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| 1 | Preoperative biliary drainage in patients with hilar cholangiocarcinoma undergoing major hepatectomy显示文摘AIM:To investigate the effect of preoperative biliary drainage(PBD)in jaundiced patients with hilar cholangiocarcinoma(HCCA)undergoing major liver resections.METHODS:An observational study was carried out by reviewing a prospectively maintained database of HCCA patients who underwent major liver resection for curative therapy from January 2002 to December 2012.Patients were divided into two groups based on whether PBD was performed:a drained group and an undrained group.Patient baseline characteristics,preoperative factors,perioperative and short-term postoperative outcomes were compared between the two groups.Risk factors for postoperative complications were also analyzed by logistic regression test with calculating OR and 95%CI.RESULTS:In total,78 jaundiced patients with HCCA underwent major liver resection:32 had PBD prior to operation while 46 did not have PBD.The two groups were comparable with respect to age,sex,body mass index and co-morbidities.Furthermore,there was no significant difference in the total bilirubin(TBIL)levels between the drained group and the undrained group at admission(294.2±135.7 vs 254.0±63.5,P=0.126).PBD significantly improved liver function,reducing not only the bilirubin levels but also other liver enzymes.The preoperative TBIL level was significantly lower in the drained group as compared to the undrained group(108.1±60.6 vs 265.7±69.1,P=0.000).The rate of overall postoperative complications(53.1%vs 58.7%,P=0.626),reoperation rate(6.3%vs 6.5%,P=1.000),postoperative hospital stay(16.5 vs 15.0,P=0.221)and mortality(9.4%vs 4.3%,P=0.673)were similar between the two groups.In addition,there was no significant difference in infectious complications(40.6%vs 23.9%,P=0.116)and noninfectious complications(31.3%vs 47.8%,P=0.143)between the two groups.Univariate and multivariate analyses revealed that preoperative TBIL>170μmol/L(OR=13.690,95%CI:1.275-147.028,P=0.031),Bismuth-Corlette classification(OR=0.013,95%CI:0.001-0.166,P=0.001)and extended liver resection(OR=14.010,95%CI:1.130-173.646,P=0.040)were independent risk factors for postoperative complications.CONCLUSION:Overall postoperative morbidity and mortality rates after major liver resection are not improved by PBD in HCCA patients with jaundice.Preoperative TBIL>170μmol/L,Bismuth-Corlette classification and extended liver resection are independent risk factors linked to postoperative complications. | Jun-Jie Xiong Quentin M Nunes Wei Huang Samir Pathak Ai-Lin Wei Chun-Lu Tan Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，46： | 33 |
| 2 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 3 | Intravenous β-artemether formulation (ARM NLC) as a superior alternative to commercial artesunate formulation显示文摘 | Patil S Joshi M Pathak S | 2012 | J Antimicrob Che- mother2012，67，11： | 1 |
| 4 | Granulocytie sarcoma presenting as tumors of the cervix 显示文摘 | Pathak B Bruchim I Brisson M L | 2005 | Gynecol Oncol2005，98，3： | 1 |
| 5 | Execution of macro- phage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by toll-like receptor 2-dependent release of tumor necrosis factor-alpha显示文摘 | Basu S Pathak SK Banerjee A Pathak S Bhattaeharyya A Yang Z Talarieo S Kundu M Basu J | 2007 | J Biol Chem2007，282，2： | 1 |
| 6 | Bioleaching of heavy metals from sewage sludge by indigenous iron- oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources :a comparative study 显示文摘 | Pathak A Dastidar M G Sreekrishnan T R | 2009 | J HazardMat2009，171，： | 1 |
| 7 | The co - operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits in- creased humoral and cell mediated immune response显示文摘 | Tundup S Pathak N Rarnanadham M | 2008 | PL One2008，3，10： | 1 |
| 8 | Bioleaching of heavy metals from sewage sludge: a review 显示文摘 | Ashish Pathak Dastidar M G Sreekrishnan T R | 2009 | Environmental Management2009，90，8： | 1 |
| 9 | Expert consensus: renal denervation for the treatment of hypertension 显示文摘 | Pathak A Girerd X Azizi M | 2012 | Diagn Interv Imaging2012，93，5： | 1 |
| 10 | Necrotizing pneumonia caused by group C streptococci in a young adult显示文摘 | Pathak V Hurtado Rendon IS Smina M | | 0，，03： | 1 |
| 11 | Granulocytic sarcoma presenting as tumors of the cervix显示文摘 | Pathak B Bruchim I Brisson M L | | 0，，： | 1 |
| 12 | DNA methylation induced changes in chromatin confor- mation of the promoter of the vitellogenin II gene of Japanese quail during aging 显示文摘 | GUPTA S PATHAK R U KANUNGO M S | 2006 | Gene2006，377，： | 1 |
| 13 | Alphavbeta3-integrin antagonists inhibit thrombin-induced proliferation and focal adhesion formation in smooth muscle cells显示文摘 | Sajid M Zhao R Pathak A | 2003 | Am J Physiol Cell Physiol2003，285，5： | 1 |
| 14 | Ursolic acid in- hibits STAT3 activation pathway leading to suppression of pro- liferation and chemosensitization of human multiple myeloma cells显示文摘 | PATHAK AK BHUTANI M NAIR AS | 2007 | Mol Cancer Res2007，5，9： | 1 |
| 15 | Catalytic conversion of glycerol to value added liquid products显示文摘 | PATHAK K REDDY K M DALAI A K | 2010 | Applied Catalysis A:General2010，372，2： | 1 |
| 16 | Multi-year investigations of near surface and columnar aerosols over Dibrugarh, northeastern location of India: Heterogeneity in source impacts显示文摘 | Mukunda M Gogoi Binita Pathak Binita Pathak | 2011 | Atmospheric Envi- ronment2011，45，： | 1 |
| 17 | Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters显示文摘 | Saxena M Stephens MA Pathak H | | 0，，02： | 1 |
| 18 | Adverse health effects of pesticides in agrarian populations of developing countries显示文摘 | Kesavachandran C N Fareed M Pathak M K | 2009 | Rev Environ Contam Toxicol2009，200，： | 1 |
| 19 | A comparative study of flow boiling heat transfer in three different configurations of microehannels 显示文摘 | Prajapati Y K Pathak M Kaleem K M | 2015 | International Journal of Heat and Mass Transfer2015，85，： | 1 |
| 20 | Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype显示文摘 | Pathak AP Artemov D Neeman M | 2006 | Cancer Res2006，66，10： | 1 |
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