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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 3 | Integrins显示文摘 | Richard O. Hynes | 2002 | Cell2002，，6： | 3 |
| 4 | 固体成型硫磺与块粉状硫磺性能的比较显示文摘介绍了在二次污染、酸化腐蚀、熔化能耗及安全性方面 ,固体成型硫磺与块粉状硫磺相比 。 | Hyne J B | 2001 | 硫酸工业2001，，2： | 3 |
| 5 | c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target显示文摘 | Chenwei Li Jing–Jiang Wu Mark Hynes Joseph Dosch Bedabrata Sarkar Theodore H. Welling Marina Pasca di Magliano Diane M. Simeone | 2011 | Gastroenterology2011，，6： | 3 |
| 6 | CH3SH photolysis at 248nm,hydrogen atom yield and rate constant for the H+CH3SH reaction 显示文摘 | WINE P H NICOVICH J M HYNES A J | 1986 | J Phys Chem1986，90，17： | 2 |
| 7 | Transformed mammalian cells secrete specific proteins and phosphoproteins显示文摘 | Senger DR Wirth DF Hynes RO | | 0，，04： | 2 |
| 8 | Water reorientation in the hydration shells of hydrophilic and hydrophobic solutes显示文摘We discuss some key aspects of our recent theoretical work on water reorientation dynamics,which is important in a wide range of phenomena,including aqueous phase chemical reactions,protein folding,and drug binding to proteins and DNA. It is shown that,contrary to the standard conception that these dynamics are diffusional,the reorientation of a water molecule occurs by sudden,large amplitude angular jumps. The mechanism involves the exchange of one hydrogen bond for another by the reorienting water,and the process can be fruitfully viewed as a chemical reaction. The results for reorientation times,which can be well described analytically,are discussed in the context of the molecular level interpretation of recent ultrafast infrared spectroscopic results,focusing on the concepts of structure making/breaking and solvent 'icebergs'. | LAAGE Damien STIRNEMANN Guillaume HYNES James T. | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 2 |
| 9 | Geneticmodification of liver grafts with an adenoviral vector encoding the Bcl-2 geneimproves organ preservation显示文摘 | Bilbao G Contreras JL Gomez Navarro J Eckhoff DE Mikheeva G Krasnykh V Hynes T Thomas FT Thomas JM Curiel DT | | 0，，： | 2 |
| 10 | Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis显示文摘 | Myriam Labelle Shahinoor Begum Richard O. Hynes | 2011 | Cancer Cell2011，，5： | 2 |
| 11 | Integrins: Verastility, modulation and signaling in cell adhesion显示文摘 | Hynes R O | 1992 | Cell1992，69，1： | 1 |
| 12 | Transformation speific secreted phosophoproteina 显示文摘 | Senger DR Wirth DF Hynes RO | 1980 | Nature1980，286，5773： | 1 |
| 13 | Effect of particulate materials and osmoprotectants on very-high-gravity ethanolic fermentation by Saccharomyces cerevisiae显示文摘 | Thomas K C Hynes S H Ingledew W M | 1994 | Applied and EnvironmentalMicrobiology1994，60，5： | 1 |
| 14 | Integrins:Versatility,modulation and signaling in cell adhesion显示文摘 | Hynes RO | 1992 | Cell1992，69，1： | 1 |
| 15 | Integrins:a family of cell suface receptors显示文摘 | Hynes RO | 1987 | Cell1987，48，： | 1 |
| 16 | Transformed mammalian cells secretspecific proteins and phosphoproteins显示文摘 | Senger DR Wirth DF Hynes RO | 1979 | Cell1979，16，4： | 1 |
| 17 | Developmental Defects in Mouse Embryos Lacking N-Cadherin显示文摘 | Glenn L. Radice Helen Rayburn Hiroaki Matsunami Karen A. Knudsen Masatoshi Takeichi Richard O. Hynes | 1997 | Developmental Biology1997，，1： | 1 |
| 18 | Out- comes of cataract surgery in children with chronic uveitis显示文摘 | Quinones K Cervantes-Castaneda R A Hynes A Y | 2009 | J Cataract Refract Surg2009，35，4： | 1 |
| 19 | Amphibians and agricultural chemicals:Review of the risks in a cmplex environment 显示文摘 | MANN R M HYNE R V CHOUNG C B | 2009 | Environ Pollut2009，157，11： | 1 |
| 20 | Nephronophthisis: a genetically diverse ciliopathy 显示文摘 | SIMMS R J HYNES A M ELEY L | 2011 | Int J Nephrol2011，2011，52： | 1 |
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