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| 1 | Management of hepatocellular carcinoma with portal vein thrombosis显示文摘Management of hepatocellular carcinoma(HCC) with portal vein thrombosis(PVT) is complex andrequires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contraindicated, and surgical resection is only rarely performed in select centers. Systemic medical therapy with sorafenib has been shown to modestly prolong survival. Transarterial chemoembolization has been performed in select cases but has shown a high incidence of complications. Emerging data on treatment of PVT with Y-90 radioembolization suggest that this modality is well-tolerated and associated with favorable overall survival. Current society guidelines do not yet specifically recommend radioembolization for patients with PVT, but this may change with the development of newer staging systems and treatment algorithms. In this comprehensive literature review, we present current and available management options with the relative advantages, disadvantages and contraindications of these treatment options with summarized data on overall survival. | Matthew Quirk Yun Hwan Kim Sammy Saab Edward Wolfgang Lee | 2015 | World Journal of Gastroenterology2015，21，12： | 12 |
| 2 | 青藏高原上发现世界最老的岩面艺术显示文摘青藏高原高寒、缺氧,属于地球上居住条件极端恶劣的环境.人类在什么时候克服生理和生存的重重困难去征服高原是人类演化历史中至关重要的科学问题.在第二次青藏高原综合科学考察过程中,研究团队在西藏邱桑温泉附近发现了一组由古人类有意留下的手印和脚印(简称手脚印).通过对这些手脚印进行详细的3D扫描,解剖学和沉积学分析,以及铀系法测年,发现这些手脚印是由古人类在泉华软泥上用其手脚压制而成,随后这些留有印记的软泥迅速脱水并固结成岩,得以长期保留.这些手脚印形成于距今16.9~22.6万年,是人类占据高原已知最早的记录.由于这些有意压制的手脚印排列有序并富于创造性,研究团队认为这是世界上最古老的岩面艺术,其中的手印也是世界上目前已知最古老有意创作的手印.该研究显示邱桑古人类比智人走出非洲的时间更早,但与最近在青藏高原边缘发现的丹尼索瓦人的年代相近.手脚印的创作者究底是丹尼索瓦人还是其他直立人?这给考古学家们留下了新的挑战. | 章典 Matthew R.Bennett 程海 王蕾彬 张海伟 Sally C.Reynolds 张盛达 王晓晴 李腾 Tommy Urban 裴卿 吴志峰 张普 刘春茹 汪亚峰 王聪 张冬菊 R.Lawrence Edwards | 2021 | Science Bulletin2021，66，24： | 7 |
| 3 | 基于嫦娥一号卫星微波辐射计数据的月球Cabeus撞击坑水冰含量研究显示文摘月球极地水冰存在与否、存在形式和存在数量等科学问题,是当前月球科学研究的重要目标之一.2009年10月9日,美国半人马座火箭和卫星相继撞击月球南极Cabeus撞击坑,证实了月球极地水冰的存在,但对其含量、分布范围等的研究还有争议.极地水冰的存在会改变极地月壤的介电常数,而微波辐射计是获取介质介电常数的最有效的工具.因此,根据37GHz频率条件下的月壤被动微波辐射传输数值模拟结果,改进月壤辐射传输模型.对比分析了Odelevsky模型、Wagner和Landau-Lifshitz模型、Clausius模型等8个常用的混合介电常数计算模型,表明Lichtenecker模型与改进的Dobson模型得到的介电常数值相差最大,折射模型得到的结果偏大,Odelevsky模型、强起伏定理与Wagner和Landau-Lifshitz模型、Clausius模型、Bruggeman-Hanai模型得到的结果非常接近.基于Odelevsky模型和改进的月壤辐射传输模拟,建立了月壤体积含冰量与微波辐射亮温的关系.并根据嫦娥一号卫星获取的相应的微波辐射计数据,进行了Cabeus撞击坑水冰含量反演研究.结果表明,改进的辐射传输模型适用于高频条件下的一层月壤辐射传输模拟;月球南极Cabeus撞击坑地区月壤微波辐射亮温为69.93K(37GHz),相应的体积含冰量约为2.8%. | 孟治国 陈圣波 Edward Matthew Osei Jnr 汪自军 崔腾飞 | 2010 | 中国科学:物理学、力学、天文学2010，40，11： | 5 |
| 4 | Research on water ice content in Cabeus crater using the data from the microwave radiometer onboard Chang’e-1 satellite显示文摘The existence, formation and content of water ice in the lunar permanently shaded region is one of the important questions for the current Moon study. On October 9, 2009, the LCROSS mission spacecraft impacted the Moon, and the initial result verified the existence of water on the Moon. But the study on formation and content of water ice is still under debate. The existence of water ice can change the dielectric constants of the lunar regolith, and a microwave radiometer is most sensitive to the dielectric parameters. Based on this, in this paper, the radiation transfer model is improved according to the simulation results in high frequency. Then the mixture dielectric constant models, including Odelevsky model, Wagner and landau-Lifshitz model, Clau-sius model, Gruggeman-Hanai