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| 1 | 【特刊综述】肥胖男性低睾酮的发生机制、发病率及其处理显示文摘随着亚洲现代化和城市化的日益进展,肥胖流行病的未来焦点多在亚洲地区。肥胖男性常会出现低睾酮水平,但他们并不一定有可识别的下丘脑.垂体.睾丸轴(HPT)病理变化。中度肥胖主要降低总睾酮水平,这是由胰岛素抵抗相关的性激素结合球蛋白减少所致。比较严重的肥胖与游离睾酮水平降低有关,这是由下丘脑-垂体-睾丸轴的抑制所致。低睾酮本身可导致肥胖的高风险增加,产生一个恶性循环的代谢综合征。肥胖相关的低睾酮血症是一个功能状态,而非恒定状态。这种状态是可以被逆转的,但这需要持续的减肥。虽然睾酮治疗可以引起中度的脂肪减少,但肥胖本身,在没有雄激素缺乏症状的情况下,不是既定的睾酮治疗的适应症。睾酮治疗可能会导致未经治疗的睡眠呼吸暂停恶化,损害生育能力等。睾酮治疗是否增加饮食或者运动诱导的体重降低需要在充分设计的随机对照临床试验中评估。 | Mark Ng Tang Fui | 2014 | Asian Journal of Andrology2014，16，2： | 28 |
| 2 | Hematological changes during androgen deprivation therapy显示文摘雄激素剥夺治疗(ADT ) 与不利效果的过多被联系了,与多重繁殖、体的纸巾的雄激素相关性一致。一如此的纸巾是 hemopoietic 系统,并且 ADT 的最可预言的后果之一是贫血症的开发。尽管 ADT 引起的贫血症是很少严重, ADT 经常与增加的危险性被给脆弱的、老人到贫血症由于多重另外的原因。联系 ADT 的贫血症可以贡献疲劳并且减少在如此的人的生活(QoL ) 的质量,尽管这要求进一步的学习。当贫血症是在有前列腺癌症的人的死亡的一个独立风险因素时,联系 ADT 的贫血症的治疗是否改变临床上重要的结果,或治疗是否影响死亡,不被知道。导致 ADT 的贫血症的现象的了解应该在正常红血球的 normochromic 贫血症的温和情况中避免不必要的病情的检查。然而,对更多的严重贫血症的评价和治疗可以被要求。这应该在一个单个基础上被决定。与红血球生成上的 ADT 的描述得好的行动相对照,它另外的 hemopoietic 系上的效果是更少很好阐明。当现出症状之前的潜的研究在成熟为雄激素发现了角色并且区分了 neutrophils,淋巴细胞和血小板的功能时,为有收到 ADT 的前列腺癌症的人的这些调查结果的含意要求进一步的研究。 | Mathis Grossmann Jeffrey D Zajac | 2012 | Asian Journal of Andrology2012，14，2： | 9 |
| 3 | Diagnosis and treatment of hypogonadism in older men: proceed with caution显示文摘 | Mathis Grossmann | 2010 | Asian Journal of Andrology2010，12，6： | 4 |
| 4 | Testicular volume and clinical correlates of hypothalamic–pituitary–testicular function:A cross-sectional study in obese men显示文摘The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic–pituitary–testicular(HPT)axis function.This was a cross-sectional substudy of a larger randomized controlled trial including obese men,body mass index(BMI)≥30 kg m−2,with a total testosterone level<12 nmol l−1.Testicular volume was measured by orchidometer,testosterone by liquid chromatography/tandem mass spectrometry,and body composition by dual-energy X-ray absorptiometry.Men completed the Aging Males'Symptoms(AMS)score,International Index of Erectile Function-5(IIEF-5),physical function,and handgrip dynamometer testing.Eighty-nine men participated with a median(interquartile range[IQR])age of 53.1(47.6,59.2)years,BMI of 37.0(34.6,40.5)kg m−2,and a total testosterone of 7.0(6.1,7.9)nmol l−1.Median testicular volume was 18(IQR:10,20)ml.Testicular volume was negatively correlated with BMI(τ=−0.1952,P=0.010)and total fat mass(τ=−0.2115,P=0.005)independent of age and testosterone.When BMI,testosterone,sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were present in a multivariable model,only BMI(-0.38 ml change in testicular volume per 1 kg m-2BMI;95%CI:−0.74,−0.02;P=0.04)and LH(-0.92 ml change in testicular volume per 1 IU l-1 LH;95%CI:−1.75,−0.095;P=0.03)remained independent significant predictors of testicular volume.Testicular volume was positively correlated with IIEF-5(τ=0.2092,P=0.021),but not related to handgrip strength,physical function tests,or AMS.In obese men,testicular volume is inversely and independently associated with measures of adiposity,but not with most clinical or biochemical markers of HPT axis action.From a clinical perspective,this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men. | Mark Ng Tang Fui Rudolf Hoermann Gary Wittert Mathis Grossmann | 2020 | Asian Journal of Andrology2020，22，4： | 1 |
