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| 1 | Prunus genetics and applications after de novo genome sequencing:achievements and prospects显示文摘Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST resources.With public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits ensued.In this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome sequences.Within the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs worldwide.Functionally,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus traits.These include phenology,fruit quality,allergens,disease resistance,tree architecture,and self-incompatibility.Translationally,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop improvement.Finally,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry. | Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan Gao Ksenija Gasic Amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús | 2019 | Horticulture Research2019，6，1： | 8 |
| 2 | Effect of Calcineurin Inhibitors in the Outcome of Liver Transplantation in Hepatitis C Virus-Positive Recipients显示文摘 | Marina Berenguer Victoria Aguilera Fernando San Juan Salvador Benlloch Angel Rubin Rafael López-Andujar Angel Moya Eugenia Pareja Eva Montalva Maria Yago Manuel de Juan José Mir Martín Prieto | 2010 | Transplantation2010，，11： | 3 |
| 3 | Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases显示文摘试验性的证据建议了那血浆膜(下午) 联系了发信号并且类脂化合物作文和组织上的因此房间新陈代谢和 viabilitydepend。现在的工作的目的是开发一个房间模型学习丰满的酸(PUFA ) 在下午性质和分析上完成的 endogenouspolyunsaturated 它对胆固醇(Chol ) 的影响动态平衡。Wehave 以前由使用一根房间线显示出那细胞的小径由不同机制在 Chol 流出和房间生存能力包含了的过去表示的 stearoyl-CoA-desaturase,膜作文和 organizationcoordinate。现在,我们扩展了我们的 studiesto 一个房间模型过去表示 5 和 6 desaturases,它在下午导致了一个永久地更高的 PUFA 内容。而且,这根房间线显示出增加的下午流动性, Chol 存储,和 mitochondrial 活动。另外,人的 apolipoprotein A-I-mediatedChol 移动比在相应控制在这些房间是不太有效的。一起拿,我们的结果建议 thatthe 房间功能被调整下午组织和 Chol 出口和动态平衡保存。 | Maria S. Jaureguiberry M. Alejandra Tricerri Susana A. Sanchez Gabriela S. Finarelli Mauro A. Montanaro Eduardo D. Prieto Omar J. Rimoldi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 2 |
| 4 | Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021显示文摘The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this population.Therefore,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific societies.The present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and recommendations.While chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical difficulties.Furthermore,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with IBD.Nevertheless,further studies are warranted to define the optimal follow-up strategy in this patient population. | Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David Prieto Victor Garcia Javier Sempere | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 5 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 6 | Phylogeny,taxonomy and diversification events in the Caliciaceae显示文摘Although the high degree of non-monophyly and parallel evolution has long been acknowledged within the mazaediate Caliciaceae(Lecanoromycetes,Ascomycota),a natural re-classification of the group has not yet been accomplished.Here we constructed a multigene phylogeny of the Caliciaceae-Physciaceae clade in order to resolve the detailed relationships within the group,to propose a revised classification,and to perform a dating study.The few characters present in the available fossil and the complex character evolution of the group affects the interpretation of morphological traits and thus influences the assignment of the fossil to specific nodes in the phylogeny,when divergence time analyses are carried out.Alternative fossil assignments resulted in very different time estimates and the comparison with the analysis based on a secondary calibration demonstrates that the most likely placement of the fossil is close to a terminal node rather than a basal placement in the Calicium clade.Our dating analysis show two successive events giving rise to main clades of mazaediate taxa within the Caliciaceae,in the Upper-Lower Cretaceous boundary and in the Paleocene.As a result of this study,Cyphelium is synonymized with Calicium,Acolium is resurrected,and the new genera Allocalicium and Pseudothelomma are described.Twelve new combinations are proposed:Acolium karelicum,Acolium marcianum,Allocalicium adaequatum,Calicium carolinianum,Calicium lecideinum,Calicium lucidum,Calicium notarisii,Calicium pinicola,Calicium trachyliodes,Pseudothelomma occidentale,Pseudothelomma ocellatum and Thelomma brunneum.A key for the mazaedium-producing Caliciaceae is included. | Maria Prieto Mats Wedin | 2017 | Fungal Diversity2017，，1： | 2 |
