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| 1 | Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis. | Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar | 2008 | World Journal of Gastroenterology2008，14，17： | 11 |
| 2 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 3 | Specification-Based Prototyping for Embedded Systems显示文摘 | Mats P E Heimdahl Steven p Miller | 1999 | Software Eng Notes1999，24，6： | 1 |
| 4 | Investigation of High-Efficiency Surface-Emitting Lasers with Blazed Grating Outcouplers 显示文摘 | Mats Hagberg Anders Larsson N E | 1996 | IEEE Journal of Quantum Electronics1996，32，9： | 1 |
| 5 | Variations in peripheral blood levels of immunoreactive tumor necrosis a throughout the menstrual cycle and secretios of TNFa from the human corpus luteum显示文摘 | MATS B BARBRO E MELACDA J | 1999 | European J Obste & Gynecol & Reprod Biol1999，83，2： | 1 |
| 6 | High-speed heck reactions in ionic liquid with controlled microwave heating 显示文摘 | KARL S A V PER E MATS L | 2002 | J Org Chern2002，67，17： | 1 |
| 7 | Anaerobic treatment of animal by- products from slaughterhouses at laboratory and pilot scale 显示文摘 | Mats E Ake N Lennart T | 2003 | Applied Biochemistry and Biotechnology2003，109，： | 1 |
| 8 | Solubilization, purification and properties of mem- brane-bound glycerol dehydrogenase from Gluconobacter industrius显示文摘 | AMEYAMA M SHINAGAWA E MAT SUSHITA K | 1985 | Agric Biol Chem1985，49，4： | 1 |
| 9 | Piffusion-weighted imaging of maiignant breast tumors: the usefulness of apparent diffusion coefficient (ADO) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension显示文摘 | Woodhams E Mat sunaga K lwabuchi K et ai | 2005 | J Comput Assist Tomogr2005，29，4： | 1 |
| 10 | Environmental Brownian noise suppresses explosions in populations dynamics显示文摘 | Mat X Marion G Renshaw E | 2002 | Stochastic Process Appl2002，97，： | 1 |
| 11 | Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products显示文摘 | MATS A MARGARETHA A E MICHAEL S M | 2006 | Science of the Total Environment2006，372，1： | 1 |
| 12 | Fr equency of tumor recurrence: a strong predict or of stage progression in initially diagnosed nonmus cleinvasive bladder cancer 显示文摘 | Tanaka N Kikuchi E Mat sumoto K | 2011 | J Urol2011，185，2： | 1 |
| 13 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 14 | Asymptotic properties of nonlinear weighted least squares in radar array processing 显示文摘 | Jonny E Mats V | 2004 | IEEETransactions on Signal Processing2004，52，11： | 1 |
| 15 | Rotavirus surveillance in Europe, 2005-2008: web-enabled repor- ting and real-time analysis of genotyping and epidemio- logical data显示文摘 | Iturriza-Gomara M Dallman T Banyai K Bottiger B Buesa J Diedrich S Fiore L Johansen K Korsun N Kroneman A Lappalainen M Laszlo B Maunula L Mat thinjnssens J Midgley S Mladenova Z Poljsak-Prijatelj M Pothier P Ruggeri F M Sanchez-Fauquier A Schreier E Steyer A Sidaraviciute I Tran A N Usonis V Van Ranst M de Rougemont A Gray J | 2009 | J Infect Dis2009，2001，： | 1 |
| 16 | Red blood cell rheological alterations in a rat model of ischemia-reperfusion injury 显示文摘 | Kayar E Mat F Meiselman H J | 2001 | Biorheology2001，38，56： | 1 |
| 17 | 6 V显示文摘 | MATS E HOVIN DAG T WISLAND YNGVAR BERG et aL A Frequency Deha-Sigma Analog-to- Digital Converter Operating at a Power-Supply Voltage of 0 | 2003 | Analog Integrated Circuits and Signal Processing2003，34，1： | 1 |
| 18 | Bioactivation of tegafur to 5 - fluorouraeil is cat alyzed by eytochrome P -450 2A6 in hu- man liver microsomes in vitro 显示文摘 | Ikeda K Yoshisue K Mat sushima E | 2000 | Clin Cancer Res2000，6，11： | 1 |
| 19 | Removal of estrogenic on Swedish municipal sewage treatment plants 显示文摘 | Svenson A Allard A S Mats E K | 2003 | Water Research2003，37，： | 1 |
| 20 | B-D-glucan as a diagnostic ad- junct for invasive fungal infections: validation, cutoff development, and performance inpatients with acute myelogenous leukemia and myelodys plastic syndrome 显示文摘 | Odabasi Z Mat tiuzzi G Estey E | 2004 | Clin Infect Dis2004，39，2： | 1 |
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