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| 1 | Development of a tandem repeat-based multilocus typing system distinguishing Babesia bovis geographic isolates显示文摘 | Agustina Perez-Llaneza Marina Caballero Eugenia Baravalle Maria Mesplet Juan Mosqueda Carlos E. Suarez Ignacio Echaide Frank Katzer Gabriela M. Pacheco Monica Florin-Christensen Leonhard Schnittger | 2009 | Veterinary Parasitology2009，，2： | 1 |
| 2 | 北京大学附属中学扩建——体育馆和教学北楼显示文摘项目名称:北京大学附属中学体育馆及教学北楼精装修设计工程业主:北京大学附属中学设计单位:Crossboundaries,北京建设地点:北京市海淀区大泥湾中学设计面积:26 000 m2(建筑面积)设计范围:体育馆一期地上一层地下两层,教学北楼地上四层地下一层设计总负责:蓝冰可(Binke Lenhardt), | 无 蓝冰可 董灏 Sidonie Kade Irene Sola 汤佳音 Libny Pacheco Brecht van Acker Maria Francesca Origa 成思 Hugo Rios 陈彦哲 王旭东 王子凌(摄影) 杨超英(摄影) | 2017 | 城市建筑2017，0，16： | 1 |
| 3 | Anguilla anguilla L. oxidative stress biomarkers responses to copper exposure with or without β-naphthoflavone pre-exposure显示文摘 | Iqbal Ahmad Miguel Oliveira Mário Pacheco Maria Ana Santos | 2005 | Chemosphere2005，，2： | 1 |
| 4 | Production of structured lipids by aeidolysis with immobilized Rhizomucor miehei lipases: Selection of suitable reaction conditions显示文摘 | Camila A Palla Consuelo Pacheco Maria E Carrin | 2012 | Journal of Molecular Catalysis B: Enzymatic2012，76，： | 1 |
| 5 | Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America显示文摘BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent years.There is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing.Tuberculosis(TB)remains a public health problem,and it has a high incidence in several countries.Therefore,knowledge of the risk of developing TB in patients with IBD is important.AIM To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODS A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB development.RESULTS Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence.The TNFα blockers increased the relative risk of developing active TB compared to other treatments.All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB.After adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment.Late TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most frequent.CONCLUSION Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America.This risk was increased when anti-TNFα was combined with azathioprine.The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. | Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique CA Santos Claudia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 6 | Assessment of Genetic Stability Among In Vitro Plants of Arachis retusa Using RAPD and AFLP Markers for Germplasm Preservation显示文摘随机的放大多态的脱氧核糖核酸(RAPD ) 和采指纹的放大碎片长度多型性(AFLP ) 被用来评估从子叶和 A 的胚胎斧子发源的试管内植物的遗传稳定性。retusa。通过直接瀑形成和胚胎斧子的形成的射击多显示出的子叶射击 110.0 和 8.8 mmol BAP 导致的形成[本甲基腺嘌]/litre 分别地。AFLP 分析从 RAPD 和 372 lociobtained 产生的 90 个 genomic 区域(loci ) 被评估。两种技术在从二种将生物的活组织移植于培养基中培养类型导出的植物检测的所有放大碎片是 monomorphic。结果显示恢复射击在估计的 genomic 区域是遗传上稳定的…… | Rachel Fatima Gagliardi Luiz Ricardo Hanai Georgia Pacheco Carlos Alberto Oliveira Leonardo Alves Carneiro José Francisco Montenegro Valls Elisabeth Mansur Maria Lucia Carneiro Vieira | 2007 | Journal of Integrative Plant Biology2007，49，3： | 1 |
| 7 | Small peptides from enzymatic whey hydrolyzates increase dialyzable iron显示文摘 | Lucia de la Hoz Vera S. Nunes da Silva Marcelo Antonio Morgano Maria Teresa Bertoldo Pacheco | 2013 | International Dairy Journal2013，，： | 1 |
| 8 | Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday显示文摘Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking spec.nov.,C.applanata Moncada,Soto-Medina&Lücking spec.nov.,C.arachnodavidea Moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana Moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,Moncada&C.Vargas spec.nov.,C.auriculeslia Moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera Moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.Morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,Martins&Lucheta spec.nov.,C.casasolana Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis Moncada,M.Gut.&Lücking spec.nov.,C.celestinoa Moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca Moncada,R.