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| 1 | Acute mesenteric ischemia after cardio-pulmonary bypass surgery显示文摘Acute mesenteric ischemia (AMI) is a highly-lethal surgical emergency. Several pathophysiologic events (arterial obstruction, venous thrombosis and diffuse vasospasm) lead to a sudden decrease in mesenteric blood flow. Ischemia/reperfusion syndrome of the intestine is responsible for systemic abnormalities, leading to multi-organ failure and death. Early diagnosis is difficult because the clinical presentation is subtle, and the biological and radiological diagnostic tools lack sensitivity and specificity. Therapeutic options vary from conservative resuscitation, medical treatment, endovascular techniques and surgical resection and revascularization. A high index of suspicion is required for diagnosis, and prompt treatment is the only hope of reducing the mortality rate. Studies are in progress to provide more accurate diagnostic tools for early diagnosis. AMI can complicate the post-operative course of patients following cardio-pulmonary bypass (CPB). Several factors contribute to the systemic hypo-perfusion state, which is the most frequent pathophysiologic event. In this particular setting, the clinical presentation of AMI can be misleading, while the laboratory and radiological diagnostic tests often produce inconclusive results. The management strategies are controversial, but early treatment is critical for saving lives. Based on the experience of our team, we consider prompt exploratory laparotomy, irrespective of the results of the diagnostic tests, isthe only way to provide objective assessment and adequate treatment, leading to dramatic reduction in the mortality rate. | Bassam Abboud Ronald Daher Joe Boujaoude | 2008 | World Journal of Gastroenterology2008，14，35： | 9 |
| 2 | Consequences of dysthyroidism on the digestive tract and viscera显示文摘Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and def iciency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo-and hyperthyroidism. Specifi c digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to conf irm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations. | Ronald Daher Thierry Yazbeck Joe Bou Jaoude Bassam Abboud | 2009 | World Journal of Gastroenterology2009，15，23： | 9 |
| 3 | Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions显示文摘Obesity is a global health epidemic with considerable economic burden.Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk.Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease(GERD)has been a topic of debate.GERD,including erosive esophagitis,is highly prevalent in the obese population.The role of pre-operative endoscopy in bariatric surgery has been controversial.Two schools of thought exist on the matter,one that believes routine upper endoscopy before bariatric surgery is not warranted in the absence of symptoms and another that believes that symptoms are poor predictors of underlying esophageal pathology.This debate is particularly important considering the evidence for the association of laparoscopic sleeve gastrectomy(LSG)with de novo and/or worsening GERD compared to the less popular Roux-en-Y gastric bypass procedure.In this paper,we try to address 3 burning questions regarding the inter-relationship of obesity,GERD,and LSG:(1)What is the prevalence of GERD and erosive esophagitis in obese patients considered for bariatric surgery?(2)Is it necessary to perform an upper endoscopy in obese patients considered for bariatric surgery?And(3)What are the long-term effects of sleeve gastrectomy on GERD and should LSG be done in patients with pre-existing GERD? | Halim Bou Daher Ala I Sharara | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 4 | New trends in colorectal surgery: Single port and natural orifice techniques显示文摘Single-incision laparoscopic surgery(SILS)and natural orifice transluminal endoscopic surgery(NOTES)have rapidly gained pace worldwide,potentially replacing conventional laparoscopic surgery(CLS)as the preferred colorectal surgery technique.Currently available data mainly consist of retrospective series analyzed in four meta-analyses.Despite conflicting results and lack of an objective comparison,SILS appears to offer cosmetic advantages over CLS.However,due to conflicting results and marked