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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Catalytic combustion of methane over palladium-based catalysts 显示文摘 | Ciuparu D Maxim R L Altman E | 2002 | Catalysis Review2002，44，： | 1 |
| 3 | Wavelets and functional magnetic resonance imaging of the human brain显示文摘 | Fadili J Maxim V | 2004 | NeuroImage2004，23，1： | 1 |
| 4 | Workplace monitoring of occupational exposure to refractory ceramic fiber-a 17-year , retrospective显示文摘 | MAXIM L D ALLSHOUSE J FAIRFAX R E | 2008 | Inhal Toxicol2008，20，3： | 1 |
| 5 | From Vegetable Oils to Polyurethanes:Synthetic Routes to Polyols and Main Industrial Products显示文摘 | Myriam D Maxime E Remi A | 2012 | Polymer Rev2012，52，： | 1 |
| 6 | Stackelberg versus Cournot oligopoly equilibrium 显示文摘 | ANDERSON S P MAXIM E | 1992 | International Journal of Industrial Organization1992，10，1： | 1 |
| 7 | Genotyping Single Nucleotide Polymorphisms for Selection of Barley β-amylase Alleles显示文摘 | Maxime P Michael G K J Jason K E | 2002 | Plant Molecular Biology Reporter2002，20，： | 1 |
| 8 | Wavelets and functional magnetic resonance imaging of the human brain显示文摘 | Bullmore E Fadili J Maxim V | 2004 | NeuroImage2004，23，1： | 1 |
| 9 | Hydration and health promotion: a brief introduction 显示文摘 | MAXIME E B | 2007 | Am J Coil Nutr2007，26，： | 1 |
| 10 | Wavelets and functional magnetic resonance imaging of the human brain显示文摘 | Bullmore E Fadili J Maxim V | 2004 | NeuroImage2004，23，1： | 1 |
| 11 | Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer显示文摘 | Yixin Wang Jan GM Klijn Yi Zhang Anieta M Sieuwerts Maxime P Look Fei Yang Dmitri Talantov Mieke Timmermans Marion E Meijer-van Gelder Jack Yu Tim Jatkoe Els MJJ Berns David Atkins John A Foekens | 2005 | The Lancet2005，，9460： | 1 |
| 12 | Effect of heating on the distribution of transforming growth factor- 132 in bovine milk 显示文摘 | Abderrazak A Adil R Maxime S E L | 2011 | Food Research International2011，44，： | 1 |
| 13 | Wavelets and functional magnetic resonance imaging of the human brain 显示文摘 | Bullmore E Fadili J Maxim V | 2004 | NcuroImage2004，23，1： | 1 |
| 14 | Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-α显示文摘 | NADIA E MAXIME T MATT HAY MA | 2003 | Am J Respir Crit Care Med2003，168，9： | 1 |
| 15 | A new method for the synthesis of the marine alkaloid fascaplysin based on the microwave-assisted Minisci reaction显示文摘 | Maxim E Z Vladimir A K | 2013 | Tetrahedron Lett2013，54，： | 1 |
| 16 | Wavelets and functioaalmagnetic resonance imaging of the human brain 显示文摘 | Bullmore E Fadili J Maxim V | 2004 | Neurolmage2004，23，1： | 1 |
| 17 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 18 | From vegetable oils to polyurethanes: Synthetic routes to polyols and main industrial products 显示文摘 | Desroches Myriam E Maxime A | 2012 | Polymer Reviews2012，52，1： | 1 |
| 19 | EQUALIZER: A Scalable Parallel Rendering Framework 显示文摘 | STEFAN E MAXIM M RENATO P | 2009 | IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS2009，15，3： | 1 |
| 20 | Wavelets and functional magnetic resonance imaging of the human brain 显示文摘 | Bullmore E Fadili J Maxim V | 2004 | NeuroImage2004，23，1： | 1 |
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