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| 1 | Brain up take of nonsteroidal antiinflammatory drugs: ibuprofen, flurbiprofen, and indomethacin 显示文摘 | Parepally J M Mandula H Smith QR | 2006 | Pharm Res2006，23，6： | 1 |
| 2 | Brain uptake of nonsteroidal anti-inflammatory drugs:ibuprofen,flurbiprofen,and indomethacin显示文摘 | Parepally JM Mandula H Smith QR | 2006 | Pharm Res2006，23，5： | 1 |
| 3 | Brain uptake of nonsteroidal anti-inflammatory drugs:ibuprofen,flurbiprofen,and indomethacin显示文摘 | Parepally JM Mandula H Smith QR | | 0，，05： | 1 |
| 4 | Brain uptake of nonsteroidal antiinflammatory drugs:ibuprofen,flurbiprofen,and indomethacin显示文摘 | Parepally JM Mandula H Smith QR | 2006 | Pharm Res2006，23，6： | 1 |
| 5 | Brain uptake of nonsteroidal anti-inflammatory drugs:ibuprofen,flurbiprofen,and indomethacin显示文摘 | Parepally JM Mandula H Smith QR | | 0，，06： | 1 |
| 6 | 腔内三角吻合在腹腔镜右半结肠癌切除术中的应用:一项安全有效的消化道重建技术显示文摘背景:腔内三角吻合(IDA)是腹腔镜消化道重建技术的一个重要进展。我们将该技术应用于腹腔镜右半结肠癌切除术,并对其与传统腔外吻合技术(EA)的短期疗效进行比较。方法:2016年1月1日至2017年10月1日间,分别有36例和50例腹腔镜右半结肠癌手术患者采用了IDA和EA进行消化道重建。收集并比较两组患者临床病理特征、手术资料、术后恢复情况及术后并发症。结果:除了IDA组患者手术切口长度相对较短外[(4.660.6)vs(5.660.7)cm,P<0.001],两组患者临床病理特征及手术指标相似。术后下地活动时间、进流食时间和术后住院时间两组患者的差异均无统计学意义,但术后排气时间IDA组明显快于EA组[(2.860.5)vs(3.260.8)days,P=0.004]。术后第1和第3天视觉模拟疼痛评分IDA组均低于EA组(分别为:4.060.7 vs 4.561.0,P=0.002和2.760.6 vs 3.460.6,P<0.001)。IDA组和EA组患者术后并发症发生率分别为8.3%和16.0%(P=0.470)。无一例患者出现吻合口出血、狭窄或漏等吻合口并发症。结论:腔内三角吻合是一项安全可行的消化道重建方式,其短期疗效较传统腔外吻合更为满意。 | Hao Su Wei-Sen Jin Peng Wang Mandula Bao Xue-Wei Wang Qian Liu Xi-Shan Wang Zhi-Xiang Zhou Hai-Tao Zhou | 2019 | Gastroenterology Report2019，7，4： | 1 |
| 7 | Brain Uptake of Nonsteroidal Anti-Inflammatory Drugs: Ibuprofen, Flurbiprofen, and Indomethacin显示文摘 | Jagan Mohan R. Parepally Haritha Mandula Quentin R. Smith | 2006 | Pharmaceutical Research2006，，5： | 1 |
| 8 | Phys Rev显示文摘 | COLEMAN S MANDULA J | 1967 | (159): 1 2511967，，159： | 1 |
| 9 | Brain uptake of nonsteroidal anti-inflammatory drugs:ibuprofen,flurbiprofen,and indomethacin显示文摘 | Parepally JM Mandula H Smith QR | | 0，，05： | 1 |
| 10 | Brain uptake of non- steroidal anti-inflammatory drugs: boprofen, flurbiprofen, and indomethaein显示文摘 | Parepally J M Mandula H Smith Q R | 2006 | Pharm Res2006，23，5： | 1 |
| 11 | Brain uptake of nonsteroidal anti-inflammatory drugs : ibuprofen, flurbiprofen, and indomethacin 显示文摘 | Parepally JM Mandula H Smith QR | 2006 | Pharm Res2006，23，5： | 1 |
| 12 | Prediction of noise from trams显示文摘 | Jan Mandula Brigita Salaiova | 2002 | Applied Acoustics2002，63，4： | 1 |
| 13 | Homogeneous line- width measurements of Yb3+ ions in congruent and stoichio- metric lithium niobate crystals显示文摘 | KIS Z Mandula G LENGYEL K | 2014 | Optical Materials2014，37，： | 1 |
| 14 | Prediction of noise from trams显示文摘 | Mandula J Salaiova B Koval'akova M | 2002 | Applied Acoustics2002，63，： | 1 |
| 15 | Brain uptake of nonste-roidal antiinflammatory drugs : ibuprofen, flurbiprofen, and indomethacin 显示文摘 | Parepally JM Mandula H Smith QR | 2006 | Pharm Res2006，23，5： | 1 |
| 16 | The constitution of the Cu-9Ni-6Sn alloy determined by changes of the strength and by structure determination during annealing显示文摘 | Kratochvil P Mandula M Mencl J | 1987 | Physica Status Solidi (A)1987，104，2： | 1 |
| 17 | Brain uptake of nonsteroidal anti- inflammatory drugs : ibuprofen, flurbipro- fen ,and indomethacin显示文摘 | PAREPALLY J M MANDULA H SMITH Q R | 2006 | Pharm Res2006，23，： | 1 |
| 18 | The high quality technical research of road concrete recycled coarse aggregate显示文摘 | Mandula M Hu X Y Chen F J Zhang W L | 2011 | Advanced Materials Research2011，346，： | 1 |
| 19 | Brain uptake of nonste - roidal antiinflammatory drugs: ibuprofen, flurbiprofen, and indomethacin显示文摘 | Parepally J M Mandula H Smith Q R | 2006 | Pharm Res2006，23，： | 1 |
| 20 | The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model显示文摘Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine model.Methods:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 software.For the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine model.Pre-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior tests.RNA sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal nerve.Results:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass spectrometry.We discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology database.The“compound-target-disease”network contained 163 intersection targets with the migraine state.Gene Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,etc.When Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,etc.These predictions were further demonstrated via in vivo animal model experiments.The RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreated group.Those genes were mainly involved in neuromodulation,vascular function,and hormone metabolism.Conclusion:The 55 bio-active components in Horcha-6 regulate inflammation,hormone metabolism,and neurotransmitters and have potential as a therapy to treat migraines. | Ao Qier Naren Mandula Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang | 2024 | Traditional Medicine Research2024，9，2： | 0 |
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