| 7 | Matrix metalloproteinase‐10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair显示文摘 | Oihane Garcia‐Irigoyen Simone Carotti Maria U. Latasa Iker Uriarte Maite G. Fernández‐Barrena Maria Elizalde Raquel Urtasun Umberto Vespasiani‐Gentilucci Sergio Morini Jesús M. Banales William C. Parks Jose A. Rodriguez Josune Orbe Jesús Prieto Jose A. Pá | 2014 | Liver Int2014，，7： | 1 |
| 8 | Effects of wheat cultivar and nitrogen application on storage protein composition and breadmaking quality显示文摘 | Eva Johansson Maria Luisa Prieto - Linde Jan J Nsson | 2001 | Cereal Chemistry2001，78，1： | 1 |
| 9 | Burden of adult variceUa hospitalizations in Spain (2001 -2007) 显示文摘 | Jose Maria Guillen Ruth Gil- Prieto Alejandro Alvaro | 2010 | Human Vaccines2010，6，8： | 1 |
| 10 | Phylogeny andsystematics of Micranthes ( Saxifragaceae ) : an appraisal inEuropean territories 显示文摘 | Prieto J A Sanna M Maria A J | 2013 | J Plant Res2013，126，5： | 1 |
| 11 | Fungal pretreament: An alternative in second-generation ethanol from wheat straw显示文摘 | Davinia Salvachfa Alicia Prieto Maria L6pez-Abelairas | 2011 | Bioresource Technology2011，102，16： | 1 |
| 12 | Solubility in supercritical carbon dioxide of the predominant carotenes of tomato skin 显示文摘 | Gomez - Prieto M S Caja M M Santa - Maria G | 2002 | JAOCS2002，79，9： | 1 |
| 13 | Adherence to Lamivudine After an Early Withdrawal of Hepatitis B Immune Globulin Plays an Important Role in the Long-Term Prevention of Hepatitis B Virus Recurrence显示文摘 | Maria Buti Antoni Mas Martin Prieto Fernando Casafont Antonio González Manuel Miras Jose Ignacio Herrero Rosendo Jardi Rafael Esteban | 2007 | Transplantation2007，，5： | 1 |
| 14 | A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBlg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantationq显示文摘 | Maria Buti Antoni Mas Martin Prieto | 2003 | J Hepatology2003，38，： | 1 |
| 15 | Residential satisfaction, sense of belonging and loneliness among older adults living in the com- munity and in care facilities显示文摘 | Maria - Eugenia Prieto - Flores | 2011 | Health & Place2011，，6： | 1 |
| 16 | Sofosbuvir compassionate use program for patients with severe recurrent hepatitis C after liver transplantation显示文摘 | Xavier Forns Michael Charlton Jill Denning John G. McHutchison William T. Symonds Diana Brainard Theo Brandt‐Sarif Paul Chang Valerie Kivett Lluís Castells Martín Prieto Robert J. Fontana Thomas F. Baumert Audrey Coilly Maria Carlota Londo?o Fran?ois Habe | 2015 | Hepatology2015，，5： | 1 |
| 17 | Determination of protein markers in human serum:Analysis of protein expression in toxic oil syndrome studies显示文摘 | CARMEN QUERO NURIA COLOME MARIA ROSARIO PRIETO | 2004 | Proteomics2004，4，2： | 1 |
| 18 | Cobalt supported on morphologically tailored SBA-15 mesostructures: The impact of pore length on metal dispersion and catalytic activity in the Fischer–Tropsch synthesis显示文摘 | Gonzalo Prieto Agustín Martínez Raúl Murciano Maria A. Arribas | 2009 | Applied Catalysis A General2009，，1： | 1 |
| 19 | Blends of Isotactic Polypropylenes and a Plastomer: Crystallization and Viscoelastic Behavior 显示文摘 | Maria L Cerrada Qscar Prieto | 2003 | Macromol Syrup2003，，： | 1 |
| 20 | Early tacrolimus exposure does not impact long-term outcomes after liver transplantation显示文摘BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma recurrence.Nevertheless,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after LT.METHODS One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively studied.Patients with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction therapy.Patients were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient mortality.RESULTS Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,respectively.Donor age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across groups.After a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate analyses.CONCLUSION Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients. | Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Suárez Andres Valdivieso | 2021 | World Journal of Hepatology2021，13，3： | 0 |
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