model, etc., are analyzed and compared. The analyzing results indicate that the biggest difference occurs between Lichtenecker model and the improved Dobson model. The values estimated by refractive model are the second biggest in all the models. And the results from Odelevsky model, strong fluctuation model, Wagner and Landau –Lifshitz model, Clausius model and Bruggeman-Hanai model are very near to each other. Thereafter, the relation between volume water ice content and microwave brightness temperature is constructed with Odelevsky mixing dielectric model and the improved radiative transfer simulation, and the volume water ice content in Cabeus crater is retrieved with the data from microwave radiometer onboard Chang’e-1 satellite. The results present that the improved radiative transfer model is proper for the brightness temperature simulation of the one infinite regolith layer in high frequency. The brightness temperature in Cabeus crater is 69.93 K (37 GHz), and the corresponding volume water ice content is about 2.8%. | MENG ZhiGuo 1 , CHEN ShengBo 1* , Edward Matthew OSEI Jnr 2 , WANG ZiJun 1 & CUI TengFei 1 1 College of Geoexploration Science and Technology, Jilin University, Changchun 130026, China 2 Department of Geomatic Engineering, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 5 | Influence of Temperature and Frequency on Microwave Dielectric Properties of Lunar Regolith Simulant显示文摘The dielectric constant of the lunar regolith can directly influence the reflection coefficient and the trans-mission coefficient of the Moon′s surface, and plays an important role in the Moon research. In order to study the di-electric properties of the lunar regolith, the lunar regolith simulant was made according to the making procedure of the CAS-1 simulant made by Chinese Academy of Sciences. Then the dielectric constants of the lunar regolith simulant were measured with 85070E Aiglent Microwave Network Analyzer in the frequency ranging from 0.2 GHz to 20.0 GHz and at temperature of 25.1℃, 17.7℃, 13.1℃, 11.5℃, 9.6℃, 8.0℃, 4.1℃, -0.3℃, -4.7℃, -9.5℃, -18.7℃, -27.7℃, and -32.6℃, respectively. The Odelevsky model was employed to remove the influence of water in the air on the final effective dielectric constants. The results indicate that frequency and temperature have apparent influences on the dielectric constants of the lunar regolith simulant. The real parts of the dielectric constants increase fast over the range of 0.2 GHz to 3.0 GHz, but decrease slowly over the range of 4.0 GHz to 20.0 GHz. The opposite phenomenon occurs in the imaginary parts. The influences of the frequency and temperature on the brightness temperature were also estimated based on the radiative transfer equation. The result shows that the variation of the frequency and temperature results in great changes of the microwave brightness temperature emitting from the lunar regolith. | MENG Zhiguo CHEN Shengbo DU Xiaojuan EDWARD Matthew Osei Jnr LU Peng WANG Zijun | 2011 | Chinese Geographical Science2011，21，1： | 3 |
| 6 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
| 7 | GD2+ cancer stem cells in triple-negative breast cancer:mechanisms of resistance to breast cancer therapies显示文摘Research has led to the development of tailored treatment options for different cancers in different patients.Despite some treatments being able to provide remarkable responses,nearly all current treatments encounter the same issue:resistance.Here,we discuss our experiences with how breast cancers resist therapies.The focus of our discussion revolves around the cancer stem cell subpopulation and their mechanisms for resistance. | Khoa Nguyen Emily McConnell Orielle Edwards Bridgette M.Collins-Burow Matthew E.Burow | 2022 | Cancer Drug Resistance2022，5，3： | 2 |
