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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling显示文摘 | Aline R. Borges Emilene M. Becker Céline Lequeux Maria Goreti R. Vale Sergio L.C. Ferreira Bernhard Welz | 2011 | Spectrochimica Acta Part B: Atomic Spectroscopy2011，，7： | 3 |
| 4 | Evolutional profile of the esophageal varices after splenectomy associated with ligation of the left gastric vein and sclerotherapy in schistosomal portal hypertension显示文摘 | Luciano Becker Tognetti Laorcio Tenerio Ribeiro Maria do Carmo | 2013 | Arquivos Brasileiros De Cirurgia Digestiva2013，26，1： | 1 |
| 5 | Perfluorooctane surfactants in waste waters, the major source of river pollution显示文摘 | Anna Maria Becker Silke Gerstmann Hartmut Frank | 2008 | Chemosphere2008，，1： | 1 |
| 6 | Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population显示文摘 | Susanne Krause Gerald Reese Stefanie Randow Danila Zennaro Donato Quaratino Paola Palazzo Maria Antonietta Ciardiello Arnd Petersen Wolf-Meinhard Becker Adriano Mari | 2009 | The Journal of Allergy and Clinical Immunology2009，，4： | 1 |
| 7 | Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease显示文摘 | Maria Becker Vered Lavie Beka Solomon | 2007 | Proc Natl Acad Sci USA2007，104，5： | 1 |
| 8 | Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population显示文摘 | Susanne Krause Gerald Reese Stefanie Randow Danila Zennaro Donato Quaratino Paola Palazzo Maria Antonietta Ciardiello Arnd Petersen Wolf-Meinhard Becker Adriano Mari | 2009 | The Journal of Allergy and Clinical Immunology2009，，4： | 1 |
| 9 | Gene regulation by homeobox transcription factor Prox1 in murine hepatoblasts显示文摘 | Maria Papoutsi Jozsef Dudas Jürgen Becker Marco Tripodi Lennart Opitz Giuliano Ramadori J?rg Wilting | 2007 | Cell and Tissue Research2007，，2： | 1 |
| 10 | Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification显示文摘Seven new polyketides,termed veramycins,were isolated from a Streptomyces sp.from the Sanofi microbial strain collection along with their known congeners NFAT-133 and TM-123.Veramycin A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell line.Total syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide family.Our approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 epimer.Finally,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene inactivation.Based on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis. | Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker Maria A.Patras Mona-Katharina Bill Michael Kurz Luigi Toti Sven W.Görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer | 2022 | Organic Chemistry Frontiers2022，9，6： | 1 |
| 11 | Current and Future Issues in BPM Research:A European Perspective from the ERCIS Meeting 2010 显示文摘 | Jan vom Brocke Jorg Becker Jorg Becker Alessio Maria Braccini | 2011 | Communications of the Association for Information Systems2011，25，28： | 1 |
| 12 | Completion Mucosectomy for Retained Rectal Mucosa Following Restorative Proctocolectomy with Double-Stapled Ileal Pouch–Anal Anastomosis显示文摘 | Maria E. Litzendorf Arthur F. Stucchi Susana Wishnia Amy Lightner James M. Becker | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 1 |
| 13 | In Vitro Antibacterial Potential of Plant Extracts and in Vivo Ilex paraguariensis Effect on Oreochromis niloticus Physiology and Resistance to Aeromonas hydrophila显示文摘The aim of the study was to investigate the antibacterial potential of garlic(Allium sativum),pinus(Pinus elliottii),eucalyptus(Eucalyptus sp.),yerba mate(Ilex paraguariensis)and guava tree(Psidium guajava Linn.)in vitro and the effect of yerba mate supplementation on Oreochromis niloticus physiology and resistance to Aeromonas hydrophila.The in vitro antibacterial potential of the plants was verified by the minimum inhibitory concentration(MIC)method and by the antimicrobial sensitivity test(TSA).The in vivo assay was performed using diet supplementation with yerba mate and challenge with A.hydrophila.After the supplementation and challenge periods biochemical,immune and physiological parameters were evaluated.The in vitro assays showed that only yerba mate presented antibacterial potential against A.hydrophila and no one of the plant extracts were effective against Streptococcus agalactiae.The use of yerba mate in the diet did not influence the immune and metabolic status of O.niloticus.Also,the supplementation did not act as a growth promoter for the fishes.Considering the challenge of O.niloticus with A.hydrophila,the yerba mate did not improve the resistance of the fishes to the bacteria.The yerba mate extract presented potential to be used as an antibacterial agent for fish diseases.Also,more detailed studies are necessary to stablish effective doses and times required for fish treatments. | Micheli Becker Maria Alice Nunes Vanessa Gomes da Silva Carlos Jose Raupp Ramos Silvia Romao Luciano Tormen Luisa Helena Cazarolli | 2018 | Journal of Agricultural Science and Technology(B)2018，8，7： | 0 |
| 14 | Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials’ resistance显示文摘To reduce the burden of denture stomatitis and oral candidiasis,an aqueous solution containing polyhexamethylene guanidine hydrochloride(PHMGH)was investigated as an antifungal disinfectant against the leading cause of these oral conditions,Candida albicans.The solutions formulated with concentrations ranging from 0.125 to 0.50 wt%enabled increasing disinfection at the initial 5min-contact with 72h-mature candida biofilms formed on denture liner specimens.After 10 min-contact,the solution at lower concentration has reached total fungal elimination.The results also indicated that the denture liners preserved their mechanical property after the maximum contact time with the solution at the highest tested concentration.The PHMGH aqueous solutions at 0.125 wt%could be applied to promote interim denture liner disinfection without promoting the loss of materials’mechanical property. | Isadora Martini Garcia Stéfani Becker Rodrigues Maria Eduarda Rodrigues Gama Vicente Castelo Branco Leitune Mary Anne Melo Fabrício Mezzomo Collares | 2020 | Bioactive Materials2020，5，2： | 0 |
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