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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Surface acidity of pyrophyllite and talc 显示文摘 | Wu D Y Matue N Henmi T | 1992 | Clay Sci1992，8，6： | 2 |
| 3 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 4 | 星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，6： | 2 |
| 5 | Health damages from air pollution in China 显示文摘 | Matus K Nam K-M Selin N E | 2012 | Global environmentalchange2012，22，1： | 1 |
| 6 | Evaluation of a Bench- Top HIV Ultra-Deep Pyrosequencing Drug-Resistance Assay in the Clinical Laboratory 显示文摘 | Avidor B Girshengorn S Matus N | 2013 | J Clin Mierobiol2013，51，3： | 1 |
| 7 | In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women 显示文摘 | Matu M N Orinda G O Njagi E N | 2010 | Anaerobe2010，16，3： | 1 |
| 8 | Health damages from air pollution in China显示文摘 | Matus K Namb K Selin N E | 2012 | Global Environ Chang2012，，22： | 1 |
| 9 | Theoretical study of the hydrogen release from ammonia alane and thecatalytic effect of alane 显示文摘 | NGUYEN V S MATUS M H NGAN V N | 2008 | J Phys Chem C2008，112，： | 1 |
| 10 | Isolation of WDR and bHLH genes relatedto avonoid synthesis in grapevine显示文摘 | MATUS J T POUPIN M J CAN魻N P BORDEU E ALCALDE JA ARCE-JOHNSON P | 2010 | Plant Molecular Biology2010，72，11： | 1 |
| 11 | 通过星形胶质细胞转录组分析寻找脑卒中治疗靶标显示文摘星形胶质细胞支持正常的脑功能,但当它们在卒中等病理条件下变得具有反应性时也可能促成神经退行性病变。然而,反应性星形胶质细胞增生的有益和有害特性之间依赖于背景的相互作用的分子基础仍然未被完全理解。我们使用RiboTag技术,在短暂性大脑中动脉闭塞(tMCAO)72 h后的小鼠星形胶质细胞中特异性地纯化翻译m RNA,从而产生卒中特异性星形胶质细胞翻译组数据库。与对照组大脑相比,t MCAO后的反应性星形胶质细胞显示与A2表型相关的转录物富集,这与神经保护相关。我们还发现,星形胶质细胞也会上调大量潜在的神经毒性基因。本研究共鉴定了1,003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1是最显著的。为了进一步探索Stat3介导的途径对卒中发病机制的影响,我们对星形胶质细胞特异性条件性缺失Stat3的小鼠进行tMCAO处理,发现局灶性缺血72 h后的小鼠脑梗死体积减小,运动功能改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,支持星形胶质细胞在生理和病理条件下均对脑功能提供了关键保障作用的观点。 | Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 | 2019 | 神经损伤与功能重建2019，14，2： | 1 |
| 12 | Health damages from air pollution in China显示文摘 | Matus K Nam K M Selin N E | 2012 | Global Environmental Change2012，，1： | 1 |
| 13 | Thermal stability of glued wood joints measured by shear tests显示文摘 | Sebastian C Matus J Peter N | 2011 | European Journal of Wood and Wood Products2011，69，1： | 1 |
| 14 | Neural network based tire/road friction force estimation 显示文摘 | Matu~ko J Petroi6 I Peri6 N | 2008 | Engineering Applications of Artificial Intelligence2008，21，3： | 1 |
| 15 | Wheat genotypic variability in grain yield and carbon isotope discrimination under Mediterranean conditions assessed by spectral reflectance显示文摘A collection of 368 advanced lines and cultivars of spring wheat(Triticum aestivum L.) from Chile, Uruguay, and CIMMYT(Centro Internacional de Mejoramiento de Maíz y Trigo), with good agronomic characteristics were evaluated under the Mediterranean conditions of central Chile. Three different water regimes were assayed: severe water stress(SWS, rain fed), mild water stress(MWS; one irrigation around booting), and full irrigation(FI; four irrigations: at tillering,flag leaf appearance, heading, and middle grain filling). Traits evaluated were grain yield(GY), agronomical yield components,days from sowing to heading, carbon isotope discrimination(D13C) in kernels, and canopy spectral reflectance. Correlation analyses were performed for 70 spectral reflectance indices(SRI) and the other traits evaluated in the three trials. GY and D13C were the traits best correlated with SRI, particularly when these indices were measured during grain filling. However,only GY could be predicted using a single regression, with ResearchNormalized Difference Moisture Index(NDMI2: 2,200; 1,100)having the best fit to the data for the three trials. For D13C, only individual regressions could be forecast under FI(r2: 0.25–0.37)and MWS(r2: 0.45–0.59) but not under SWS(r2: 0.03–0.09).NIR‐based SRI proved to be better predictors than those that combine visible and NIR wavelengths. | Gustavo A. Lobos Iván Matus Alejandra Rodriguez Sebastián Romero-Bravo José Luis Araus Alejandro del Pozo | 2014 | Journal of Integrative Plant Biology2014，56，5： | 1 |
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