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| 1 | 中国主要土壤高光谱反射特性分类与有机质光谱预测模型显示文摘土壤可见-近红外漫反射光谱是当前对地遥感观察和土壤近地传感器研究的重要方向,同时也被认为是土壤数字制图、精确农业和土壤资源调查等方面最重要的数据获取技术. 从中国西藏、新疆、黑龙江、海南等地采集16种土类的1581个土壤样本,经干燥过筛后统一采用 ASD光谱仪测量了其室内可见-近红外反射光谱(350-2500 nm). 对所有的土壤光谱数据采用Savitzky-Golay平滑加一阶微分进行转换,来减少大样本数据受到实验室光学测试环境条件差异的影响,然后对数据进行主成分变换降维处理. 引入模糊k-means方法进行大样本光谱数据的最佳分类数目计算,并将中国土壤光谱数据分成五类,各自代表了不同的土壤矿物和有机组分,主要类型与国际同行类似成果有可比性. 最后提出了采用土壤光谱分类方法结合偏最小二乘回归法(PLSR)方法建立土壤有机质的光谱分类-局部预测模型,结果比未分类直接采用PLSR方法的一阶微分-全局预测模型的精度有了显著提高,其预测模型的R2和RPD两个指数分别从0.697和1.817提高到0.899和3.158. | 史舟 王乾龙 彭杰 纪文君 刘焕军 李曦 Raphael A VISCARRA ROSSEL | 2014 | 中国科学:地球科学2014，44，5： | 100 |
| 2 | 中国旅游教育发展现状与对策研究显示文摘通过对全国范围内200家旅游院校的调查,本文旨在指出中国旅游教育的特点和存在的问题,问卷显示,由于中国旅游业的不断发展,中国旅游教育院校的数量在10年中有了长足的发展。但是,在师资力量,学生实践经验以及国际化程度方面有待于进一步的提高。调查结果也显示了影响学生进入或留在旅游行业的因素中,薪酬是最重要的一个因素。 | 谷慧敏 Raphael R.Kavanaugh 俞聪 | 2005 | 旅游学刊2005，20，S1： | 46 |
| 3 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 4 | Development of a national VNIR soil-spectral library for soil classification and prediction of organic matter concentrations显示文摘Soil visible-near infrared diffuse reflectance spectroscopy(vis-NIR DRS)has become an important area of research in the fields of remote and proximal soil sensing.The technique is considered to be particularly useful for acquiring data for soil digital mapping,precision agriculture and soil survey.In this study,1581 soil samples were collected from 14 provinces in China,including Tibet,Xinjiang,Heilongjiang,and Hainan.The samples represent 16 soil groups of the Genetic Soil Classification of China.After air-drying and sieving,the diffuse reflectance spectra of the samples were measured under laboratory conditions in the range between 350 and 2500 nm using a portable vis-NIR spectrometer.All the soil spectra were smoothed using the Savitzky-Golay method with first derivatives before performing multivariate data analyses.The spectra were compressed using principal components analysis and the fuzzy k-means method was used to calculate the optimal soil spectral classification.The scores of the principal component analyses were classified into five clusters that describe the mineral and organic composition of the soils.The results on the classification of the spectra are comparable to the results of other similar research.Spectroscopic predictions of soil organic matter concentrations used a combination of the soil spectral classification with multivariate calibration using partial least squares regression(PLSR).This combination significantly improved the predictions of soil organic matter(R2=0.899;RPD=3.158)compared with using PLSR alone(R2=0.697;RPD=1.817). | SHI Zhou WANG QianLong PENG Jie JI WenJun LIU HuanJun LI Xi Raphael A VISCARRA ROSSEL | 2014 | Science China Earth Sciences2014，57，7： | 32 |
| 5 | Review on current advances,future challenges and consideration issues for post-combustion CO_2 capture using amine-based absorbents显示文摘Among the current technologies for post-combustion CO2 capture,amine-based chemical absorption appears to be the most technologically mature and commercially viable method.This review highlights the opportunities and challenges in post-combustion CO2 capture using amine-based chemical absorption technologies.In addition,this review provides current types and emerging trends for chemical solvents.The issues and performance of amine solvents are reviewed and addressed in terms of thermodynamics,kinetics,mass transfer,regeneration and solvent management.This review also looks at emerging and future trends in post-combustion CO2 capture using chemical solvents in the near to mid-term. | Zhiwu Liang Kaiyun Fu Raphael Idem Paitoon Tontiwachwuthikul | 2016 | Chinese Journal of Chemical Engineering2016，24，2： | 26 |
