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| 1 | Stroke in young people显示文摘 | Díaz-Marín C Matías-Guiu J | 1996 | Rev Neu-rol1996，24，126： | 1 |
| 2 | Contra:Antithrombotic therapy with warfarin,aspirin and colpidogrel is the recommended regimen in anticoagulated patients who present with an acute coronary syndrome and/or precutaneous coronary interventions显示文摘 | Vanessa Roldán Francisco Matín | 2008 | Thromb Heamost2008，100，5： | 1 |
| 3 | n-3 Fatty acid supplementation in burned paediatric patients显示文摘 | Matín MC Osimani NE Rey GE | | 0，，12： | 1 |
| 4 | Deep modulation technique for optical phase detection显示文摘 | G Heinzel F Guzmán Cervantes A F García Matín | 2010 | Opt Express2010，，4： | 1 |
| 5 | Orthostatic and postprandial hypotension in elderly patients with chronic diseases and disability:prevalence and related factors显示文摘 | Villavicencio-Chávez C Miralles Basseda R González Matín P | 2009 | Rev Esp Geriatr Gerontol2009，44，1： | 1 |
| 6 | Transcystic common bile duct exploration in the management of patients with choledocholithiasis显示文摘 | Rojas OS Arizpe BD Matín LE | 2003 | Gastrointest Surg2003，7，4： | 1 |
| 7 | ECM regulates MT1-MMP localization with betal or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity an human endothelial cells显示文摘 | Gálvez B G Matías-Román S Yá(n)ez-MóM | 2002 | J Cell Bio2002，159，3： | 1 |
| 8 | Supercritical antisolvent precipitation from an emulsion:β-carotene nanoparticle formation显示文摘 | Mattea F Martíná Matías-Gago A | 2009 | The Journal of Supercritical Fluids2009，51，2： | 1 |
| 9 | Soybean yield as affected by biomass and nitrogen uptake of cereal rye in winter cover crop rotations显示文摘 | Matías L R Donald G B Germán A B | 2004 | Agronomy Journal2004，96，3： | 1 |
| 10 | Proteome profile changes during mouse testis development显示文摘 | María Paz Matías Morín Jesús del Mazo | 2006 | Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics2006，，4： | 1 |
| 11 | REVIEW: Role of 5-Aminosalicylic Acid (5-ASA) in Treatment of Inflammatory Bowel Disease: A Systemic Review显示文摘 | Javier P. Gisbert Fernando Gomollón José Maté José María Pajares | 2002 | Digestive Diseases and Sciences2002，，3： | 1 |
| 12 | ICT in Chile at the Beginning of the Fourth Industrial Revolution显示文摘This paper shows the current status of companies in the information and communication technology(ICT)sector in Santiago,Chile.It presents the results of interviews with 13 ICT companies,reviewing structural elements that determine the development of the sector.For this purpose,a qualitative analysis of that interviewed group is carried out to identify their different linkages and work dynamics.This sector has a great capacity for stimulating innovative development throughout the national economy,a key element in the paradigmatic change that the so-called fourth industrial revolution imposes on us. | Francisco Gatica Neira Gonzalo Falabella García Matías Calderón Seguel | 2018 | Chinese Business Review2018，17，6： | 0 |
| 13 | Agronomic characterization of diploid hybrid families derived from crosses between haploids of the common potato and three wild Argentinian tuber-bearing species显示文摘 | Matías Santini Elsa Lucila Camadro Olga Noemí Marcellán Luis Ernesto Erazzú | 2000 | American Journal of Potato Research2000，，4： | 1 |
| 14 | Photonic Crystal Fiber Temperature Sensor Based on Quantum Dot Nanocoatings显示文摘 | Beatriz Larrión Miguel Hernáez Francisco J. Arregui Javier Goicoechea Javier Bravo Ignacio R. Matías Valerio Pruneri | 2009 | Journal of Sensors2009，，： | 1 |
| 15 | Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection显示文摘Dear Editor,Drug repurposing is a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent,as is the case of emerging pathogens.In recent years,approaches based on network biology have demonstrated to be superior to genecentric ones.1 Here,we use an innovative methodology that combines mechanistic modeling of the signal transduction circuits related to SARS-CoV-2 infection(the COVID-19 disease map)with a machine-learning algorithm that learns potential causal interactions between proteins,already targets of drugs,and specific signaling circuits in the COVID-19 disease map,to suggest potentially repurposable drugs. | Carlos Loucera Marina Esteban-Medina Kinza Rian Matías M.Falco Joaquín Dopazo María Peña-Chilet | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 16 | Adverse events of thiopurine immunomodulators in patients with inflammatory bowel disease显示文摘 | Cristina López-Martín María Chaparro Laura Espinosa Alicia Bejerano José Maté Javier P. Gisbert | 2011 | Gastroenterologia y Hepatologia2011，，6： | 1 |
| 17 | Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells显示文摘Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases worldwide.In general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine factors.Parathyroid hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological processes.It exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly paracrine.It has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral hypercalcemia.Eight years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC cells.Based on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in CRC.We analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells features.This work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressive phenotype of CRC cells and the molecular mechanisms involved in these processes.Recently,we found that this cytokine induces this malignant behavior not only by its direct action on these intestinal cells but also through its influence on cells derived from TME,promoting a communication between CRC cells and surrounding cells that contributes to the molecular and morphological changes observed in CRC cells.These investigations establish the basis for our next studies in order to address the clinical applicability of our findings.Recognizing the factors and mechanisms that promote invasion in CRC cells,evasion to the cytotoxic effects of current CRC therapies and thus metastasis is decisive for the identification of new markers with the potential to improve early diagnosis and/or to predict prognosis,to predetermine drug resistance and to provide treatment guidelines that include targeted therapies for this disease. | María Belén Novoa Díaz Pedro Matías Carriere María Julia Martín Natalia Calvo Claudia Gentili | 2021 | World Journal of Gastroenterology2021，27，41： | 0 |
| 18 | Safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and chronic viral hepatitis B or C: a retrospective, multicentre study in a clinical setting显示文摘 | R. Navarro E. Vilarrasa P. Herranz L. Puig X. Bordas J.M. Carrascosa R. Taberner M. Ferrán M. García‐Bustinduy A. Romero‐Maté R. Pedragosa A. García‐Diez E. Daudén | 2013 | British Journal of Dermatology2013，，3： | 1 |
| 19 | Thiopurine Methyltransferase Activity in Spain: A Study of 14,545 Patients显示文摘 | Javier P. Gisbert Fernando Gomollón Carlos Cara Marta Luna Yago González-Lama José María Pajares José Maté Luis G. Guijarro | 2007 | Digestive Diseases and Sciences2007，，5： | 1 |
| 20 | Health Care Costs of Complex Perianal Fistula in Crohn’s Disease显示文摘 | M. Chaparro C. Zanotti P. Burgue?o I. Vera F. Bermejo I. Marín-Jiménez C. Yela P. López M. D. Martín C. Taxonera B. Botella R. Pajares A. Ponferrada M. Calvo A. Algaba L. Pérez B. Casis J. Maté J. Orofino N. Lara M. García-Losa X. Badia J. P. Gisbert | 2013 | Digestive Diseases and Sciences2013，，12： | 1 |
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