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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Quantitative Karyotype analysis in the mussel Mytilus edulis显示文摘 | | 1983 | Aquaculture1983，33，： | 1 |
| 3 | Deformable image registration and replanning in head and neck radiotherapy for optimization of parotid sparing 显示文摘 | Meeks S L Manon R R Kupelian P A | 2006 | Int J Radiat Oncol Biol Phys2006，66，： | 1 |
| 4 | Experi-mental investigation of runoff reduction and sediment removal by vege-tated filter strips显示文摘 | Majed Abu-Zreig Ramesh P Rudra Manon N Lalonde | 2004 | Hydrol Process2004，18，： | 1 |
| 5 | Dihydrophenazine derivatives for overcharge protection of rechargeable lithium batteries显示文摘 | FRANCOIS T V MANON P YVES C | 1999 | Electrochimica Acta1999，44，： | 1 |
| 6 | Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis显示文摘 | Katarzyna B Jack P A Manon B | 2005 | Arch Neurol2005，62，： | 1 |
| 7 | Optimal control of hybrid dynamical systems:application in process engineering显示文摘 | Manon P Valentin-Roubinet C Gilles G | 1998 | Control Engineering Practice1998，10，2： | 1 |
| 8 | Cloning, expression, and sequence con- servation of pathogenesis-related gene transcripts of potato 显示文摘 | Manon D P Brisson N | 1989 | Molecular plant-microbe interactions1989，6，2： | 1 |
| 9 | Antiangiogenic activity of paclitexal is associated with its cytostatic effect,mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway显示文摘 | Eddy P Manon C Bertrand P | | 0，，10： | 1 |
| 10 | Fine-needle aspiration cytology of castleman disease:Case report with review of the literature显示文摘 | Majorie D Rene'P Roger T Manon A | 2008 | Diagnostic Cytopathology2008，36，： | 1 |
| 11 | Antiangiogenic activity of paclitexal is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway显示文摘 | Edd P Manon C Bertrand P | 2004 | Mol Cancer Ther October2004，3，10： | 1 |
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