| 6 | Laparoscopic liver resection:Experience based guidelines显示文摘Laparoscopic liver resection(LLR) has been progressively developed along the past two decades. Despite initial skepticism, improved operative results made laparoscopic approach incorporated to surgical practice and operations increased in frequency and complexity. Evidence supporting LLR comes from case-series, comparative studies and meta-analysis. Despite lack of level 1 evidence, the body of literature is stronger and existing data confirms the safety, feasibility and benefits of laparoscopic approach when compared to open resection. Indications for LLR do not differ from those for open surgery. They include benign and malignant(both primary and metastatic) tumors and living donor liver harvesting. Currently, resection of lesions located on anterolateral segments and left lateral sectionectomy are performed systematically by laparoscopy in hepatobiliary specialized centers. Resection of lesions located on posterosuperior segments(1, 4a, 7, 8) and major liver resections were shown to be feasible but remain technically demanding procedures, which should be reserved to experienced surgeons. Hand-assisted and laparoscopy-assisted procedures appeared to increase the indications of minimally invasive liver surgery and are useful strategies applied to difficult and major resections. LLR proved to be safe for malignant lesions and offers some short-term advantages over open resection. Oncological results including resection margin status and long-term survival were not inferior to open resection. At present, surgical community expects high quality studies to base the already perceived better outcomes achieved by laparoscopy in major centers' practice. Continuous surgical training, as well as new technologies should augment the application of lap-aroscopic liver surgery. Future applicability of new technologies such as robot assistance and image-guided surgery is still under investigation. | fabricio ferreira coelho jaime arthur pirola kruger gilton marques fonseca raphael leonardo cunha araújo vagner birk jeismann marcos vinícius perini renato micelli lupinacci ivan cecconello paulo herman | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 22 |
| 7 | 透水再生骨料混凝土研究进展显示文摘透水再生骨料混凝土(PRAC)是近年来新兴的一种环境友好型混凝土,利用建筑废弃物破碎所得再生骨料置换天然骨料,改善传统混凝土在城市路面建设中的弊端,实现废物资源再利用和建筑材料的可持续发展。总结了水灰比、孔隙率、再生骨料粒径和取代率、成型工艺等因素对透水再生骨料混凝土力学性能、透水性以及耐久性的影响,并提出了有待进一步研究的问题。已有研究成果表明再生骨料可以用于制备透水混凝土,应用于停车场、人行道及植生护坡等工程。 | 陈尚权 高越青 梁超锋 Raphael Desire 邵晓蓉 | 2020 | 硅酸盐通报2020，39，1： | 18 |
| 8 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 9 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 10 | Turning rice meiosis into mitosis显示文摘通过在庄稼的种子(单性生殖) 的同种细胞的复制的介绍有潜力由允许任何精英变化的自我繁殖革命化农业,特别地 F1 混血儿。在性模型植物 Arabidopsis thaliana,通过种子的合成同种细胞的复制能被联合三个变化把成熟分裂变成有丝分裂(笑剧) 并且(的(i) 人工地实现 ii ) 穿过获得的同种细胞的配偶子,一根线表示修改了 CENH3 并且其染色体在接合子被消除。这里,我们证明变化的另外的联合能把 Arabidopsis 成熟分裂变成有丝分裂并且在米饭(Oryza sativa ) 的三个变化的联合高效地把成熟分裂变成有丝分裂,导致在这主要庄稼的男、女的同种细胞的双配偶子的生产。在种系发生地远的 eudicot Arabidopsis 和 monocot 米饭的笑剧技术的成功的实现为它的申请打开门到任何 flowering 植物并且为在庄稼种类介绍单性生殖铺平道路。 | Delphine Mieulet Sylvie Jolivet Maud Rivard Laurence Cromer Aurore Vemet Pauline Mayonove Lucie Pereira Gaetan Droc Brigitte Courtois Emmanuel Guiderdoni Raphael Mercier | 2016 | Cell Research2016，26，11： | 14 |
