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| 1 | Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases显示文摘Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal plant.It currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer properties.In addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand out.Furthermore,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in patients.Currently,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial effects.The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases.This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases. | Jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca Elena Salobrar-Garcia Maria D.Pinazo-Duran Jose M.Ramirez Juan J.Salazar | 2020 | Neural Regeneration Research2020，15，8： | 6 |
| 2 | Retinal microglial activation in glaucoma:evolution over time in a unilateral ocular hypertension model显示文摘Glaucoma is a neurodegenerative chronic pathology,characterized by the loss of retinal ganglion cells(RGC),which leads to an irreversible vision field loss.The increased intraocular pressure(IOP)constitutes its main risk factor.Nowadays,the main treatments for glaucoma are focused on decreasing IOP;nevertheless,the progression of the disease continues,despite IOP control.This fact shows the existence of other factors that could contribute to the advance of glaucomatous neurodegeneration.The early diagnostics,the use of neuroprotective therapies,and knowledge of the pathological processes are the major challenges associated with the management of this disease.Different pathogenic mechanisms have been proposed to be responsible for RGC death,including oxidative stress,mitochondrial dysfunction,glutamate excitotoxicity,and neuroinflammation(Casson et al.,2012). | JoséA.Fernández-Albarral Ana I.Ramírez Rosa de Hoz Juan J.Salazar | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 3 | 热流效应对场向电流确定的影响显示文摘给出了任意速度分布函数条件下复频率的介电函数和色散关系的求解方法.讨论了16矩近似条件下,场向热流对电子速度分布函数,介电函数实部与虚部,以及离子与电子谐振频率和阻尼率的影响,并与平衡态时麦克斯韦分布等离子体的计算结果进行了比较.忽略场向热流效应,正向电子漂移速度条件下,上行等离子线探测,会过高估计场向电流;负向电子漂移速度条件下,上行等离子线探测会过低估计场向电流.对上下行等离子线同时探测情况,忽略热流效应同样会过高估计场向电流. | 徐彬 吴健 Cesar La Hoz 吴振森 车海琴 薛昆 | 2009 | 空间科学学报2009，29，6： | 2 |
| 4 | Microwaves in organic synthesis,thermal and non-thermal microwave effects显示文摘 | De la Hoz A Diaz-Ortiz A Moreno A | 2005 | Chemical Society Review2005，34，2： | 1 |
| 5 | Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell显示文摘 | Katarína Kyselá Anatoly A. Philimonenko Vlada V. Philimonenko Ji?í Janá?ek Michal Kahle Pavel Hozák | 2005 | Histochemistry and Cell Biology2005，，5： | 1 |
| 6 | Estimating conjectural variations for electricity market models 显示文摘 | Lopez de Haro S Sanchez Martin P de la Hoz Ardiz J E | 2007 | European Journal of Operational Research2007，181，3： | 1 |
| 7 | Autoimmune thyroid disease in rheumatoid arthritis: a global perspective显示文摘 | Cordenas Rolddn J Amaya-Amaya J Castellanos-de la Hoz J | 2012 | Arthritis2012，2012，： | 1 |
| 8 | Validation of the Spanish version of the Rhinoconjunetivitis Quality of Life Questionnaire (RQLQ) 显示文摘 | Soler R de la Hoz B Badia X | 2004 | Rev Clin Esp2004，204，3： | 1 |
| 9 | The clinical and radiological characteristics and evolution of incidentally diagnosed pulmonary thromboembolism 显示文摘 | Guerola P Arenas Jim6nez J de la Hoz Rosa J | 2008 | Radiologia2008，50，3： | 1 |
| 10 | Immediate allergic reactions by polyethylene glycol 4000:two cases显示文摘 | Ant o n Giron e s M Roan Roan J de la Hoz B | 2008 | Allergol lmmunopathol (Madr)2008，36，2： | 1 |
| 11 | Application of flow chemistry the reduction of nitriles to aldehydes显示文摘 | Mu noz J M Alcdzar J Hoz A | 2011 | Tetrahedron Letters2011，52，46： | 1 |
| 12 | Improvement of the sensory properties of dry-fermented sausages by the addi- tion of free amino acids显示文摘 | Herranz B Hoz L Hierro E | 2005 | Food Chemistry2005，91，4： | 1 |
| 13 | Rheological behaviour of commercial cooked meat products evaluated by tensile test and texture profile analysis (TPA)显示文摘 | M. Dolores Romero de ávila M. Isabel Cambero Juan A. Ordó?ez Lorenzo de la Hoz Ana M. Herrero | 2014 | Meat Science2014，，： | 1 |
| 14 | Design and evaluation of a learning environment to effectively provide network security skills显示文摘 | Marsa-Maestre I de la Hoz E Gimenez-Guzman J M | 2013 | Computers&Education2013，，11： | 1 |
| 15 | Structural modifications of beta- laetoglobulin subjected to gamma radiation显示文摘 | de la HOZ L NETTO F M | 2008 | International Dairy Journal2008，18，12： | 1 |
| 16 | Flavour of heated milks:A review显示文摘 | Calvo M M Hoz L de la | 1992 | International Dairy Journal1992，，2： | 1 |
| 17 | Artesunate+ amodiaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum ma laria in the Colombian Pacific region: a noninferiority trial显示文摘 | Dela Hoz RF Porras RA Rico MA | 2012 | Rev Soc Bras Med Trop2012，45，6： | 1 |
| 18 | Effect of dietary limeed oil and a-tocopheml on selected properties of pig fat显示文摘 | D'Arrigo M Hoz L Lopez-Bote CJ | 2002 | Canadian Journal of Animal Science2002，82，： | 1 |
| 19 | Simple sequence repeat primers used in polymerase chain reaction amplifications to study genetic diversity in barley 显示文摘 | Sanehez de la Hoz M P Davila J A Loarce Y | 1995 | Genome1995，39，1： | 1 |
| 20 | The relations between disciplinary and pedagogical knowledge and the length of teaching experience of biology and geography teachers显示文摘 | Hoz R Y Tomer Tamir P | 1990 | Journal of Research in Science Teaching1990，，27： | 1 |
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