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| 1 | Chronic effects induced by ibuprofen on the freshwater bivalve Dreissena polymorpha显示文摘 | Marco Parolini Andrea Binelli Alfredo Provini | 2011 | Ecotoxicology and Environmental Safety2011，，6： | 1 |
| 2 | Yolk vitamin E positively affects prenatal growth but not oxidative status in yellow-legged gull embryos显示文摘 | Marco PAROLINI Cristina Daniela POSSENTI Filiz KARADAS Graziano COLOMBO Maria ROMANO Manuela CAPRIOLI Isabella DALLE-DONNE Diego RUBOLINI Aldo MILZANI Nicola SAINO | 2018 | Current Zoology2018，64，3： | 1 |
| 3 | Perinatal variation and covariation of oxidative status and telomere length in yellow-legged gull chicks显示文摘The perinatal period is critical to survival and performance of many organisms.In birds,rapid postnatal growth and sudden exposure to aerial oxygen around hatching markedly affect the chick redox status,with potentially negative consequences on physiology mediated by oxidative stress.In addition,telomere length(TL)undergoes reduction during birds’early life,partly depending on oxidative status.However,relatively few studies have focused specifically on the changes in oxidative status and TL that occur immediately after hatching.In this study of the yellow-legged gull Larus michahellis,we found that chicks undergo a marked increase in plasma total antioxidant capacity and a marked decrease in the concentration of pro-oxidant molecules during the first days after hatching.In addition,TL in erythrocytes decreased by 1 standard deviation over the 4days post-hatching.Body mass and tarsus length covaried with total antioxidant capacity and concentration of pro-oxidants in a complex way,that partly depended on sex and laying order,suggesting that oxidative status can affect growth.Moreover,TL positively covaried with the concentration of pro-oxidant molecules,possibly because retention of high concentrations of pro-oxidant molecules results from mechanisms of prevention of their negative effects,including reduction in TL.Thus,this study shows that chicks undergo marked variation in oxidative status,which predicts growth and subsequent TL,prompting for more studies of the perinatal changes in the critical posthatching stages. | Marco PAROLINI Cristina Daniela POSSENTI Andrea ROMANO Manuela CAPRIOLI Diego RUBOLINI Nicola SAINO | 2019 | Current Zoology2019，65，5： | 1 |
| 4 | A case for assessment of oscillatory breathing during cardiopulmonary exercise test in risk stratification of elderly patients with chronic heart failure显示文摘 | Angela Beatrice Scardovi Renata De Maria Alessandro Ferraironi Laura Gatto Andrea Celestini Silvia Forte Marina Parolini Sebastiano Sciarretta Roberto Ricci Marco Guazzi | 2011 | International Journal of Cardiology2011，，： | 1 |
| 5 | Polybrominated Diphenyl Ether Contamination in Soil, Vegetation, and Cow Milk From a High-Mountain Pasture in the Italian Alps显示文摘 | Marco Parolini Niccolò Guazzoni Andrea Binelli Paolo Tremolada | 2012 | Archives of Environmental Contamination and Toxicology2012，，1： | 1 |
| 6 | Predation risk affects egg mass but not egg steroid hormone concentrations in yellow-legged gulls显示文摘Predators have both direct, consumptive effects on their prey and non-lethal effects on physiology and behavior, including reproductive decisions, with cascading effects on prey ecology and evol tion. Here, we experime ntally tested such non-lethal effects of exposure to in creased predati on risk on clutch size, egg mass, and the concentration of yolk steroid hormones in the yellow-legged gull Larus michahellis. We simulated increased predation risk by displaying stuffed predators (adult fox Vulpes vulpes, and adult buzzard Buteo buteo) to breeding adults before egg laying. The concentration of corticosterone, which has bee n show n to in crease un der exposure to mater nal predati on risk in other species, and of testosterone did not differ between eggs from mothers exposed to the predators and eggs from control mothers (i.e., eggs exposed to a novel object of similar size and position to the stuffed predators). The concentration of the two hormones negatively covaried. Clutch size did not vary according to experimental treatment, whereas egg mass was markedly larger in clutches from n ests exposed to predators than in clutches from control n ests. By in creasing egg mass, mothers may reduce