| 11 | 青藏高原东南缘芒康地区河流地貌演化的磷灰石U-Th/He记录显示文摘青藏高原东南缘地处印度与欧亚板块碰撞侧向逃逸的特殊构造部位,地势起伏相对较缓,形成三江并流的独特地貌格局。然而,对于东南缘大尺度地形地貌形成机制与水系演化的认识仍存在很大的分歧。本文获得的澜沧江流域芒康地区5个基岩样品磷灰石U-Th/He年龄表明该地区在早一中中新世(23-15Ma)经历了一次区域性冷却事件,且冷却速率在5Ma期间从40℃/Ma降低到28℃/Ma以下。目前可获得的青藏高原东缘一东南缘的低温年代学数据表明:尽管川西一藏东一滇北一带具有相似地貌特征,但高海拔、低起伏地貌面的形成是穿时性的,不能将它作为一个区域上连续的等时面来计算和探讨一个统一的区域抬升启动时间;三江地区地形属于非稳态的过渡型地形,尤其芒康一左贡地区剥蚀速率的差异比较清晰地展示了澜沧江流域地形演化处于非稳态期。此外,河流下切是塑造澜沧江流域的地形地貌主要驱动力之一:干流的侵蚀速率远远高于支流的侵蚀速率;河流下切强烈的地区(如德钦)对应的侵蚀速率及地形起伏度都较大,芒康地区微弱的地形起伏度取决于较低的侵蚀速率。第三纪以来的印度一欧亚板块碰撞导致青藏高原崛起的同时,也对周边尤其藏东南三江地区的地形地貌塑造及气候变化产生重大的影响。 | 肖萍 刘静 王伟 钟宁 曾令森 Raphael Pik 谢克家 | 2015 | 第四纪研究2015，35，2： | 12 |
| 12 | 颈动脉内膜剥脱术在中国的实践与探索显示文摘在中国,脑卒中是导致死亡的第一位原因,在这个占世界人口1/5的国家,大约就有700万脑卒中患者。据最近的流行病学统计,中国每年有新发脑卒中患者200万例,且每年因脑卒中而导致的死亡人数达100万。然而相对于如此大的脑卒中人群而言,目前我国在脑卒中预防方面还比较滞后。据不完全统计,国内每年所开展的颈动脉内膜剥脱术不足200例。而在美国,颈动脉内膜剥脱术已经成为最普通的血管外科手术。 | 张勤奕 Douglas J.Wirthlin 屈根学 孟昕 郑刚 Raphael C.SunBS 王乃栋 Donald B.Doty | 2009 | 中华老年心脑血管病杂志2009，11，3： | 11 |
| 13 | Metastatic gastric cancer treatment: Second line and beyond显示文摘Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy(SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients' well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with a GC. | Marwan Ghosn Samer Tabchi Hampig Raphael Kourie Mustapha Tehfe | 2016 | World Journal of Gastroenterology2016，22，11： | 10 |
| 14 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 15 | A formal approach using SysML for capturing functional requirements in avionics domain显示文摘In this work,a Model-Based Systems Engineering approach based on Sys ML is proposed.This approach is used for the capture and the definition of functional requirements in avionics domain.The motivation of this work is triple:guide the capture of functional requirements,validate these functional requirements through functional simulation,and verify efficiently the consistency of these functional requirements.The proposed approach is decomposed into several steps that are detailed to go from conceptual model of avionics domain to a formal functional model that can be simulated in its operating context.To achieve this work,a subset of Sys ML has been used as an intermediate modelling language to ensure progressive transformation that can be understood and agreed by system stakeholders.Formal concepts are introduced to ensure theoretical consistency of the approach.In addition,transformation rules are defined and the mappings between concepts of ARP4754 A civil aircraft guidelines and Sys ML are formalized through meta-model.The resulting formalization enables engineers to perform functional simulation of the top-level functional architecture extracted from operational scenarios.Finally,the approach has been tested on an industrial avionics system called the Onboard Maintenance System. | Shaofan ZHU Jian TANG Jean-Marie GAUTHIER Raphael FAUDOU | 2019 | Chinese Journal of Aeronautics2019，32，12： | 8 |
| 16 | Adipose tissue lipolysis and remodeling during the transition period of dairy cows显示文摘Elevated concentrations of plasma fatty acids in transition dairy cows are significantly associated with increased disease susceptibility and poor lactation performance. The main source of plasma fatty acids throughout the transition period is lipolysis from adipose tissue depots. During this time, plasma fatty acids serve as a source of calories mitigating the negative energy balance prompted by copious milk synthesis and limited dry matter intake.Past research has demonstrated that lipolysis in the adipose organ is a complex process that includes not only the activation of lipolytic pathways in response to neural, hormonal, or paracrine stimuli, but also important changes in the structure and cellular distribution of the tissue in a process known as adipose tissue remodeling. This process involves an inflammatory response with immune cell migration, proliferation of the cellular components of the stromal vascular fraction, and changes in the extracellular matrix. This review summarizes current knowledge on lipolysis in dairy cattle, expands on the new field of adipose tissue remodeling, and discusses how these biological processes affect transition cow health and productivity. | G.Andres Contreras Clarissa Strieder-Barboza William Raphael | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 8 |
