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| 1 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 2 | Cardiac matrix metalloproteinase -2 expression independently induces marked ventricular remodeling and systolic dysfunction显示文摘 | Bergman MR Teerlink JR Mahimkar R | 2007 | Am J Physiol Heart Circ Physiol2007，292，4： | 1 |
| 3 | Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury 显示文摘 | Cheng S Pollock A S Mahimkar R | 2006 | FASEB J2006，20，11： | 1 |
| 4 | Cardiac matrix metalloproteinase - 2 expression independently induces marked ventricular remodeling and systolic dysfunction 显示文摘 | Berqman MR Teerlink JR Mahimkar R | 2007 | Am J Physiol Heart Circ Physiol2007，292，4： | 1 |
| 5 | Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction显示文摘 | Bergman MR Teerlink JR Mahimkar R | | 0，，： | 1 |
| 6 | Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction显示文摘 | Bergman M R Teerlink J R Mahimkar R | 2006 | Am J Physiol Heart Circ Physiol2006，292，4： | 1 |
| 7 | Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy显示文摘 | Manoj B. Mahimkar Tanuja A. Samant Sadhana Kannan Jatin Tulsulkar Prathamesh S. Pai Devasena Anantharaman | 2011 | Mol. Carcinog2011，，1： | 1 |
| 8 | Matrixmetalloproteinase 2 and basement membrane integrity : aunifying mechanism for progressive renal injury 显示文摘 | Cheng S Pollock AS Mahimkar R | 2006 | FASEB J2006，20，11： | 1 |
| 9 | Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB显示文摘 | Alfonso-Jaume MA Bergman MR Mahimkar R | 2006 | Am J Physiol Heart Circ Physiol2006，291，： | 1 |
| 10 | Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury显示文摘 | Cheng S Pollock AS Mahimkar R | 2006 | FASEB J2006，20，11： | 1 |
| 11 | Cardiac matrix met- alloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction 显示文摘 | Bergman MR Teerlink JR Mahimkar R | 2007 | Am J Physiol Heart Circ Physiol2007，2，92： | 1 |
| 12 | TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation显示文摘 | Doedens J R Mahimkar R M Black R A | 2003 | Biochem Biophys Res Commun2003，308，2： | 1 |
| 13 | Cardiac matrix metalloproteinase - 2 expression independently induces marked ventricular re- modeling and systolic dysfunction 显示文摘 | Bergman MR Teerlink JR Mahimkar R | 2007 | Am J Physiol Heart Circ Phys- iol2007，292，4： | 1 |
| 14 | , A proteomic approach for the identification of cell-surface proteins shed by metalloproteases 显示文摘 | EISENMAN J R MAHIMKAR R M | 2002 | Mol Cell Proteo2002，1，1： | 1 |
| 15 | Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB 显示文摘 | Alfonso-Jaume MA Bergman MR Mahimkar R | 2006 | Am J Physiol Heart Circ Physiol2006，291，4： | 1 |
| 16 | Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction 显示文摘 | BERGMAN MR TEERLINK JR MAHIMKAR R | 2007 | Am J Physiol Heart Circ Physiol2007，292，4： | 1 |
| 17 | A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity显示文摘 | Lovett DH Mahimkar R Raffai RL | 2012 | PLo S One2012，7，34： | 1 |
| 18 | Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype显示文摘 | Mahimkar R Alfonso-Janme MA Cape LM | 2011 | Carcinogenesis2011，32，12： | 1 |
| 19 | Cardiac ischemia - reperfusion injury induces matrix metalloproteinase - 2 expression through the AP - 1 components FosB and JunB显示文摘 | ALFONSO JAUME M A BERGMAN M R MAHIMKAR R | 2006 | Am J Physiol Heart Circ Physiol2006，291，4： | 1 |
| 20 | Matrix metalloproteinase 2 and basement membrane integrity:a unifying mechanism for progressive renal injury显示文摘 | Cheng S Pollock AS Mahimkar R | 2006 | FASEB J2006，20，11： | 1 |
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