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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates显示文摘Dear Editor,Omicron(B.1.1.529),is a heavily mutated and highly contagious SARS-CoV-2 variant,which is currently causing large outbreaks in many countries.Protection provided by current vaccines is substantially reduced against Omicron.1,2 Moreover,many immunocompromised individuals cannot effectively be protected by vaccines.3 Hence,antiviral therapies will be essential to protect the most vulnerable individuals from severe COVID-19. | Denisa Bojkova Marek Widera Sandra Ciesek Mark N.Wass Martin Michaelis Jindrich Cinatl Jr | 2022 | Cell Research2022，32，3： | 10 |
| 3 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 4 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 5 | Laboratory evaluation of the GreenSeeker^(TM) handheld optical sensor to variations in orientation and height above canopy显示文摘Handheld optical sensors recently have been introduced to the agricultural market.These handheld sensors are able to provide operators with Normalized Difference Vegetative Index(NDVI)data when cloud cover prevents acquisition of satellite or aerial images.This research addressed the sensitivity of the GreenSeeker handheld optical sensor to changes in orientation and height above a ryegrass canopy.Planter boxes were oriented both parallel and perpendicular to the light beam from the sensor head and heights of 30.5 cm(12”),61.0 cm(24”),91.5 cm(36”),122 cm(48”)and 152 cm(60”)were tested.Results indicated that the sensor was highly sensitive(P<0.0001)to both height above canopy and orientation of the sensor relative to the target.Operators should follow manufacturer’s recommendations on operating height range of 81-122 cm and orient the sensor head in-line with the target to obtain maximum signal response. | Daniel E Martin Juan D Lopez Jr Yubin Lan | 2012 | International Journal of Agricultural and Biological Engineering2012，5，1： | 2 |
| 6 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 7 | 农业氨减排对大气PM_(2.5)污染治理日趋重要显示文摘在新冠肺炎疫情期间,中国采取的管制封锁措施大幅减少了交通和工业排放,但农业排放没有受到影响,甚至有所增加.通过全国大气氨浓度地面监测、实时连续观测和卫星观测等手段,我们发现,新冠肺炎疫情管制措施实施期间中国大气氨浓度大范围显著增加,上升幅度在农村地区最为明显(增加22%),在城市和偏远地区变化不明显;而且,管控期间大气氨浓度上升幅度与2015~2019年相同月份相比更大.基于大气化学模式模拟发现,中国北方大气氨浓度上升主要是由农业氨排放增加所致.随着未来我国二氧化硫和氮氧化物等酸性气体排放控制的强化,农业氨排放的协同减排对于进一步削减大气PM污染、提升空气质量尤为重要.进一步分析表明,疫情期间50%农业氨排放可有效抵消氨浓度上升造成的二次无机气溶胶的形成. | 许稳 赵园红 温章 常运华 潘月鹏 孙业乐 马昕 沙志鹏 李紫玥 康嘉慧 刘磊 唐傲寒 王锴 张颖 郭怡鑫 张霖 盛立芳 张秀明 谷保静 宋宇 Martin Van Damme Lieven Clarisse Pierre-Francois Coheur Jeffrey L.Collett Jr Keith Goulding 张福锁 贺克斌 刘学军 | 2022 | Science Bulletin2022，67，17： | 2 |
| 8 | Escherichia coli heat-stable toxin: its effect on motility of the small intestine显示文摘 | Mathias JR Nogueira J Martin JL | 1982 | Am J Physiol1982，242，2： | 1 |
| 9 | Virus - induced gene silencing in plants 显示文摘 | Lu R Martin - Hemandez AM Peart JR | 2003 | Methods2003，30，： | 1 |
| 10 | An overview of arsenic removal processes显示文摘 | KARTINEN E O Jr MARTIN C J | 1995 | Desalination1995，103，： | 1 |
| 11 | Understanding and managing HELLP syndrome : die integral role of aggressive glucocorticoids for mother and child 显示文摘 | Martin JN Jr Rose CH Briery CM | 2006 | Am J Obstet Gynecol2006，195，4： | 1 |
| 12 | The spectrum of severe preeclampsia: Comparative analysis by HELLP syndrome classification 显示文摘 | Martin JN Jr Rinehart B May WL | 1999 | Am J Obstet Gyneeol1999，180，： | 1 |
| 13 | Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infec- tion显示文摘 | Roncon-Albuquerque R Jr Pires I Martins R | 2009 | Neth J Med2009，67，2： | 1 |
| 14 | Standardized mississippi protocol treatment of 190 patients with HELLP syndrome: Slowing disease progression and preventing new major maternal morbidity显示文摘 | Martin JN Jr Owens MY Keiser SD | 2012 | Hypertens Pregnancy2012，31，1： | 1 |
| 15 | Angioplasty for long-term treatment of patients with Budd-Chiari syndrome 显示文摘 | Martin LG Henderson JM Millikan WJ Jr | 1990 | AJR Am J Roentgenol1990，154，5： | 1 |
| 16 | Clinical factors and prognosis in non-small cell lung cancer显示文摘 | Martins SJ Pereira JR | 1999 | Am J Clin Oncol1999，22，： | 1 |
| 17 | Record review of baboons with histologically confirmed endometriosis in a large established colony显示文摘 | Dick EJ Jr Hubbard GB Martin LJ | 2003 | J Med Primatol2003，32，： | 1 |
| 18 | Ceftriax-one-induced acute reversible encephalopathy in a patient treated for a urinary tract infection显示文摘 | Roncon-Albuquerque R Jr Pires I Martins R | | 0，，02： | 1 |
| 19 | Left atrial structure and function after percutaneous left atrial appendage lranscatheter occlusion ( PLAA- TO) Six- month echocardiographic follow- Up 显示文摘 | Hanna JR Kolm P Martin R | 2004 | J Am Coil Cardiol2004，43，： | 1 |
| 20 | Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress显示文摘 | Jenck F Moreau JL Martin JR | 1997 | Proc Natl Acad Sci USA1997，94，14： | 1 |
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