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| 1 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 2 | Analysis of the grape MYBR2R3 subfamily reveals expanded wine quality-related clades and con-served gene structure organization across Vitis and Arabidopsis genomes显示文摘 | MATUS J T AQUEA M ARCE-JOHNSON P | 2008 | BMC Plant Biology2008，，： | 1 |
| 3 | Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A | 2009 | J Exp Bot2009，60，3： | 1 |
| 4 | Separation and identification of carotenoids from different coloured paprika by reversed-phase high-performance liquid chromatography显示文摘 | Deli J Matus Z Molnár P Tóth G | 2001 | Eur Food Res Technol2001，213，： | 1 |
| 5 | 2011, The grapevine guard cell-related VvMYB60 transcription factor is in- volved in the regulation of stomatal activity and is dif- ferentially expressed in response to ABA and osmotic stress显示文摘 | Galbiati M Matus J T Francia P | 2011 | BMC Plant Biology2011，11，： | 1 |
| 6 | Analysis of the grape MYB R2R3 subfamily reveals expanded wine qua|ity-related clades and conserved gene structure organization across Vitis and Arabidopsis gennmes显示文摘 | Matus J T Aquea F Arce-Johnson P | 2008 | BMC Plant Biol2008，8，： | 1 |
| 7 | Post-version sunlight exposure induces MYB-mediated ranseriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A | 2009 | Journal of Experimental Botany2009，60，3： | 1 |
| 8 | Carotenoid composition in the fruits of Asparagus officinalis显示文摘 | Deli J Matus Z Tóth G | 2000 | Journal of Agricultural and Food Chemistry2000，48，7： | 1 |
| 9 | Post-veraison sunlight exposure induces MYB- mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera显示文摘 | Matus J T Loyola R Vega A Pefianeira A Bordeu E Arcejohnson p | 2009 | Journal of Experimental Botany2009，60，3： | 1 |
| 10 | Analysis of the grape MYB R2R3 subfamily reveals expanded wine quality-related clades and conserved gene structure organization across Vitis and Ara- bidopsis genomes显示文摘 | MATUS J T AQUEA F ARCEJOHNSON P | 2008 | BMC Plant Biology2008，8，： | 1 |
| 11 | Identification and characterization of a novel N homologue in tobacco plants显示文摘 | Stange C Matus J T Elorza A | 2004 | Function Plant Biology2004，37，： | 1 |
| 12 | Isolation of WDR and bHLH genes relatedto avonoid synthesis in grapevine显示文摘 | MATUS J T POUPIN M J CAN魻N P BORDEU E ALCALDE JA ARCE-JOHNSON P | 2010 | Plant Molecular Biology2010，72，11： | 1 |
| 13 | Changes in the sensitivity of parasitic weed seeds to germination stimulants 显示文摘 | Matu? ova R Van Mourik T Bouwmeester H J | 2004 | Seed Science Research2004，14，4： | 1 |
| 14 | Carotenoid composition in the fruits of Asparagus officinalis显示文摘 | De li J Matus Z Tóth G | 2000 | Journal of Agricultural and Food Chemistry2000，48，7： | 1 |
| 15 | Analysis of the grape MYB R2R3 subfamily reveals expanded wine quality-related clades and conserved gene structure organization across Vitis and Arabidopsis genomes显示文摘 | MATUS J T AQUEA F ARCE-JOHNSON P | 2008 | BMC Plant Biology2008，8，： | 1 |
| 16 | Identification and characterization of a novel tobacco mosaic virus resistance N gene homologous in Nicotiana tabacum plants 显示文摘 | Stange C Matus J T Elorza A | 2004 | Funct Plant Biol2004，31，2： | 1 |
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