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| 1 | HIV自我检测的应用现状显示文摘HIV自我检测(自检)是扩大HIV防治重点人群检测覆盖面的一大重要措施和策略,具有巨大的应用价值,并在重点人群中有很高的接受性。WHO于2016年发布了《HIV自检和性伴通知指南》,支持在HIV检测服务中实施HIV自检,并为各国建立相应公共卫生政策提供具体指导,以改善HIV诊断的可及性和利用程度。在此策略的推动下,HIV自检已在许多国家和地区得到应用并取得了巨大的防治成效。为进一步推动HIV自检,提高重点人群的检测率,本文综述了目前国内外自检政策、干预模式、自检方法、自检试剂的准确性和自检前后的咨询服务方面的应用,旨在为进一步推动我国HIV自检工作提供参考依据。 | 包浣钰 熊媛 Gifty Marley 唐卫明 | 2021 | 中华流行病学杂志2021，42，2： | 11 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Persulfate oxidation for in situ remediation of TCE. I. Activated by ferrous ion with and without a persulfate–thiosulfate redox couple显示文摘 | Chenju Liang Clifford J. Bruell Michael C. Marley Kenneth L. Sperry | 2004 | Chemosphere2004，，9： | 2 |
| 4 | Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models显示文摘BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal diseases.Pharmacological studies report its anti-inflammatory,antioxidant,and antinociceptive activity.AIM To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial activity.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect.Muscarinic receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.The antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal agents.RESULTS(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation index.This activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or glibenclamide.In the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/mL.However,when it was associated with amphotericin B,no synergism was observed.CONCLUSION The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity. | Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 5 | Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions显示文摘Defects in craniofacial bones occur congenitally,after high-energy impacts,and during the course of treatment for stroke and cancer.These injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the injury.Significant inflammatory response after injury may greatly inhibit regenerative healing.We have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental proteins.The amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic inflammation.Herein,we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory cytokines.We report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose-derived stem cells within these scaffolds as a function of inflammatory challenge.Incorporation of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds,and increases in mineralized collagen-amnion scaffolds under inflammatory challenge.Together,these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair,especially in the course of defects presenting significant inflammatory complications. | Marley J.Dewey Eileen M.Johnson Simona T.Slater Derek J.Milner Matthew B.Wheeler Brendan A.C.Harley | 2020 | Regenerative Biomaterials2020，7，3： | 2 |
| 6 | Impacts of Typhoon ‘Koppu' on Infectious Diarrhea in Guangdong Province,China显示文摘This study aims to quantify the impact of typhoon ‘Koppu’ on infectious diarrhea in Guangdong, China in 2009. Rate ratios (RRs) were calculated by comparing person-time of infectious diarrhea cases between typhoon period and reference period. RRs of dysentery and other infectious diarrhea increased to a maximum of 1.12 (95% CI, 0.86-1.47), 1.10 (95% CI, 1.00-1.20) on the fifth lag day respectively. Children under 5 years were more vulnerable to infectious diarrhea, especially to other infectious diarrhea [RR: 1.21 (1.07-1.36) Vs. 1.03 (0.89-1.82)] after typhoon compared with people aged 〉5 years when RRs were at maximum. A mildly increased risk of infectious diarrhea was not only observed in great damaged regions, but also in other areas. | WANG Wei XUN Huan Miao ZHOU Mai Geng JIANG Bao Fa WANG Song Wang GUO Qing KANG Rui Hua WANG Xin Marley Gifty MA Wei | 2015 | Biomedical and Environmental Sciences2015，28，12： | 2 |
| 7 | On the utility of gambling: extending the approach of meginniss 显示文摘 | Ng C T Luce R D Marley A A J | 2008 | Aequationes Mathematicae2008，76，： | 1 |
| 8 | Persulfate oxidation for in situ remediation of TCE (Ⅰ) Activated by ferrous ion with and without a persulfate-thiosulfate redox couple 显示文摘 | Liang C Bruell C J Marley M C | 2004 | Chemosphere2004，55，： | 1 |
| 9 | Characterization of non-tuberculosis mycobacteria by neutron radiography 显示文摘 | Jaqueline MS Verginia RC Marlei GS | 2013 | Applied Radiation and Isotopes2013，77，1： | 1 |
| 10 | Utility of gambling I : entropy modified linear weighted utility 显示文摘 | Luce R D Ng C T Marley A A J | 2005 | Economic Theory2005，36，： | 1 |
| 11 | Pseudo-Meigs' Syndrome Due to Broad Ligament Leiomyoma:a Mimic of Metastatic Ovarian Carcinoma显示文摘 | Brown RS Marley JL Cassoni AM | 1998 | Clin Oncol (R Coll Radiol)1998，10，3： | 1 |
| 12 | High levels of Ep- stein-Ban' virus in COPD 显示文摘 | McManus TE Marley AM Baxter N | 2008 | Eur Respir J2008，31，6： | 1 |
| 13 | Utility of gambling II : risk, paradoxes, and data显示文摘 | Luce R D NgC T Marley A A J | 2008 | Economic Theory2008，36，： | 1 |
| 14 | Non-dermato- phytes in onychomycosis of the toenails 显示文摘 | Ellis DH Watson AB Marley JE Williams TG | 1997 | Br J Dermatol1997，136，4： | 1 |
| 15 | Primitive neuroectodermal tumorof the kidney-another enigma:a pathologic,immunohistochemical,and molecular diagnostic study显示文摘 | Marley EF Liapis H Humphrey PA | 1997 | Am J Surg Pathol1997，21，3： | 1 |
| 16 | Removing Volatile Contaminants from the Unsaturated Zone by Inducing Advective Air-Phase Transport显示文摘 | Baehr A L Hoag G E Marley M C | 1989 | Journal of Contaminant Hydrology1989，，4： | 1 |
| 17 | The first data from the Orion laser; measurements of the spectrum of hot, dense aluminium显示文摘 | D.J. Hoarty P. Allan S.F. James C.R.D. Brown L.M.R. Hobbs M.P. Hill J.W.O. Harris J. Morton M.G. Brookes R. Shepherd J. Dunn H. Chen E. Von Marley P. Beiersdorfer H.K. Chung R.W. Lee G. Brown J. Emig | 2013 | High Energy Density Physics2013，，4： | 1 |
| 18 | Thermallyactivated persulfate oxidation of trichloroethylene(TCE)and 1,1,1-trichloroethane(TCA)in aqueous systems andsoil slurries显示文摘 | Liang C J Bruell C J Marley M C Sperry K L | 2003 | Soil and Sediment Contamination2003，12，3： | 1 |
| 19 | Persulfate oxidation for in situ remediation of TCE (Ⅱ) Activated by chelated ferrous ion显示文摘 | Liang C Bruell C J Marley M C | 2004 | Chemosphere2004，55，： | 1 |
| 20 | Isokinetic strength characteristics in wrist flexion and extension显示文摘 | Marley RJ Thomson MR | | 0，，06： | 1 |
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