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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Parallel arrays of Schottky barrier nanowire field effect transistors: Nanoscopic effects for macroscopic current output显示文摘我们由对有能力的自底向上的成年的硅 nanowires 的一个平行数组组成的现在的新奇 Schottky 障碍领域效果晶体管交付高当前的产量。nanowires 的轴的 silicidation 被用来创造导致多达 106 的开/关水流比率的定义 Schottky 连接。设备概念利用 nanoscale 连接的唯一的运输性质为宏观的应用程序增加设备性能。用平行数组,在 0.5 V 的来源排水管电压的超过 500 A 的在水流上能被完成。当维持单个 nanowire 设备的转移特征时,跨导因此显著地被增加。由把几百 nanowires 合并到平行数组,工作晶体管的收益戏剧性地被增加, deviceto 设备可变性与单个设备相比被减少。这个新 nanowirebased 平台提供足够的当前的输出为器官的轻射出的二极管(LEDs ) 为生物传感器或一个开车阶段作为一个变换器被采用,当制造过程的自底向上的性质意味着它能为新奇可印刷的电子设备提供积木时。 | Sebastian Pregl Walter M. Weber Daijiro Nozaki Jens Kunstmann Larysa Baraban Joerg Opitz Thomas Mikolajick Gianaurelio Cuniberti | 2013 | Nano Research2013，6，6： | 3 |
| 3 | Bottom-up synthesis of ultrathin straight platinum nanowires: Electric field impact显示文摘我们在场电气化学地成年的 ultrathin 上的电场效果的研究,有在测微计范围的 15 nm 和长度的最小的直径的直铂 nanowires,在 H2PtCl6 在在金属电极之间的硅氧化物底层上综合了答案。platinumcontaining 酸和 nanowires 的直径上的应用电压的频率的集中的影响与相应理论分析被讨论。,我们由金属电极的特定的几何学第一次证明电场介绍,戏剧性地影响 nanowires 的生长和形态学。最后,我们为控制制造提供指南,消除分叉并且联系直, ultrathin 金属电线并且树枝状的生长,它是当前的自底向上的纳米技术的主要缺点之一。建议概念薄 nanowires 自己组装,由电场影响了,潜在地经由电极几何学的聪明的设计为指导 nanocontacting 代表一条新线路。从 nanoelectronics 的可能的应用活动范围到煤气的传感器和生物传感器。 | Alexander Nerowski Joerg Opitz Larysa Baraban Gianaurelio Cuniberti | 2013 | Nano Research2013，6，5： | 3 |
| 4 | Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension显示文摘 | Wensel R Opitz CF Ewert R | 2000 | Circulation2000，101，20： | 1 |
| 5 | Tissue engineering of aortic tissue:dire consequence of suboptimal elastic fiber synthesis in vivo显示文摘 | Opitz F Schenke-Layland K Cohnert TU | 2004 | Cardiovasc Res2004，63，4： | 1 |
| 6 | Estimation of shear stress-related blood damage in heart valve prostheses-in vitro comparison of 25 aortic valves显示文摘 | Giersiepen M Wurzinger L J Opitz R | 1990 | Artif Organs1990，13，： | 1 |
| 7 | Stable mossy fi- ber long-term potentiation requires calcium influx at the granule cell soma, protein synthesis, and microtubule-de- pendent axonal transport 显示文摘 | Barnes S J Opitz T Merkens M | 2010 | The Journal of Neuro- science2010，30，12： | 1 |
| 8 | Prefrontal cortex involvement in preattentive auditory deviance detection: neuroimaging and electrophysiological evidence显示文摘 | Doeller CF Opitz B Mecklinger A | 2003 | Neuroimage2003，20，2： | 1 |
| 9 | Quantitative pro- moter methylation analysis of hepatccellular carcinoma, cirrhotic and normal liver显示文摘 | Harder J Opitz OG Brabender J | 2008 | Int J Cancer2008，122，12： | 1 |
| 10 | Systemic sclerosis - a systematic overview: part 2 - immunosuppression, treatment of SSc - associated vasculopathy, and treatment of pulmonary arterial hyperten- sion 显示文摘 | Opitz C Klein- Weigel PF Riemekasten G | 2011 | Vasa2011，40，1： | 1 |
| 11 | Display of functional thrombin inhibitor hirudin on the surface of phage M13 显示文摘 | Wirsching F Opitz T Dietrich R | 1997 | Gene1997，204，12： | 1 |
| 12 | Popular ensemble methods:an empirical study显示文摘 | OPITZ D MACLIN R | 1999 | Journal of Artificial IntelligenceResearch1999，11，1： | 1 |
| 13 | Activation in vagal afferents and central autonomic pathways:early responses to intestinal infection with Campylobacter jejuni显示文摘 | Goehler L E Gaykema R P Opitz N | 2005 | Brain Behav Immun2005，19，4： | 1 |
| 14 | Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R显示文摘 | Opitz CA Litzenburger UM Lutz C | 2009 | Stem Cells2009，27，4： | 1 |
| 15 | mGluRl-media- ted potentiation of NMDA receptors involves a rise in in- traceUular calcium and activation of protein kinase C 显示文摘 | Skeberdis V A Lan J Opitz T | 2001 | Neuropharmacology2001，40，： | 1 |
| 16 | Assessment of survival in patients with primary pulmonary hypertension: importance of cardiopulmonary exercise testing 显示文摘 | Wensel R Opitz CF Anker SD | 2002 | Circulation2002，106，： | 1 |
| 17 | Luteinizing hormone, follicle stimulating hormone, and gonadotropin releasinghormone mRNA expression of Xenopus laevis in response to endocrine disrupting compounds affecting reproductivebiology显示文摘 | Urbatzka R Lutz I Opitz R | 2006 | Gen Comp Endocrinol2006，146，2： | 1 |
| 18 | NOSTRIN:a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase显示文摘 | Zimmermann K Opitz N Dedio J | | 0，，： | 1 |
| 19 | Estimation of shear stress related blood damage in heart valve prostheses in vitro comparison of 25 aortic valves 显示文摘 | Giersiepen M Wurzinger L J Opitz R el al | 1990 | Int J Artif Organs1990，13，5： | 1 |
| 20 | Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae显示文摘 | Opitz B Puschel A Schmeck B | 2004 | J Biol Chem2004，279，36： | 1 |
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