| 5 | 【特刊综述】男性雄激素缺乏:一种多系统综合征显示文摘雄性激素对于多器官系统有重要影响,而这些器官系统对男性一生的健康比如调节性功能、身体功能和行为学功能起着决定性作用。雄激素缺乏是一种多系统综合征,表现出与明显的血清睾酮低水平相关的典型临床特征。雄激素缺乏的临床表现因年龄和其它诸如并存病、遗传因素、环境因素及社会文化因素等患者个体特性而不同。 | Mathis Grossmann Frederick C Wu | 2014 | Asian Journal of Andrology2014，16，2： | 1 |
| 6 | Testosterone treatment in older men: glass half empty or half full?显示文摘在在 JAMA 和 JAMA 实习生 Med 出版的一系列使随机化的控制试用,美国研究人员与睾丸激素层次在老人检验了睾丸激素治疗的效果<冠的动脉匾体积上的 275 ng dl 1, 1 认知功能, 2 贫血症, 3 并且容量的骨头 density.4 当试用在贫血症和骨头密度关于改进显示出积极结果时,长术语的研究被要求描出在这张人口的长期的风险和好处。 | Brendan J Nolan Mathis Grossmann | 2017 | Asian Journal of Andrology2017，19，5： | 0 |
| 7 | COX-2 inhibitors in prostate cancer treatment--hold your horses?显示文摘 | Ada S Cheung Mathis Grossmann | 2012 | Asian Journal of Andrology2012，14，4： | 0 |
| 8 | Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in people with diabetes with no available treatment.AIM To explore the effect of testosterone treatment on liver.Testosterone therapy improves insulin resistance and reduces total body fat,but its impact on the liver remains poorly studied.METHODS This secondary analysis of a 40 wk,randomised,double-blinded,placebocontrolled trial of intramuscular testosterone undecanoate in men with type 2 diabetes and lowered serum testosterone concentrations evaluated the change in hepatic steatosis as measured by liver fat fraction on magnetic resonance imaging(MRI).RESULTS Of 88 patients enrolled in the index study,39 had liver MRIs of whom 20 received testosterone therapy and 19 received placebo.All patients had>5%hepatic steatosis at baseline and 38 of 39 patients met diagnostic criteria for NAFLD.Median liver fat at baseline was 15.0%(IQR 11.5%-21.1%)in the testosterone and 18.4%(15.0%-28.9%)in the placebo group.Median ALT was 34units/L(26-38)in the testosterone and 32units/L(25-52)in the placebo group.At week 40,patients receiving testosterone had a median reduction in absolute liver fat of 3.5%(IQR 2.9%-6.4%)compared with an increase of 1.2%in the placebo arm(between-group difference 4.7%P<0.001).After controlling for baseline liver fat,testosterone therapy was associated with a relative reduction in liver fat of 38.3%(95%confidence interval 25.4%-49.0%,P<0.001).CONCLUSION Testosterone therapy was associated with a reduction in hepatic steatosis in men with diabetes and low serum testosterone.Future randomised studies of testosterone therapy in men with NAFLD focusing on liver-related endpoints are therefore justified. | Ross Apostolov Emily Gianatti Darren Wong Numan Kutaiba Paul Gow Mathis Grossmann Marie Sinclair | 2022 | World Journal of Hepatology2022，14，4： | 0 |
| 9 | Plasma miRNA expression profile in the diagnosis o' late-onset hypogonadism显示文摘在自然杂志报导科学 Reports1 的研究人员使用了定序的下一代和量的反向的 transcriptase PCR (RT-PCR ) 技术介绍血浆 microRNA (miRNA ) 在有或没有迟了发作的性腺机能减退(LOH ) 的人的队的表示。学习作为新奇 biomarkers 建议三 miRNAs 的一块面板帮助 LOH 的诊断。 | Nicholas Russell Mathis Grossmann | 2016 | Asian Journal of Andrology2016，18，5： | 0 |
| 10 | ndrogen-deprivation therapy in men with metastatic rostate cancer: less may not necessarily be more显示文摘 | Mark Ng Tang Fui | 2013 | Asian Journal of Andrology2013，15，4： | 0 |
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