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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 4 | LAVES PHASE ALLOYS FOR HIGH TEMPERATURE APPLICATIONS显示文摘Ternary Laves phases with transition metals and aluminium were overviewed with respect to their use for structural high temperature applications. The relation between constitution, phase stability, crystal structure and basic mechanical properties was discussed. The crystal structure-hexagonal C14 structure or cubic C15 structure-is a function of atomic radii and valence electron concentration. A strong positive correlation of basic mechanical properties-hardness, yield stress-with the sublimation energy of the phases was found. The brittle to ductile transition temperature was observed at about 60% of the melting temperature. The regarded ternary Laves phases allow alloying to form stable equilibria with the less hard and brittle B2 aluminides. Advantageous examples are alloys of type NbNiAl NiAl, TaNiAl NiAl, and TaFeAl FeAl. Multiphase NiAl Ta Cr alloys are regarded as promising for structural high temperature applications and have been selected for a materials development which aims at applications in gas turbines at temperatures above those of Ni base superalloys, such alloy can be prepared by ingot metallurgy and powder metallurgy and hot forming is possible. Characteristic data were presented with respect to mechanical behaviour. The alloys showed a high thermoshock resistance in spite of the comparatively high brittle to ductile transition temperature. The prospects of alloy development were discussed. | G.Sauthoff Max Planck Institut für Eisenforschung Gmbh., D 40074 Düsseldorf, Germany | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 2 |
| 5 | 瑞典沿海生境生态系统的物产与服务:生态系统变迁的鉴别、评估和意义显示文摘人口高密度和经济快速发展使沿海地区处于多种威胁之中。这种状况如何影响人类福利及人类对生态系统物产与服务的依赖呢?本文首次对温带地区沿海主要生境(大型海藻、海草、翡翠贻贝床和无植被软海底)的生态系统物产与服务状况进行了评估。作者将40多种物产和服务细分为供给服务、调节服务和文化服务。作者列举了各类中瑞典境内各种生态系统服务的实例,包括经济价值和不同生境相对重要性评估。例如,具有极大重要性的翡翠贻贝对缓解富营养化的作用、沙质海滩的休闲娱乐功能、海草和大型藻类对渔产、波浪能和海流能的作用。本文评估了3种沿海生态系统变化对生态系统物产与服务的影响:1)海草床变为无植被海底;2)无植被浅水软海底向丝状藻类基质转变;3)坚硬基质上大型藻类向贻贝的转变。文章结尾部分对生物多样性评估、生态系统的普遍联系性和潜在经济价值等从管理角度进行了讨论。 | Patrik Rnnbck Nils Kautsky Leif Pihl Max Troell Tore Sderqvist Hkan Wennhage 梁虹 | 2007 | AMBIO-人类环境杂志2007，36，B11： | 2 |
| 6 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 7 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 8 | Computer aided design fluid power systems显示文摘 | MAX D DON R | 1982 | Proceeding of the National Conference on Power Transnission Volume 1x 9th Annual Meeting1982，9，1： | 1 |
| 9 | Evidence-based medicine in the therapy of the acute respiratory distress syndrome 显示文摘 | Kopp R Kuhlen R Max M | 2002 | Intens Care Med2002，28，3： | 1 |
| 10 | Effects of the land application of sewage sludge on soil heavy metal concentrations and soil microbial communities 显示文摘 | Kelly J J Haggblom Max Tate R L | 1999 | Soil Biol Biochem1999，31，10： | 1 |
| 11 | Controlled growth of a molecular bulk heterojunction photovoltaic cell显示文摘 | Yang F Max S Stephen R | 2005 | Nature Materials2005，，4： | 1 |
| 12 | 3D analysis of bottom hole assembly under large defleetion显示文摘 | L1 Z F MAX R HUANG W H | 1996 | SPE Drilling & Completion1996，11，2： | 1 |
| 13 | Size-controlled Hydroxyapatite Nanoparticles as Self-organize Organic-inorganic Composite Materials显示文摘 | Viorel M R Chuen H N Max W | 2005 | Biomaterials2005，26，26： | 1 |
| 14 | Effects of nitrogen on grown-in oxygen precipitates in large diameter Czochralski silicon 显示文摘 | YU X G YANG D R YANG J S MAX Y LI L B QUE D L | 2003 | Chin J Semicond2003，24，1： | 1 |
| 15 | Ocular changes during pregnancy 显示文摘 | Mackensen F Paulus WE Max R | 2014 | Dtsch Arztebl Int2014，34，： | 1 |
| 16 | Magnetic ionexchange resin treatment: Impact of water type and resin use 显示文摘 | Max R D Mergen Bruce Jefferson Simon A | 2008 | Water Research2008，42，89： | 1 |
| 17 | Evidence based medicine in the therapy of the acute respiratory distress syndrome 显示文摘 | Kopp R Kuhlen R Max M | 2006 | Intens Care Med2006，28，3： | 1 |
| 18 | Project Management Institute显示文摘 | R Max Wideman | 1992 | Project and Program Risk Management1992，，3： | 1 |
| 19 | Effect of ultrasound on the structural and physiochemical properties of organosolv soluble hemicelluloses from wheat straw显示文摘 | SUN R C SUN X F MAX H | 2002 | Ultrason Sonochem2002，9，2： | 1 |
| 20 | Quantitative real-time RT-PCR for detection of disseminated tumor cells in peripheral blood of patients with colorectal cancer using different mRNA markers显示文摘 | Schuster R Max N Mann B | | 0，，02： | 1 |
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