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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Deformable image registration and replanning in head and neck radiotherapy for optimization of parotid sparing 显示文摘 | Meeks S L Manon R R Kupelian P A | 2006 | Int J Radiat Oncol Biol Phys2006，66，： | 1 |
| 3 | A case of Gorhams disease with chylothorax treated curatively with radiation therapy显示文摘 | Duffy BM Manon R Patel RR | 2005 | Clin Med Res2005，3，2： | 1 |
| 4 | Urban soundseapes : Experiences and Knowledge 显示文摘 | MANON R DANIELE D | 2005 | Cities2005，22，5： | 1 |
| 5 | Urban soundscapes: Experiences and knowledge显示文摘 | Manon R Daniele D | 2005 | Cities2005，22，5： | 1 |
| 6 | Potential for radiation therapy technology innovations to permit dose escalation for mon- small cell lung cancer显示文摘 | Manon RR Jardat H Patel R | 2005 | Clin lung cancer2005，7，2： | 1 |
| 7 | Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，34： | 1 |
| 8 | Bioavailability of metformin in tablet form using a new high pressure liquid chromatography assay method显示文摘 | Gilles C Yves L Manon R | 1993 | Biopharmaceu Drug Dispo1993，114，： | 1 |
| 9 | Sensitivity and specificity of muhimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers : results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) 显示文摘 | Manon U Gentry-Maharaj A Hallett R | 2009 | Lancet Oncol2009，10，4： | 1 |
| 10 | Phase Ⅱ trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oneology Group Study (E 6397) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，34： | 1 |
| 11 | Phase Ⅱ trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: An Eastern Cooperative Ontology Group study ( E6397 ) 显示文摘 | Manon R O'Neill A Knisely J | 2005 | J Clin Oncol2005，23，： | 1 |
| 12 | Phase Ⅱ trial of radiosurgea-y for one to three newly diagnosed brain metastases from renal cell eaiei-noma, melanoma, and sarcoma: an Eastern Cooperative 0ncology Group study(E 6397) 显示文摘 | Manon R O' Neill A Knlsely J | 2005 | J din 0neol2005，23，34： | 1 |
| 13 | Phase II trial of radiosurgery for one to three newly diagnosed brain metastatases from renal cell carcinoma, melanoma, and sarcoma : an Eastern Coperative Onco- ogy Group study ( E 6397 ) 显示文摘 | Manon R Oneill A Knisely J | 2005 | Clin Oneol2005，23，34： | 1 |
| 14 | Assessment of a sewage sludge treatment on eadmium, eopper and zine bioavailability in barley, ryegrass and earthworms 显示文摘 | Agnes Y R Sylvie R Manon S | 2007 | EnvironmentalPollution2007，145，： | 1 |
| 15 | Coverage rates for diphtheria,tetanus,poliomyelitis,and pertussis age-specific booster recommendations in France:2018 update of the real-world cohort analysis显示文摘The French National Immunization Program was updated in 2013 for vaccination against diphtheria,tetanus,per-tussis,and poliomyelitis.Our previous findings on the evolution of age-specific booster vaccination coverage rates(VCRs)up to 2017 suggested suboptimal vaccination coverages due to the pre-2013 recommendation-residual vaccination practices.In the current analysis,we evaluated all age-specific booster VCR and distribution of age at vaccination visits in 2018.In this retrospective observational cohort study,the cumulative booster VCRs were updated at all vaccination visits up to 2018 among the people who were eligible for a booster vaccination,using a 1/97th random sample of French national healthcare reimbursement databases.The cumulative booster VCR for individuals from all age groups increased from 2017 to 2018,except for 85-years-old vaccination visit.Majority of the individuals from all age groups were vaccinated(boosted)with a vaccine containing the pertussis valence.In 2018,sharp peaks corresponding to the recommended ages for booster vaccination visits were observed for individuals aged 6,11 to 13,25,45,and 65 years.Our study reiterates suboptimal coverages in France and implies the need for booster vaccination throughout life for the protection of the population. | Régis Verdier Clarisse Marchal Manon Belhassen Marie Le Pannerer Nicole Guiso Robert Cohen | 2023 | Infectious Medicine2023，2，1： | 0 |
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