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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Chlorophyll concentrations and photosynthesis in three forest understory mosses in northeastern Kansas 显示文摘 | MCCALL K K MARTIN C E | 1991 | Bryologist1991，94，1： | 2 |
| 5 | 钒微合金化钢的热影响区韧性显示文摘研究了结构钢单道次焊接接头,尤其是靠近融合线位置的粗晶热影响区(CGHAZ)的组织和力学性能。通常,这个区域的韧性比母材和焊缝金属的韧性要低很多,所以CGHAZ是最容易发生断裂的薄弱位置。重点关注钒微合金化钢板,并且与相同强度级别的铌微合金化钢板进行对比。为了充分利用钒的强化效果,有必要将氮含量提高至0.01%;为优化钢的性能,必须考虑钒与氮的配合。 | Fahlstrm K Hutchinson B Komenda J Lindh-Ulmgren E Martin D Beladi H 师仲然 王瑞珍 | 2015 | 钢铁钒钛2015，36，3： | 2 |
| 6 | Onion - type micelles in aqueous media 显示文摘 | Procháa K Martin T J Webber S E | 1996 | Macromolecules1996，29，： | 1 |
| 7 | Aerial application methods for increasing spray deposition on wheat heads 显示文摘 | Fritz B K Hoffmann W C Martin D E | 2007 | Applied Engineering in Agriculture2007，23，6： | 1 |
| 8 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 9 | Imagery use in sport:A literature review and applied model 显示文摘 | Martin K A Moritz S E Hall C R | 1999 | The Sport Psychologist1999，13，24： | 1 |
| 10 | WACS--wide-area stability and voltage control system: R g~ D and online demonstration 显示文摘 | TAYLOR C W ERICKSON D C MARTIN K E | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 11 | Effect of partial resistance on Phytophthora stem rot incidence and yield of soybean in Ohio显示文摘 | Dorrance A E McClure S A Martin S K | 2003 | Plant Dis2003，87，： | 1 |
| 12 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 13 | Molecular cloning and nucleotide sequence of the alphatoxin (phospholipase c) of Clostridium perfringens 显示文摘 | HUNTER S E C MARTIN K L | 1989 | Infect Immun1989，57，2： | 1 |
| 14 | Optical properties of a-HfO2 thin films 显示文摘 | Jebreel M K Martin E K | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 15 | Tourism development in Mallorca: Is water supply a constraint? 显示文摘 | Stephen E Martin K Rewi Newnham | 2004 | Journal of Sustainable Tourism2004，12，1： | 1 |
| 16 | NEPTUNE Study: On-treatment HBsAg level analysis confirms prediction of response observed in phase 3 study of peginterferon alfa-2a in HBeAg-positive patients 显示文摘 | Gane E Jia J Han K Tanwandee T Chuang WL Marcellin P Chan HL Piratvisuth T Wat C Martins E Liaw YF | 2011 | J Hepatol2011，54，： | 1 |
| 17 | Use of the WECC WAMS in wide-area probing tests for validation of system performance and modeling显示文摘 | HAUER J F0 MITTELSTADT W A MARTIN K E | 2009 | IEEE Trans on Power Systems2009，24，1： | 1 |
| 18 | Diabe- tes mellitus and Alzheimer's disease: shared patholo- gy and treatment? 显示文摘 | AKTER K LANZA E A MARTIN S A | 2011 | Br J Clin Pharmacol2011，71，3： | 1 |
| 19 | 查看详情显示文摘 | Irish E K Gea-Banacloche J Martin I Schwab K C | | 0，，： | 1 |
| 20 | Purification and properties of a novel insulin-like growth factor-If binding protein from transformed human fibroblasts 显示文摘 | Martin J L Willetts K E Baxter R C | 1990 | The Journal of biological chemistry1990，265，7： | 1 |
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