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| 1 | Brain metastases as preventive and therapeutic targets显示文摘 | Steeg PS Camphausen KA Smith QR | 2011 | 中国神经肿瘤杂志2011，9，1： | 16 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Study on New Spectrophotometric Determination of Vanadium(V) with Chlorpromazine显示文摘By using chlorpromazine as a new color reagent, spetrophotometric reactions with vanadium(V) have been studied. In the medium of 0.25 mol·L-1 of H2SO4 chlorpromazin reacts with vanadium(V) at room temperature to form a bright red complex, which exhibits a maximum absorption at 520 nm. Beer’s law is obeyed in the concentration range of 0-2μg and 2-40μg V(V)/10mL with molar absorptivities of 5. 10×103 and 1.02×104L·mol-1·cm-1, | Wang, YB Li, QR | 1997 | Chinese Chemical Letters1997，8，4： | 2 |
| 4 | Neuronal regulation of the spatial patterning of neurogenesis 显示文摘 | Gonzalez QR Lee Y Poss KD | 2010 | Dev Cell2010，18，1： | 1 |
| 5 | Sonic hedgehog regulated oligodendrocyte lineage genes encoding bHLH proteins in tile mammalian central nervous system 显示文摘 | Lu QR Yuk D Alberta JA | 2000 | Neuron2000，25，2： | 1 |
| 6 | Partial purification of hu- man parathyroid hormone 1-84 as a thioredoxin fusion form in recombinant Eacherichia coli by thermoosmotic shock 显示文摘 | Guo QR Wei DZ Tong WY | 2006 | Protein Expr Purif2006，49，1： | 1 |
| 7 | Molecular Characterizationof Drug-Resistant Mycobacterium tuberculosis Isolates fromSichuan Province in China 显示文摘 | Guo JH Xiang WL Zhao QR | 2008 | Jpn J Infect Dis2008，61，4： | 1 |
| 8 | Different effects of farrerol on an OVA-induced al- lergic asthma and LPS-induced acute lung injury 显示文摘 | Ci XX Chu X Wei MM Yang XF Cai QR Deng XM | 2012 | Plos One2012，7，： | 1 |
| 9 | Specific in vitro association between the hepatitis C viral genome and core protein显示文摘 | Fan Z Yang QR Twu JS | 1999 | J Med Virol1999，59，2： | 1 |
| 10 | Changes of plasma D(-)-lactate,diamine oxidase and endotoxin in patients with liver cirrhosis显示文摘 | Ruan P Gong ZJ Zhang QR | | 0，，01： | 1 |
| 11 | Positive lymph node ratio is an in- dependent prognostic factor in gastric cancer after d2 resection regard- less of the examined number of lymph nodes 显示文摘 | Xu DZ Geng QR Long ZJ | 2009 | Ann Surg Oncol2009，16，9： | 1 |
| 12 | Participation in cardiac rehabilitation and surviwal after coronary artery bypass graft surgery: a community-based study显示文摘 | Pack QR Goel K Lahr BD | 2013 | Circulation2013，128，6： | 1 |
| 13 | Influence of protein self-association on complex coacervation with polysaccharide: a monte carlo study显示文摘 | Li YQ Huang QR | 2013 | Journal of Physical Chemistry B2013，117，： | 1 |
| 14 | Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection显示文摘 | Lu QR Sun T Zhu Z | 2002 | Cell2002，109，： | 1 |
| 15 | Clinical staging and managing strategy of hand foot and mouth disease 显示文摘 | Zhu QR Huang LM Yang SD | 2009 | Chin J Evid Based Pedaitr2009，4，3： | 1 |
| 16 | Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice显示文摘 | Chen QR Kumar D Stass SA | 1999 | Cancer Res1999，59，14： | 1 |
| 17 | Saturable transport of manganese (Ⅱ) across the rat blood brain barrier显示文摘 | Murphy VA Wadhwani KC Smith QR | 1991 | J Neurochem1991，57，3： | 1 |
| 18 | Establishment of murine bone marrow derived endothelial cells显示文摘 | Wang QR Yan Y Wang BH | 1997 | J Exp Hematol1997，5，： | 1 |
| 19 | Seroprevalence of Bordetella pertussis antibody in children and adolescents in China显示文摘 | Wang CQ Zhu QR | 2011 | Pediatr Infect Dis J2011，30，7： | 1 |
| 20 | Context - induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos- expressing dorsolateral striatum neurons显示文摘 | Rubio FJ Liu QR Li X | 2015 | 35 (14): 5625 -56392015，35，14： | 1 |
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