-E.Pe´rez&Herrera-Camp.spec.nov.,C.corani Lücking,E.Morales&Dal Forno spec.nov.,C.corelleslia Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia Moncada,J.Molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas Plata&Perlmutter spec.nov.,C.dalehana Moncada,Madrin˜a´n&Lücking spec.nov.,C.davibogotana Lücking,Moncada&Coca spec.nov.,C.davicrinita Moncada,Madrin˜a´n&Lücking spec.nov.,C.davidia Moncada,L.Vargas&Lücking spec.nov.,C.dewisanti Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.dulcis Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.elephas Lücking,Moncada&L.Vargas spec.nov.,C.fuscodavidiana Lücking,Moncada&L.Vargas spec.nov.,C.garagoa Simijaca,Moncada&Lücking spec.nov.,C.gigantea Lücking,Moncada&Coca spec.nov.,C.gomeziana Dal Forno,Chaves&Lücking spec.nov.,C.guajalitensis Lücking,Robayo&Dal Forno spec.nov.,C.hafecesweorthensis Moncada,Lücking&R.Pela´ez spec.nov.,C.haledana Dal Forno,Chaves&Lücking spec.nov.,C.hawksworthiana Dal Forno,P.Nelson&Lücking spec.nov.,C.hochesuordensis Lücking,E.Morales&Dal Forno spec.nov.,C.hymenocarpa Lücking,Chaves&Lawrey spec.nov.,C.imi Lücking,Chaves&Lawrey spec.nov.,C.itabaiana Dal Forno,Aptroot&M.Ca´ceres spec.nov.,C.leslactuca nov.,C.maxima Wilk,Dal Forno&Lücking spec.nov.,C.minutula Lücking,Moncada&Ya´nez-Ayabaca spec.nov.,C.palaeotropica Weerakoon,Aptroot&Lücking spec.nov.,C.palustris Dal Forno,Chaves&Lücking spec.nov.,C.parabovei Dal Forno,Kukwa&Lücking spec.nov.,C.paraciferrii Lücking,Moncada&J.E.Hern.spec.nov.,C.paraminor Dal Forno,Chaves&Lücking spec.nov.,C.pastorum Moncada,Patin˜o&Lücking spec.nov.,C.pichinchensis Paredes,Jonitz&Dal Forno spec.nov.,C.pikynasa J.-M.Torres,Moncada&Lücking spec.nov.,C.pseudobovei Wilk,Dal Forno&Lücking spec.nov.,C.pseudocorani Lücking,E.Morales&Dal Forno spec.nov.,C.putumayensis L.J.Arias,Moncada&Lücking spec.nov.,C.quillacinga Moncada,F.Ortega&Lücking spec.nov.,C.rothesiorum Moncada,Madrin˜a´n&Lücking spec.nov.,C.rubrosanguinea Nugra,Moncada&Lücking spec.nov.,C.santacruzensis Dal Forno,Bungartz&Ya´nezAyabaca,spec.nov.,C.schizophylloides Moncada,C.Rodrı´guez&Lücking spec.nov.,C.smaragdina Lücking,Rivas Plata&Chaves spec.nov.,C.soredavidia Dal Forno,Marcelli&Lücking spec.nov.,C.subdavicrinita Moncada,J.Molina&Lücking spec.nov.,C.suturifera Nugra,Besal&Lücking spec.nov.,C.terrestris Dal Forno,Chaves&Lücking spec.nov.,C.terricoleslia Wilk,Dal Forno&Lücking spec.nov.,C.udebeceana Moncada,R.Pela´ez&Lücking,Moncada&R.Pela´ez spec.Lücking spec.nov.,C.urceolata Moncada,Coca&Lücking spec.nov.,C.verjonensis Lücking,Moncada&Dal Forno spec.nov.,C.viliewoa Lücking,Chaves&Soto-Medina spec.nov.,and C.yukiboa Mercado-Dı´az,Moncada&Lücking spec.nov.Furthermore,the taxonomic status of the recently described or recognized species C.arachnoidea,C.aspera,C.ciferrii,and C.reticulifera,is revised. | Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca Leidy Yasmín Vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-Marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey | 2017 | Fungal Diversity2017，，3： | 0 |
| 9 | Anti-commons: How tragedies happen—— Some cases and the evidences on fisheries显示文摘 | FILIPE, José Antó nio Candeias Bonito FERREIRA, Manuel Alberto M. COELHO, Manuel Francisco Pacheco PEDRO, Maria Isabel Craveiro | 2008 | China-USA Business Review2008，7，11： | 0 |
| 10 | Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity显示文摘BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier integrity.AIM To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced obesity.METHODS Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range hyperglycemia.Six weeks later,dextran sodium sulfate was given to induce colitis.In select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis onset.Endpoints included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier integrity.RESULTS In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease severity.Diabetes was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese mice.Each of these effects of diabetes in diet-induced obese mice was ameliorated by restoring normoglycemia.CONCLUSION In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of hyperglycemia.Hyperglycemia-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis severity.These findings suggest that effective diabetes management may decrease the clinical severity of IBD. | Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett | 2023 | World Journal of Gastroenterology2023，29，33： | 0 |