| 8 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani MD Sung W. Cho MD Christos Colovos MD PhD Songwon Seo MS Jan Franko MD PhD Scott D. Richard MD Robert P. Edwards MD Charles K. Brown MD PhD Matthew P. Holtzman MD Herbert J. Zeh MD David L. Bartlett MD | 2008 | Annals of Surgical Oncology2008，，3： | 2 |
| 9 | Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study显示文摘 | Matthew M. Cheung Edward S. Hui Kevin C. Chan Joseph A. Helpern Liqun Qi Ed X. Wu | 2008 | Neuroimage2008，，2： | 2 |
| 10 | National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary显示文摘 | Terry A. Jacobson Matthew K. Ito Kevin C. Maki Carl E. Orringer Harold E. Bays Peter H. Jones James M. McKenney Scott M. Grundy Edward A. Gill Robert A. Wild Don P. Wilson W. Virgil Brown | 2014 | Journal of Clinical Lipidology2014，，： | 2 |
| 11 | Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fibrillation: Success and limitations显示文摘 | David D. Spragg Irfan Khurram Stefan L. Zimmerman Hirad Yarmohammadi Bernie Barcelon Matthew Needleman David Edwards Joseph E. Marine Hugh Calkins Saman Nazarian | 2012 | Heart Rhythm2012，，12： | 2 |
| 12 | The greenness of city 显示文摘 | EDWARD L G MATTHEW K | 2008 | Rappa- port Institute Taubman Center Policy Briefs2008，，3： | 1 |
| 13 | Dynamics and Phylogenetic Implications of MtDNA Control Region Sequences in New World Jays (Aves: Corvidae)显示文摘 | Matthew A. Saunders Scott V. Edwards | 2000 | Journal of Molecular Evolution2000，，2： | 1 |
| 14 | Re-placement of mitral valve posterior chordae tendineae with expanded polytetrafluoroethylene suture显示文摘 | Karyn Kunzelman Matthew S Reimink Edward D Verrier | 1996 | J Card Surg1996，11，： | 1 |
| 15 | Aggressive Surgical Management of Peritoneal Carcinomatosis With Low Mortality in a High-Volume Tertiary Cancer Center显示文摘 | Niraj J. Gusani Sung W. Cho Christos Colovos Songwon Seo Jan Franko Scott D. Richard Robert P. Edwards Charles K. Brown Matthew P. Holtzman Herbert J. Zeh David L. Bartlett | 2008 | Annals of Surgical Oncology2008，，3： | 1 |
| 16 | Prevalence of renovascular disease in the elderly: A population-based study显示文摘 | Kimberley J. Hansen Matthew S. Edwards Timothy E. Craven Gregory S. Cherr Sharon A. Jackson Richard G. Appel Gregory L. Burke Richard H. Dean | 2002 | Journal of Vascular Surgery2002，，3： | 1 |
| 17 | Identification of phases in zinc alloy powders using electron backscatter diffraction显示文摘 | Martin G Perez Edward A Kenik Matthew J O'Keefe F Scott Miller Benedict Johnson | 2006 | Mater Sci Eng A2006，424，： | 1 |
| 18 | The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy显示文摘 | Sandra L. Wong MD Michael J. Edwards MD Celia Chao MD Todd M. Tuttle MD R. Dirk Noyes MD David J. Carlson MD Alison L. Laidley MD Terre Q. McGlothin MD Philip B. Ley MD C. Matthew Brown MD Rebecca L. Glaser MD Robert E. Pennington MD Peter S. Turk MD Dian | 2002 | Annals of Surgical Oncology2002，，3： | 1 |
| 19 | THE COMPLEMENTARITY BETWEEN CITIES AND SKILLS*显示文摘 | Edward L.Glaeser Matthew G.Resseger | 2010 | Journal of Regional Science2010，，1： | 1 |
| 20 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
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