heterogeneity,present data fail to show significant differences in terms of operative time,postoperative morbidity profiles,portsite complications rates,oncological appropriateness,duration of hospitalization or cost when comparing SILS with conventional laparoscopy for colorectal procedures.The application of'pure'NOTES in humans remains limited to case reports because of unresolved issues concerning the ideal access site,distantorgan reach,spatial orientation and viscera closure.Alternatively,minilaparoscopy-assisted natural orifice surgery techniques are being developed.The transanal'down-to-up'total mesorectum excision has been derived for transanal endoscopic microsurgery(TEM)and represents the most encouraging NOTES-derived technique.Preliminary experiences demonstrate good oncological and functional short-term outcomes.Largescale randomized controlled trials are now mandatory to confirm the long-term SILS results and validate transanal TEM for the application of NOTES in humans. | Ronald Daher Elie Chouillard Yves Panis | 2014 | World Journal of Gastroenterology2014，20，48： | 4 |
| 5 | Apical hypertrophic cardiomyopathy显示文摘We describe a patient with asymptomatic apical hypertrophic cardiomyopathy(AHCM)who later developed cardiac arrhythmias,and briefly discuss the diagnostic modalities,differential diagnosis and treatment option for this condition.AHCM is a rare form of hypertrophic cardiomyopathy which classically involves the apex of the left ventricle.AHCM can be an incidental finding,or patients may present with chest pain,palpitations,dyspnea,syncope,atrial fibrillation,myocardial infarction,embolic events,ventricular fibrillation and congestive heart failure.AHCM is frequently sporadic,but autosomal dominant inheritance has been reported in few families.The most frequent and classic electrocardiogram findings are giant negative T-waves in the precordial leads which are found in the majority of the patients followed by left ventricular(LV)hypertrophy.A transthoracic echocardiogram is the initial diagnostic tool in the evaluation of ACHM and shows hypertrophy of the LV apex.AHCM may mimic other conditions such as LV apical cardiac tumors,LV apical thrombus,isolated ventricular non-compaction,endomyocardial fibrosis and coronary artery disease.Other modalities,including left ventriculography,multislice spiral computed tomography,and cardiac magnetic resonance imagings are also valuable tools and are frequently used to differentiate AHCH from other conditions.Medications used to treat symptomatic patients with AHCM include verapamil,beta-blockers and antiarrhythmic agents such as amiodarone and procainamide.An implantable cardioverter defibrillator is recommended for high risk patients. | Syed Wamique Yusuf Jaya D Bathina Jose Banchs Elie N Mouhayar Iyad N Daher | 2011 | World Journal of Cardiology2011，3，7： | 4 |
| 6 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 7 | Digestive manifestations of parathyroid disorders显示文摘The parathyroid glands are the main regulator of plasma calcium and have a direct influence on the digestive tract.Parathyroid disturbances often result in unknown long-standing symptoms.The main manifestation of hypoparathyroidism is steatorrhea due to a deficit in exocrine pancreas secretion.The association with celiac sprue may contribute to malabsorption.Hyperparathyroidism causes smooth-muscle atony,with upper and lower gastrointestinal symptoms such as nausea,heartburn and constipation.Hyperparathyroidism and peptic ulcer were strongly linked before the advent of proton pump inhibitors.Nowadays,this association remains likely only in the particular context of multiple endocrine neoplasia type 1/Zollinger-Ellison syndrome.In contrast to chronic pancreatitis,acute pancreatitis due to primary hyperparathyroidism is one of the most studied topics.The causative effect of high calcium level is confirmed and the distinction from secondary hyperparathyroidism is mandatory.The digestive manifestations of parathyroid malfunction are often overlooked and serum calcium level must be included in the routine workup for abdominal symptoms. | Bassam Abboud Ronald Daher Joe Boujaoude | 2011 | World Journal of Gastroenterology2011，17，36： | 2 |