| 11 | Remodeling of the cell wall as a drought-tolerance mechanism of a soybean genotype revealed by global gene expression analysis显示文摘Drought stress is major abiotic stress that affects soybean production.Therefore,it is widely desirable that soybean becomes more tolerant to stress.To provide insights into regulatory mechanisms of the stress response,we compared the global gene expression profiles from leaves of two soybean genotypes that display different responses to water-deficit(BR 16 and Embrapa 48,drought-sensitive and droughttolerant,respectively).After the RNA-seq analysis,a total of 5335 down-regulated and 3170 up-regulated genes were identified in the BR16.On the other hand,the number of genes differentially expressed was markedly lower in the Embrapa 48,355 up-regulated and 471 down-regulated genes.However,induction and expression of protein kinases and transcription factors indicated signaling cascades involved in the drought tolerance.Overall,the results suggest that the metabolism of pectin is differently modulated in response to drought stress and may play a role in the soybean defense mechanism against drought.This occurs via an increase of the cell wall plasticity and crosslink,which contributed to a higher hydraulic conductance(Kf)and relative water content(RWC%).The drought-tolerance mechanism of the Embrapa 48 genotype involves remodeling of the cell wall and increase of the hydraulic conductance to the maintenance of cell turgor and metabolic processes,resulting in the highest leaf RWC,photosynthetic rate(A),transpiration(E)and carboxylation(A/Ci).Thus,we concluded that the cell wall adjustment under drought is important for a more efficient water use which promoted a more active photosynthetic metabolism,maintaining higher plant growth under drought stress. | Flaviane Silva Coutinho Juliano Mendonça Rodrigues Lucas Leal Lima Rosilene Oliveira Mesquita Paola Avelar Carpinetti João Paulo Batista Machado Camilo Elber Vital Pedro Marcus Vidigal Maria Eduarda Soares Ramos Mariana Rocha Maximiano Angela Mehta Maria Goreti Almeida Oliveira Elizabeth Pacheco Batista Fontes Humberto Josuéde Oliveira Ramos | 2021 | aBIOTECH2021，2，1： | 0 |
| 12 | Do protostellar fountains shape the regional core mass function?显示文摘The emerging massive binary system associated with AFGL 961 signifies the latest generation of massive star and cluster formation in the Rosette Molecular Complex. We present the detection of a compact cluster of dusty cores toward the AFGL 961 region based on continuum imaging at 1.3 mm by the Submillimeter Array. The binary components of AFGL 961 are associated with the most intensive millimeter emission cores or envelopes, confirming that they are indeed in an early stage of evolution. The other massive cores, however, are found to congregate in the close vicinity of the central high-mass protostellar binary. They have no apparent infrared counterparts and are, in particular, well aligned transverse to the bipolar molecular outflows originating from AFGL 961. This provides evidence for a likely triggered origin of the massive cores. All 40 individual cores with masses ranging between 0.6 and 15 M⊙ were detected above a 3 σ level of 3.6 mJy beam-1 (or0.4 M⊙ ), based on which we derive a total core mass of 107 M⊙ in the AFGL 961 region. As compared to the stellar initial mass function, a shallow slope of 1.8 is, however, derived from the best fit to the mass spectrum of the millimeter cores with a prestellar and/or protostellar origin. The flatter core mass distribution in the AFGL 961 region is attributed here to dynamic perturbations from the massive molecular outflows that originated from the massive protostellar binary, which may have altered the otherwise more quiescent conditions of core or star formation, enhanced the formation of more massive cores and, as a result, influenced the core mass distribution in its close vicinity. | Jin-Zeng Li Claudio Carlos Mallamaci Ricardo César Podest Eloy Actis Vicente Ya-Fang Huang Ana Maria Pacheco | 2013 | Research in Astronomy and Astrophysics2013，13，6： | 0 |