the risk of cooling of the eggs when incubation is impeded by predators, boost energy reserves, reduce post-natal detectability caused by food solicitation, and/ or enha nee developme nt at hatchi ng, thus increasing the cha nces of offspri ng survival. In general, our results are inconsistent with most of the few previous studies on similar non-lethal predator effects and suggest that such effects may vary among species according to ecological conditions, social behavior, and developmental mode. | Cristina Daniela Possenti Alexandra Bea Bentz Andrea Romano Marco Parolini Manuela Caprioli Diego Rubolini Kristen Navara Nicola Saino | 2019 | Current Zoology2019，65，4： | 0 |
| 7 | Telomere shortening is associated with corticosterone stress response in adult barn swallows显示文摘When vertebrates face stressful events,the hypothalamic–pituitary–adrenal(HPA)axis is activated,generating a rapid increase in circulating glucocorticoid(GC)stress hormones followed by a return to baseline levels.However,repeated activation of HPA axis may lead to increase in oxidative stress.One target of oxidative stress is telomeres,nucleoprotein complexes at the end of chromosomes that shorten at each cell division.The susceptibility of telomeres to oxidizing molecules has led to the hypothesis that increased GC levels boost telomere shortening,but studies on this link are scanty.We studied if,in barn swallows Hirundo rustica,changes in adult erythrocyte telomere length between 2 consecutive breeding seasons are related to corticosterone(CORT)(the main avian GC)stress response induced by a standard capture-restraint protocol.Within-individual telomere length did not significantly change between consecutive breeding seasons.Second-year individuals showed the highest increase in circulating CORT concentrations following restraint.Moreover,we found a decline in female stress response along the breeding season.In addition,telomere shortening covaried with the stress response:a delayed activation of the negative feedback loop terminating the stress response was associated with greater telomere attrition.Hence,among-individual variation in stress response may affect telomere dynamics. | Alessandra COSTANZO Roberto AMBROSINI Marco PAROLINI Manuela CAPRIOLI Simona SECOMANDI Diego RUBOLINI Leonida FUSANI Virginie CANOINE | 2022 | Current Zoology2022，68，1： | 0 |
| 8 | Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out:An application to the Italian scenario显示文摘In the context of SARS-CoV-2 pandemic,mathematical modelling has played a funda-mental role for making forecasts,simulating scenarios and evaluating the impact of pre-ventive political,social and pharmaceutical measures.Optimal control theory represents a useful mathematical tool to plan the vaccination campaign aimed at eradicating the pandemic as fast as possible.The aim of this work is to explore the optimal prioritisation order for planning vaccination campaigns able to achieve specific goals,as the reduction of the amount of infected,deceased and hospitalized in a given time frame,among age classes.For this purpose,we introduce an age stratified SIR-like epidemic compartmental model settled in an abstract framework for modelling two-doses vaccination campaigns and conceived with the description of COVID19 disease.Compared to other recent works,our model incorporates all stages of the COVID-19 disease,including death or recovery,without accounting for additional specific compartments that would increase computa-tional complexity and that are not relevant for our purposes.Moreover,we introduce an optimal control framework where the model is the state problem while the vaccine doses administered are the control variables.An extensive campaign of numerical tests,featured in the Italian scenario and calibrated on available data from Dipartimento di Protezione Civile Italiana,proves that the presented framework can be a valuable tool to support the planning of vaccination campaigns.Indeed,in each considered scenario,our optimization framework guarantees noticeable improvements in terms of reducing deceased,infected or hospitalized individuals with respect to the baseline vaccination policy. | Giovanni Ziarelli Luca Dede’ Nicola Parolini Marco Verani Alfio Quarteroni | 2023 | Infectious Disease Modelling2023，8，3： | 0 |
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