| 8 | Particulate matter (PM) concentrations in underground and ground-level rail systems of the Los Angeles Metro显示文摘 | Winnie Kam Kalam Cheung Nancy Daher Constantinos Sioutas | 2010 | Atmospheric Environment2010，，8： | 2 |
| 9 | Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion显示文摘 | évelyn Traina Silvia Daher Antonio Fernandes Moron Sue Yazaki Sun Camila Sommerauer Franchim Rosiane Mattar | 2010 | Journal of Reproductive Immunology2010，，： | 2 |
| 10 | Boundedness and global stability for a predator-prey model with modified Leslie-Gower and Holling-type II schemes显示文摘 | M.A. Aziz-Alaoui M. Daher Okiye | 2003 | Applied Mathematics Letters2003，，7： | 2 |
| 11 | Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults显示文摘BACKGROUND Although the association of attention deficit hyperactivity disorder(ADHD)with psychiatric disorders is well known,its association with somatic diseases is unclear.Only few studies have investigated the gastrointestinal(GI)morbidity in adult patients with ADHD.AIM To measure gastrointestinal comorbidity and its burden on healthcare in young adults with ADHD.METHODS The cohort included subjects aged 17-35 years recruited to the Israel Defense Forces in 2007-2013,33380 with ADHD and 355652 without(controls).The groups were compared for functional and inflammatory conditions of the gastrointestinal tract and clinic and specialist visits for gastrointestinal symptoms/disease during service(to 2016).Findings were analyzed by generalized linear models adjusted for background variables.RESULTS Compared to controls,the ADHD group had more diagnoses of functional gastrointestinal disorders(referred to as FGID),namely,dyspepsia[odds ratio(OR):1.48,95%confidence interval(CI):1.40-1.57,P<0.001],chronic constipation(OR:1.64,95%CI:1.48-1.81,P<0.001),and irritable bowel syndrome(OR:1.67,95%CI:1.56-1.80,P<0.001)but not of organic disorders(inflammatory bowel disease,celiac disease).They had more frequent primary care visits for gastrointestinal symptoms[rate ratio(RR):1.25,95%CI:1.24-1.26,P<0.001]and referrals to gastrointestinal specialists(RR:1.96,95%CI:1.88-2.03,P<0.001)and more episodes of recurrent gastrointestinal symptoms(RR:1.29,95%CI:1.21-1.38,P<0.001).Methylphenidate use increased the risk of dyspepsia(OR:1.49,95%CI:1.28-1.73,P<0.001)and constipation(OR:1.42,95%CI:1.09-1.84,P=0.009).CONCLUSION ADHD in young adults is associated with an excess of FGID and increased use of related health services.Research is needed to determine if an integrative approach treating both conditions will benefit these patients and cut costs. | Sivan Kedem Shlomit Yust-Katz Dan Carter Zohar Levi Ron Kedem Adi Dickstein Salah Daher Lior H Katz | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 12 | Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopsthy显示文摘 | Daher Z Park YS Asnaghi V | 2004 | Diabetes2004，53，9： | 1 |
| 13 | Radioimmunolocalization of themonoclonal antibody J28 in early transformation stages in N-nitrosobis(2-hydroxypropyl) amine-induced pancreatictumors in the Syrian golden hamster显示文摘 | Takeda Y Miralles F Daher N | 1992 | J canceer Res Clin Oncol1992，118，： | 1 |
| 14 | Neurodegenerative phenotypes in an A53T-synuclein transgenic mouse model are independent of LRRK2 显示文摘 | Daher JP Pletnikova O Biskup S | 2012 | Hum Mol Genet2012，21，11： | 1 |
| 15 | Clinical and epidemiological features of visceral leishmaniasis and HIV co-infection in 15 patients from brazil显示文摘 | Daher EE Fonseca PP Gerhard ES | 2009 | J Parasitol2009，95，3： | 1 |
| 16 | QuikClot Combat Gauze use for hemorrhage control in military trauma: January 2009 Israel Defense Force experience in the Gaza Strip - - a preliminary report of 14 cases 显示文摘 | Ran Y Hadad E Daher S | 2010 | Prehosp Disaster Med2010，25，6： | 1 |
| 17 | Bladder augmentation and! or continent urinary diversion: IO-year experience 显示文摘 | Daher P Zeidan S Riachy E | 2007 | Eur J Pe?diatr Surg2007，17，2： | 1 |
| 18 | Development and testing of oral health care instructions in a multi-media form显示文摘 | Daher J | 1998 | Dtsc Zahnarztl Z1998，43，： | 1 |
| 19 | Induction of rat intestinal carcinogenesis with single doses, low and high repeated doses of 1,2-dimethylhydrazine 显示文摘 | Decaens C Gautier R Daher N | 1989 | Carcinogenesis1989，10，1： | 1 |
| 20 | Metabolic acidosis in AIDS patients显示文摘 | Daher EF Cezar LC Silva GB Jr | 2009 | Arch Med Res2009，40，2： | 1 |
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