| 17 | 阿司匹林——预防关节置换术后肺栓塞的新选择?显示文摘对于施行全关节置换术(total joint arthroplasty,TJA)的患者,术后预防静脉血栓(venous thromboembolism,VTE)的理想方法目前仍不明确。华法林是常用的VTE预防药物,尽管有效,但患者肺栓塞(pulmonary embolism,PE)、深静脉血栓(deep vein thrombosis,DVT)发生率及出血风险明显提高,需要定期监测。 | Raphael IJ Tischler EH Huang R 杨庆磊 尹庆水 | 2014 | 中国骨科临床与基础研究杂志2014，6，3： | 7 |
| 18 | Optimum chemotherapy in the management of metastatic pancreatic cancer显示文摘Pancreatic cancer is one of the most devastating solid tumors,and it remains one of the most difficult to treat.The treatment of metastatic pancreatic cancer(MPC)is systemic,based on chemotherapy or best supportive care,depending on the performance status of the patient.Two chemotherapeutical regimens have produced substantial benefits in the treatment of MPC:gemcitabine in 1997;and FOLFIRIONOX in 2011.FOLFIRINOX improved the natural history of MPC,with overall survival(OS)of 11.1 mo.Nab-paclitaxel associated with gemcitabine is a newly approved regimen for MPC,with a median OS of 8.6 mo.Despite multiple trials,this targeted therapy was not efficient in the treatment of MPC.Many new molecules targeting the proliferation and survival pathways,immune response,oncofetal signaling and the epigenetic changes are currently undergoing phaseⅠandⅡtrials for the treatment of MPC,with many promising results. | Marwan Ghosn Hampig Raphael Kourie Fadi El Karak Colette Hanna Joelle Antoun Dolly Nasr | 2014 | World Journal of Gastroenterology2014，20，9： | 7 |
| 19 | Obesity in kidney disease:A heavyweight opponen显示文摘Obesity is an important worldwide challenge that must be faced in most developed and developing countries because of unhealthy nutritional habits.The consequences of obesity and being overweight are observed in different organs,but the kidney is one of the most affected.Excess adipose tissue causes hemodynamic alterations in the kidney that can result in renal disease.However,obesity is also commonly associated with other comorbidities such as chronic inflammation,hypertension and diabetes.This association of several aggravating factors is still a matter of concern in clinical and basic research because the pathophysiologic mechanisms surrounding chronic kidney disease development in obese patients remain unclear.This review will discuss the consequences of obesity in the context of renal injury. | Raphael Jose Ferreira Felizardo Marina Burgos da Silva Cristhiane Favero Aguiar Niels Olsen Saraiva Camara | 2014 | World Journal of Nephrology2014，3，3： | 7 |
| 20 | Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer显示文摘Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of malignancies.VTE includes two identical entities with regards to deep vein thrombosis and pulmonary embolism.The incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without prophylaxis.Prophylactic use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been described.Nevertheless,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d post-opera-tively.The aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted protocols.In addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease. | Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras Nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos Nikolaos Arkadopoulos | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 7 |
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