| 13 | Managing complexity: A problem of chaos in fisheries policy显示文摘 | Jose Antonio Candeias Bonito Filipe Manuel Alberto Martins Ferreira Manuel Francisco Pacheco Coelho Maria Isabel Cravelro Pedro | 2010 | China-USA Business Review2010，9，3： | 0 |
| 14 | The Antiproliferative and Pro-apoptotic Role of 2-aminoethyl dihydrogen Phosphate in Triple-negative Breast Tumor Cells显示文摘Antineoplastic phospholipids are a new class of antitumor agents.These molecules interact with the plasma membrane,changing numerous pathways that induce cell death,with high selectivity for cancer cells.A representative of this class of antineoplastic agents is 2-aminoethyl dihydrogen phosphate(2-AEH2P).It is present in high intracellular concentrations in various tissues and organelles with antitumor,antiproliferative and pro-apoptotic action.Therefore,4T1 triple-negative tumor cells were treated in different concentrations in order to assess the cytotoxic potential and its effects on the modulation of cell death pathways in association with the chemotherapeutic drug Paclitaxel.2-AEH2P promoted cytotoxicity in tumor cells and significant morphological changes,however,it did not cause these effects in normal cells.There was positive regulation of proteins involved in the intrinsic pathway of cell death by apoptosis and regulation of the phases of cell cycle progression.Furthermore,structural and distribution changes in mitochondria,as well as decreased cell density and regression of the cytoskeleton were observed.The 2-AEH2P demonstrated a modulatory potential of apoptotic pathways inducing cell death,being a new compound with antitumor properties. | Antenor Pereira Bonfim Neto Laertty Garcia de Sousa Cabral Thalles Anthony Duarte Oliveira JulioCarlstron Pacheco Monique Gonçalves Alves Mercedes Reyes Hernández Rosa Andreia Nogueira Laiso Durvanei Augusto Maria | 2021 | Journal of Pharmacy and Pharmacology2021，9，4： | 0 |
| 15 | In vitro differentiation capacity of human breastmilk stem cells:A systematic review显示文摘BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same origin.Although those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large quantities.This characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative diseases.AIM To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic review.METHODS The searched databases were PubMed,EMBASE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English language.All were in vitro studies for analysis of the'cell differentiation potential'in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“CANCER”and their respective synonyms,which were previously consulted according to medical subject heading terms.PRISMA 2009 guidelines were followed in this study.RESULTS A total of 315 titles and abstracts of articles were examined.From these,21 were in common with more than one database,leaving 294 articles for analysis.Of that total,five publications met the inclusion criteria.When analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their stemness.Those cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly expressed.Those cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligodendrocytes,astrocytes,and neurons as well hepatocytes,β-pancreatic cells,and cardiomyocytes.CONCLUSION Although the literature has been scarce,the pluripotentiality of these cells represents great potential for tissue engineering and cellular therapy.Further studies for safe clinical translation are needed. | Camila Maria Ribeiro Pacheco Priscila Elias Ferreira Claudia Sayuri Sacaki Luana Alves Tannous Idiberto Jose Zotarelli-Filho Luiz Cesar Guarita-Souza Katherine Athayde Teixeira de Carvalho | 2019 | World Journal of Stem Cells2019，11，11： | 0 |
