4，： | 1 |
| 15 | The practice and employee satisfaction relationship: employees 显示文摘 | Huang Yu-Ting Rundle-Thiele Sharyn | 2014 | Tourism Management2014，，42： | 1 |
| 16 | Understanding of thought bubbles as mental representations in children with autism:implications for theory of mind显示文摘 | Sharyn K Kevin D | 2004 | J Autism Dev Disord2004，34，6： | 1 |
| 17 | Organizational rationality ,performance ,and social responsibility :result from the hospital industry显示文摘 | Edmund R Becket Sharyn J Potter | 2002 | Journal of Health Care Finance2002，29，1： | 1 |
| 18 | Evaluating RFID middleware 显示文摘 | Sharyn Leaver | 2004 | Forrester Research2004，8，： | 1 |
| 19 | Safety profile of sustained-release bupropion in depression:Results of three clinical trials显示文摘 | Edmund C Stephen M Sharyn R | 1999 | Clin Ther1999，21，3： | 1 |
| 20 | Evaluating RFID middleware 显示文摘 | Sharyn Leaver | 2004 | Forrester Research2004，8，： | 1 |
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