|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract显示文摘Organ fibrosis and architectural remodeling can severely disrupt tissue function,often with fatal consequences.Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli,and the key cellular mediator of fibrosis comprises the myofibroblasts which,when activated,serve as the primary collagen-producing cells.Complex links exist between fibrosis,regeneration and carcinogenesis,and the concept that all organs contain common tissue fibrosis pathways that could be potential therapeutic targets is an attractive one.Because of the major impact of fibrosis on human health there is an unmet need for safe and effective therapies that directly target fibrosis.Halofuginone inhibits tissue fibrosis and regeneration,and thereby affects the development of tumors in various tissues along the gastrointestinal tract.The high efficacy of halofuginone in reducing the fibrosis that affects tumor growth and tissue regeneration is probably due to its dual role in inhibiting the signaling pathway of transforming growth factorβ,on the one hand,and inhibiting the development of Th17 cells,on the other hand.At present halofuginone is being evaluated in a clinical trial for other fibrotic indication,and any clinical success in that trial would allow the use of halofuginone,also for all other fibrotic indications,including those of the gastrointestinal tract. | Mark Pines | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 2 | The chemistry and biology of febrifugine and halofuginone显示文摘 | Noel P. McLaughlin Paul Evans Mark Pines | 2014 | Bioorganic & Medicinal Chemistry2014，，： | 3 |
| 3 | Hydrodynamics based transfection in normal and fibrotic rats显示文摘AIM: Hydrodynamics based transfection (HBT), the injection of a large volume of naked plasmid DNA in a short time is a relatively simple, efficient and safe method for in vivo transfection of liver cells. Though used for quite some time, the mechanism of gene transfection has not yet been elucidated. METHODS: A luciferase encoding plasmid was injected using the hydrodynamics based procedure into normal and thioacetamide-induced fibrotic Sprague Dawley rats. Scanning and transmission electron microscopy images were taken. The consequence of a dual injection of Ringer solution and luciferase pDNA was followed. Halofuginone, an anti collagen type I inhibitor was used to reduce ECM load in fibrotic rats prior to the hydrodynamic injection. RESULTS: Large endothelial gaps formed as soon as 10’ following hydrodynamic injection; these gradually returned to normal 10 d post injection. Hydrodynamic administration of Ringer 10 or 30 m prior to moderate injection of plasmid did not result in efficient transfection suggesting that endothelial gaps by themselves are not sufficient for gene expression. Gene transfection following hydrodynamic injection in thioacetamide induced fibrotic rats was diminished coinciding with the level of fibrosis. Halofuginone, a specific collagen typeⅠ inhibitor, alleviated this effect. CONCLUSION: The hydrodynamic pressure formedfollowing HBT results in the formation of large endothelial gaps. These gaps, though important in the transfer of DNA molecules from the blood to the space of Disse are not enough to provide the appropriate conditions for hepatocyte transfection. Hydrodynamics based injection is applicable in fibrotic rats provided that ECM load is reduced. | Rita Yeikilis Shunit Gal Natalia Kopeiko Melia Paizi Mark Pines Filip Braet Gadi Spira | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 4 | Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism显示文摘 | Karen O. Yee Caitlin M. Connolly Mark Pines Jack Lawler | 2006 | Cancer Biology & Therapy2006，，： | 1 |
| 5 | Electrocardiographic manifestations of cardiac infectious-inflammatory disorders显示文摘 | Mohan Punja Dustin G. Mark Jonathan V. McCoy Ramin Javan Jesse M. Pines William Brady | 2010 | American Journal of Emergency Medicine2010，，3： | 1 |
| 6 | The detection of nontraumatic suharachnoid hemorrhage: still a diagnostic challenge 显示文摘 | Mark DG Pines JM | 2006 | Am J Emerg Meal2006，24，7： | 1 |
| 7 | Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats显示文摘 | Gadi Spira Nidal Mawasi Melia Paizi Natali Anbinder Olga Genina Rosaly Alexiev Mark Pines | 2002 | Journal of Hepatology2002，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员