| 16 | A self-employed taxpayer experimental study on trust,power,and tax compliance in eleven countries显示文摘The slippery slope framework explains tax compliance along two main dimensions,trust in authorities and power of authorities,which influence taxpayers’compliance attitudes.Through frequentist and Bayesian analyses,we investigated the framework’s assumptions on a sample of 2786 self-employed taxpayers from eleven post-communist and non-post-communist countries doing business in five economic branches.After using scenarios that experimentally manipulated trust and power,our results confirmed the framework’s assumptions regarding the attitudes of the self-employed taxpayers;trust and power fostered intended tax compliance and diminished tax evasion,trust boosted voluntary tax compliance,whereas power increased enforced tax compliance.Additionally,self-employed taxpayers from post-communist countries reported higher intended tax compliance and lower tax evasion than those from non-post-communist countries.Our results offer tax authorities insights into how trust and power may contribute to obtaining and maintaining high tax compliance levels amid global economic challenges,downturns,and increasing tax compliance costs. | Larissa M.Batrancea Anca Nichita Ruggero De Agostini Fabricio Batista Narcizo Denis Forte Samuel de Paiva Neves Mamede Ana Maria Roux-Cesar Bozhidar Nedev LeošVitek József Pántya Aidin Salamzadeh Eleanya K.Nduka Janusz Kudła Mateusz Kopyt Luis Pacheco Isabel Maldonado Nsubili Isaga Serkan Benk Tamer Budak | 2022 | Financial Innovation2022，8，1： | 0 |
| 17 | The Igarapé Weir decelerated transport of contaminated sediment in the Paraopeba River after the failure of the B1 tailings dam(Brumadinho)显示文摘The B1 dam of Corrego do Feijao Mine,owned by Vale,S.A.mining company and located on the Ferro-Carvao stream,collapsed and injected 2.8 Mm^(3)of clayey,silty,and sandy iron-and manganese-rich tailings into the Paraopeba River(Minas Gerais state,Brazil).The accident occurred on 25 January 2019 and the tailings have been co-transported with coarser natural sediment since then,being partly trapped in the Igarape Weir reservoir located on the Paraopeba River nearly 45 km downstream the injection point.The general purpose of the current study was to model suspended sediment transport in the vicinity of the Igarape Weir aiming to assess the concomitant barrier effect imposed by this structure.Specifically,the spatial distributions of suspended clay,silt,and very fine-grained sand fractions(CSS)of sediment were mapped around the Igarape Weir under low-flow(16 m^(3)/s)and high-flow(5 to 10,000 years return period stream discharge;699e2,699 m^(3)/s)regimes,using RiverFlow2D as the modelling tool.The concentrations of the various grain materials in the upstream and downstream sectors were quantified linking the barrier effect to concentration reductions in the direction of stream flow.It was also a study goal to calculate differences of iron and manganese concentrations in the sediment+tailings mixtures along the Paraopeba River.The study results showed reductions in the CSS between 6.6%and 18%,from upstream to downstream of the Igarape Weir,related with backwater effects,free and sub-merged hydraulic jumps,bank sedimentation in periods of high flow,and streambed sedimentation controlled by channel sinuosity and tailings density.These reductions were accompanied by drops in the concentrations of iron and manganese present in the clay and silt fractions,which varied between 6%and 42%under low flows and between 16%and 44%under high flows.Bank sedimentation was viewed as a potential threat to the riparian vegetation in the long-term.Dredging is the potentially most effective mitigation measure to help lead the Paraopeba River to a pre-rupture condition.The retention of sediment+tailings transported in suspension is less effective than the trapping of bedload sediment+tailings behind the Igarape weir.The efficacy of sediment trapping is expected to be larger for natural sediment because it is much coarser than the tailings.In that context,the simulations revealed for the low-flow period that 33.6%of the sediment deposition comprised suspended transport of natural sediment(thus,was comprised 66.4%of bedload transport),this proportion rose to 86.9%for mixtures of natural sediment+tailings,a result that did not differ much for the high-flow periods. | Daniela Patrícia Salgado Terencio Fernando Antonio Leal Pacheco Renato Farias do Valle Junior Mayte Maria Abreu Pires de Melo Silva Teresa Cristina Tarle Pissarra Marília Carvalho de Melo Carlos Alberto Valera Luís Filipe Sanches Fernandes | 2023 | International Journal of Sediment Research2023，38，5： | 0 |
