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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Potential isotopic and chemical markers for charactcrising organic fruits 显示文摘 | Camin F Perini M Bontcmpo L Fabroni S Faedl W Magnani S Baruzzi G Bonoli M Tabilio M R Musmeei S | 2011 | Food Chemistry2011，125，： | 1 |
| 3 | Biochemical charac- terization of two GALK1 mutations in patients with galactokinase deficiency 显示文摘 | Sangiuolo F Magnani M Stambolian D | 2004 | Hum Mutat2004，23，4： | 1 |
| 4 | Three step monoclonal antitumor targeting in carcinoembryonic antigen-positive patients显示文摘 | Paganelli G Magnani P Zito F | 1991 | Cancer1991，51，： | 1 |
| 5 | Infrared thermography applied to the quantitative determination of spatial and thermophysical parameters of hidden included objects 显示文摘 | F S Magnani R N T-da Silva | 2007 | Applied Thermal Engineering2007，27，： | 1 |
| 6 | The human footprint in the carbon cycle of tem-perate and boreal forests显示文摘 | Magnani F | 2007 | Nature2007，447，7146： | 1 |
| 7 | The Human Footprint in the Carbon Cycle of Temperate and Boreal Forests 显示文摘 | MAGNANI F MENCUCCINI M BORGHETTI M | 2007 | Nature2007，447，7146： | 1 |
| 8 | Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation显示文摘 | Marktel S Magnani Z Ciceri F | 2003 | Blood2003，101，4： | 1 |
| 9 | Regulation of the serotonin transporter by interacting proteins显示文摘 | Haasel J Killian A Magnani F | 2001 | Biochem Soc Trans2001，29，： | 1 |
| 10 | The response of Pinus syl-vestris to drought : stomatal control of transpiration and hydraulicconductance显示文摘 | Irvine J Perks M P Magnani F | 1998 | Tree Physiology1998，18，6： | 1 |
| 11 | Stomatal, mesophyll conductance and biochemical limitations to photosynthesis as affected by drought and leaf ontogeny in ash and oak trees显示文摘 | Grassi G Magnani F | 2005 | Plant Cell and Environment2005，28，7： | 1 |
| 12 | The human footprint in the carbon cycle of temperate and boreal forests显示文摘 | Magnani F Mencuccini M Borghetti M | 2007 | 447(7146): 849-8512007，447，7146： | 1 |
| 13 | Investigation of the corrosion behavior of AA 2024-T3 in low concentrated chloride media 显示文摘 | QUEIROZ F M MAGNANI M COATA I de MELO H G | 2008 | Corrosion Science2008，50，9： | 1 |
| 14 | Stomatal,mesophyll conductance and biochemical limitations to photosynthesis as affected by drought and leaf ontogeny in ash and oak trees显示文摘 | Grassi G Magnani F | | 0，，07： | 1 |
| 15 | Erythrocytes as a novel delivery vehicle for biologics:from enzymes to nucleic acid-based therapeutics 显示文摘 | MAGNANI M PIERIGE F ROSSI L | 2012 | Ther Deliv2012，3，3： | 1 |
| 16 | PLZF expression during colorectal cancer development and in normal colorectal mucosa according to body size, as marker of colorectal cancer risk 显示文摘 | Mariani F Sena P Magnani G | 2013 | Scientific World Journal2013，2013，63： | 1 |
| 17 | External servicing testbed for automation and robotics 显示文摘 | Colombina G Didot F Magnani G | 1996 | IEEE Robotics and Automation Magazine1996，3，1： | 1 |
| 18 | Age-related decline in stand productivity: The role of structural acclimation under hydraulic constraints显示文摘 | Magnani F Mencuccini M Grace J | 2000 | Plant Cell and Environment2000，23，： | 1 |
| 19 | DEMO relevance of the test blanket modules in ITER-application to the European test blanket modules显示文摘 | Magnani E Gabriel F Boccaccini L V | 2010 | Fusion Engineering and Design2010，85，79： | 1 |
| 20 | The human footprint in the carbon cycle of temperate and boreal forests显示文摘 | Magnani F Mencuceini M Borghetti M | 2007 | Nature2007，447，： | 1 |
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