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| 1 | Frequent mtDNA mutations and its role in gastric carcino-genesis显示文摘In order to disclose the relationship between mutations of mitochondrial DNA (mtDNA) and gastric car-cinogenesis, we screened the entire mtDNA sequence in 30 cases of human gastric cancer and matched normal tissues by using denaturing high-performance liquid chromatogra-phy (DHPLC) and DNA sequencing. Our data showed that high frequency (66.7%, 20/30) of mitochondrial genome mutation occurred in gastric cancer. Among these variants, 17 cases (56.7%, 17/30) were identified to be somatic mutation. High level mutant frequency was found in ND4, ND5 coding genes and D-loop control region, which was 36.7%, 26.7% and 30% respectively. Comparing with complexes Ⅲ, Ⅳ and V of the electron transport chain, we found that variants appeared to be more frequent in the subunit genes of complex I. Most of mutations were base substitutions (85.4%, 41/48). Our results suggested that mutations of subunit genes encoding complex I, especially MM, ND4 and ND5 genes, might contribute to human gastric carcinogenesis. | Manran Liu Youyong Lu | 2002 | Chinese Science Bulletin2002，47，20： | 2 |
| 2 | Paraffin/porous graphite matrixcomposite as a hish and constant power thermal stor- age material显示文摘 | PY X OFIVES S MANRAN S | 2001 | International Journal of Heat Mass Transfer2001，44，： | 1 |
| 3 | GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells显示文摘 | Tenghua Yu Manran Liu Haojun Luo Chengyi Wu Xi Tang Shifu Tang Ping Hu Yuzhao Yan Zhiliang Wang Gang Tu | 2014 | Journal of Steroid Biochemistry and Molecular Biology2014，，： | 1 |
| 4 | Immnnomodulatary effects of polysaccharopeptide ( PSP ) in human PBMC through regulation ff TRAF6/TLR immunosignal-transduction palhways 显示文摘 | Wenwen Li Manran Liu Sihan Lai | 2010 | Immunopharmacology and Immunotoxicology2010，32，4： | 1 |
| 5 | Nuclear factor-kB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo显示文摘 | Manran Liu Xiaoming Ju Nicole E Willmarth | 2009 | Am J Pathol2009，174，： | 1 |
| 6 | Facile preparation of^(177)Lu-microspheres for hepatocellular carcinoma radioisotope therapy显示文摘As one of the most common cancers in the world,hepatocellular carcinoma(HCC)has become a major threat to human health.Radioembolization is a first-line option for the treatment of HCC,especially when other conventional treatments fail or there exist some relative contraindications.Herein,we developed a facile and efficient method for preparing ^(177)Lu-microspheres potentially useful for precise radioembolization therapy of HCC.The radiolabeling efficiency of ^(177)Lu-microspheres was as high as 96.8%±0.5%,and the radiolabeling process did not alter the morphology of the mother microspheres.The SPECT/CT studies enabled by the unique emissions of ^(177)Lu suggested that almost no ^(177)Lu ion loaded by the microspheres was released over more than 32 d in vivo,which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice.The current approach may thus offer promising ^(177)Lu-microspheres for clinical radioembolization of HCC. | Manran Wu Kexin Shi Ruizhe Huang Chunyi Liu Lingling Yin Weipeng Yong Jing Sun Guanglin Wang Zhiyuan Zhong Mingyuan Gao | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
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