| 18 | Evidences on adaptive mechanisms for cardiorespiratory diseases regarding extreme temperatures and air pollution:A comparative systematic review显示文摘The negative cardiorespiratory health outcomes due to extreme temperatures and air pollution are widely stud-ied,but knowledge about the effectiveness of the implementation of adaptive mechanisms remains unclear.The objective of this paper is to explore the evidence of adaptive mechanisms for cardiorespiratory diseases regard-ing extreme temperatures and air pollution by comparing the results of two systematic literature review(SLR)processes sharing the same initial research question but led by two research groups with different academic back-grounds working in the same multidisciplinary team.We start by presenting the methodological procedures and the results of the SLR triggered by the research group mainly composed by researchers with a background in ge-ography(named geographical strategy).We then compare these results with those achieved in the SLR led by the research group with a background in epidemiology(named epidemiological strategy).Both SLR were developed under the EU Horizon 2020 Project“EXHAUSTION”.The results showed:1)the lack of evidence regarding the effectiveness of adaptation measures,namely due to the limited number of studies about the topic,the prepon-derance of studies dedicated to heat extremes or the unbalance between different adaptation measures;2)that the choice of search terms in the geographical strategy,despite being more comprehensive at first sight,ended up retrieving less results,but it brought new studies that can complement the results of the epidemiological strategy.Therefore,it is suggested that to strengthen the empirical evidence of the effectiveness of adaptation measures,powerful multidisciplinary teams should work together in the preparation of SLR in topics of great complexity,such as the one presented in this paper. | Helena Madureira Maria Pacheco Carlos Sousa Ana Monteiro Francesca De’-Donato Manuela De-Sario | 2021 | Geography and Sustainability2021，2，3： | 0 |
| 19 | Genoprotection and metabolic benefits of marine macroalgae-Insights into the concept of functional foods through direct and indirect consumption显示文摘The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain underexplored.Hence,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal phytocompounds.Mice(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei test.Complementarily,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth performance.Macroalgae unequivocally protected against MMS-induced genotoxicity.The activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy balance.Genoprotection properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(viz.energy balance improvement)should not be disregarded.Overall,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional food.The possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations. | Ana Marques João Ferreira Ana Cerqueda-Pacheco Vitória Pereira Helena Abreu Rui Pereira Maria João Pires Fernanda Seixas Paula Oliveira Isabel Gaivão Mário Pacheco | 2022 | Food Bioscience2022，47，3： | 0 |
| 20 | Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent显示文摘Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 Mg alloys - AZ31, Mg-1Zn, Mg-1Y, pure Mg, and Mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as Mg(OH)_(2), MgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that Mg-1Zn and Mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;Mg-4Ag corroded faster than all the other four alloys,and Mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals. | Margarida Pacheco Ivo M.Aroso Joana M.Silva Sviatlana V.Lamaka Jan Bohlen Maria Nienaber Dietmar Letzig Estêvão Lima Alexandre A.Barros Rui L.Reis | 2023 | Journal of Magnesium and Alloys2023，11，11： | 0 |
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