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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 3 | Photocatalytic Degradation of Dyes in Water:Case Study of Indigo and of Indigo Ocarmine显示文摘 | Manon V Guillard C Jean M H | 2001 | J Catal2001，201，1： | 1 |
| 4 | ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis显示文摘 | Pereira C Camougrand N Manon S | 2007 | Mol Microbiol2007，66，3： | 1 |
| 5 | Performance/structure correlation for composite SOFC cathodes显示文摘 | Juhl M Primdahl S Manon C | 1996 | J Power Souces1996，61，12： | 1 |
| 6 | Sagittal plane analysis of the spine and pelvis in adolescent idiopathic scoliosis according to the coronal curve type显示文摘 | Jean-Marc MT Hubert L Manon C | 2003 | Spine2003，28，13： | 1 |
| 7 | ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis显示文摘 | Pereira C Camougrand N Manon S | 2007 | Mol Microbiol2007，66，3： | 1 |
| 8 | Dihydrophenazine derivatives for overcharge protection of rechargeable lithium batteries显示文摘 | FRANCOIS T V MANON P YVES C | 1999 | Electrochimica Acta1999，44，： | 1 |
| 9 | Supercritieal fractional extraction of fennel seedoil and essential 0il:Experiments and mathematical modeling显示文摘 | REVERCHON E DAGHERO J MANONE C | 1999 | Ind Eng ChemRes1999，38，8： | 1 |
| 10 | ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome C release in yeast apoptosis显示文摘 | Pereira C Camougrand N Manon S | 2007 | Mol Microbiol2007，66，3： | 1 |
| 11 | Bioavailability of metformin in tablet form using a new high pressure liquid chromatography assay method显示文摘 | Gilles C Yves L Manon R | 1993 | Biopharmaceu Drug Dispo1993，114，： | 1 |
| 12 | ADP/ATP carrieris required for mitochondrial outer membrane permeabilization and cyto-chrome c release in yeast apoptosis显示文摘 | PEREIRA C CAMOUGRAND N MANON S | 2007 | Molecular Miobiology2007，66，3： | 1 |
| 13 | Optimal control of hybrid dynamical systems:application in process engineering显示文摘 | Manon P Valentin-Roubinet C Gilles G | 1998 | Control Engineering Practice1998，10，2： | 1 |
| 14 | Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy显示文摘 | Céline Schmitt Manon Voegelin Aurélie Marin Marjorie Schmitt Fabienne Schegg Philippe Hénon Dominique Guenot Céline Tarnus | 2013 | Bioorganic & Medicinal Chemistry2013，，7： | 1 |
| 15 | Antiangiogenic activity of paclitexal is associated with its cytostatic effect,mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway显示文摘 | Eddy P Manon C Bertrand P | | 0，，10： | 1 |
| 16 | Antiangiogenic activity of paclitexal is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway显示文摘 | Edd P Manon C Bertrand P | 2004 | Mol Cancer Ther October2004，3，10： | 1 |
| 17 | Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas显示文摘BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important aspect.Knowledge of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)lesions.AIM To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 SD-CRCs.Molecular analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)mutations.APC mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in SD-CRCs.This indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs. | Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee Manon van Engeland Manon C W Spaander Gerrit A Meijer Evelien Dekker | 2022 | World Journal of Gastrointestinal Oncology2022，14，11： | 0 |
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