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| 1 | 卒中相关性肺炎的诊断卒中肺炎共识小组的推荐意见显示文摘背景和目的下呼吸道感染常并发于卒中并对转归造成不利影响。对于并发于卒中的下呼吸道感染性疾病,目前尚无公认的专业术语或诊断金标准,这导致临床诊疗和研究受到影响。本共识旨在提出急性卒中并发下呼吸道感染的标准化术语和可操作性诊断标准。方法对多个文献数据库进行系统检索,经过证据回顾和2轮讨论,最后于2014年9月在英国曼彻斯特召开共识会议,经75%以上共识小组成员达成一致意见后形成共识。结果达成的共识如下:(1)推荐使用卒中相关性肺炎(stroke-associated pneumonia, SAP )作为卒中发病后7 d内发生的下呼吸道感染性疾病的专业术语。(2)提议对 SAP 使用经过改良的美国疾病控制预防中心(Centers for Disease Control and Prevention, CDC)诊断标准:①很可能的 SAP:符合 CDC 诊断标准,但复查或动态监测胸部 X 片仍缺乏典型改变;②确诊的 SAP:符合 CDC 诊断标准,且胸部 X 片有典型改变。(3)关于白细胞计数或 C反应蛋白在 SAP 诊断中的作用证据有限。(4)其他生物学标记物(如降钙素原)的证据不足。结论提议根据 CDC 诊断标准对 SAP 的术语和诊断制定可操作性的共识标准,需要在卒中患者中进行前瞻性研究来确定其信度、效度以及对医生行为(包括抗生素选择)和临床转归的影响。 | Craig J. Smith Amit K Kishore Andy Vail Angel Chamorro Javier Garau Stephen J. Hopkins Mario Di Napoli Lalit Kalra Peter Langhorne Joan Montaner Christine Roffe Anthony G. Rudd Pippa J. TyrreU Diederik van de Peek Mark Woodhead Andreas Meisel 范琳琳 宿英英 | 2016 | 国际脑血管病杂志2016，24，2： | 17 |
| 2 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 3 | Sustainable Application of a Novel Water Cycle Using Seawater for Toilet Flushing显示文摘 | Xiaoming Liu Ji Dai Di Wu Feng Jiang Guanghao Chen Ho-Kwong Chui Mark C. M. van Loosdrecht | 2016 | Engineering2016，2，4： | 3 |
| 4 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 5 | c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target显示文摘 | Chenwei Li Jing–Jiang Wu Mark Hynes Joseph Dosch Bedabrata Sarkar Theodore H. Welling Marina Pasca di Magliano Diane M. Simeone | 2011 | Gastroenterology2011，，6： | 3 |
| 6 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 7 | Argon Plasma Coagulation Therapy Versus Topical Formalin for Intractable Rectal Bleeding and Anorectal Dysfunction After Radiation Therapy for Prostate Carcinoma显示文摘 | Eric Yeoh William Tam Mark Schoeman James Moore Michelle Thomas Rochelle Botten Addolorata Di Matteo | 2013 | International Journal of Radiation Oncology, Biol2013，，： | 3 |
| 8 | A randomized, controlled trial of oral sulfate solution plus polyethylene glycol as a bowel preparation for colonoscopy显示文摘 | Douglas K. Rex John McGowan Mark vB. Cleveland Jack A. Di Palma | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 9 | Evaluation of a 2D diode array for IMRT quality assurance显示文摘 | Daniel Létourneau Misbah Gulam Di Yan Mark Oldham John W. Wong | 2003 | Radiotherapy and Oncology2003，，2： | 2 |
| 10 | T-cell acute lymphoblastic leukemia in adults:clinical features,immunophenotype,cytogenetics,and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)显示文摘 | Marks DI Paietta EM Moorman AV | 2009 | Blood2009，114，25： | 1 |
| 11 | Recent developments in the management of T-cell precursor acute lymphoblastic leukemia/ lymphoma 显示文摘 | Fielding AK Banerjee L Marks DI | 2012 | Curr' Hematol Malig Rep2012，7，2： | 1 |
| 12 | T-cell acute lympho- blastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospec- tive trial (UKALL XII/ECOG 2993)显示文摘 | Marks DI Paietta EM Moorman AV | 2009 | Blood2009，114，25： | 1 |
| 13 | T-cell acute lymphoblastic leukemia in adults:clinical features,immunophenotype,cytogenetic,and outcome from the large randomized prospective trial (UKALL XII/ECOG2993) 显示文摘 | Marks DI Paietta EM Moorman AV | 2009 | Blood2009，114，25： | 1 |
| 14 | Voriconazole versus itraconazole for antifungal prophylaxis following allogeneic haematopoietic stem-cell transplantation 显示文摘 | Marks DI Pagliuca A Kibbler CC | 2011 | Br J Haematol2011，155，3： | 1 |
| 15 | The toxicity and efficacyof donor lymphocyte infusions given after reduced-intensity con-ditioning allogeneic stem cell transplantation显示文摘 | Marks DI Lush R Cavenagh J | 2002 | Blood2002，100，： | 1 |
| 16 | Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: Impact of tyrosine kinase inhibitor and minimal residual disease 显示文摘 | Bachanova V Marks DI Zhang MJ | 2014 | Leukemia2014，28，3： | 1 |
| 17 | A randomized clinical study comparing reduced-volume oral sulfate solution with standard 4-liter sulfate-free electrolyte lavage solution as preparation for colonoscopy显示文摘 | Douglas K. Rex Jack A. Di Palma Reynaldo Rodriguez John McGowan Mark Cleveland | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 18 | The outcome of full- intensity and reduced-intensity conditioning matched sibling or unrelated donor transplantation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first and second complete remission显示文摘 | Marks DI Wang T Perez WS | 2010 | Blood2010，116，3： | 1 |
| 19 | A comparison of cyclophosphamide and total body irradiation with etoposide and total body irradiation as conditioning regimens for patients undergoing sibling allografting for acute lymphoblastic leukemia in first or second complete remission显示文摘 | Marks DI Forman SJ Blume KG | 2006 | Biol Blood Marrow Transplant2006，12，4： | 1 |
| 20 | PC-SPES : herbal formulation for prostate cancer显示文摘 | Marks LS Di Paola RS Nelson P ct al | 2003 | Urology2003，61，6： | 1 |
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