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| 1 | Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions显示文摘AIM: To assess the diagnostic accuracy of endoscopic ultrasound (EUS), fluid tumor markers and cytology in distinguishing benign from (pre)malignant pancreatic cystic lesions. METHODS: 46 consecutive patients, referred to a gastroenterologist and surgeon for a symptomatic or incidental pancreatic cyst, were reviewed. EUS, cytology, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) levels were compared with the final diagnosis, based on surgical pathology and/or imaging follow-up of at least 12 mo. Cysts were classified as benign (pseudocyst, serous cystadenoma) or malignant/ pre-malignant (mucinous cystic neoplasm). Receiver- operator characteristics (ROC) curve analysis was performed. RESULTS: The mean age was 56 years; 29% were male and median cyst diameter was 3 cm. Final outcome was obtained in 41 (89%) patients. Twenty-three (56%) of these 41 had surgical pathology. Twenty-three (56%) had benign lesions and 18 (44%) had malignant/pre- malignant lesions. Sensitivity, specificity and positive and negative predictive value of EUS alone to distinguish benign from malignant/premalignant pancreatic cystic lesions were 50%, 56%, 36% and 54% and for cytology were 71%, 96%, 92% and 85%, respectively. The corresponding values for the ROC-derived ideal cutoffswere 75%, 90%, 75%, 90% for CA 19-9 (> 37 U/mL) and 70%, 85%, 79% and 78% for CEA (> 3.1 ng/mL). Subgroup analysis of those with surgical pathology yielded almost identical performance and cutoffs. CONCLUSION: Cytology and cyst fluid tumor marker analysis is a very useful tool in distinguishing benign from (pre)malignant pancreatic cystic lesions. | Abdulrahman M Aljebreen Joseph Romagnuolo Rafael Perini Francis Sutherland | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 2 | Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients显示文摘 | Perini F Morra M Alecci M | 2001 | Neurol Sci2001，22，4： | 1 |
| 3 | Expressing the human genome显示文摘 | PERINI G GREEN M R | 2001 | Nature2001，409，： | 1 |
| 4 | Temporal profile of serumm antiinflammatory and pro-inflammatory interleukins in acute ischemic stroke patients显示文摘 | Perini F Morra M Alecci M | 2001 | Neurol Sci2001，22，： | 1 |
| 5 | Potential isotopic and chemical markers for charactcrising organic fruits 显示文摘 | Camin F Perini M Bontcmpo L Fabroni S Faedl W Magnani S Baruzzi G Bonoli M Tabilio M R Musmeei S | 2011 | Food Chemistry2011，125，： | 1 |
| 6 | Outcomes of chol- ecystectomy for treatment of acute cholecystitis in octogenarians 显示文摘 | Nikfarjam M Yeo D Perini M | 2013 | ANZ J Surg2013，，： | 1 |
| 7 | Control of wine vinegar authenticity through δ18O analysis显示文摘 | CAMIN F BONTEMPO L PERINI M | 2013 | Food Control2013，29，1： | 1 |
| 8 | Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients显示文摘 | Perini F Morra M Alecci M | 2001 | Neurol Sci2001，22，4： | 1 |
| 9 | Characterisation of authentic Italian extra-virgin olive oils by stable isotope ratios of C, O and H and mineral composition显示文摘 | Camin F Larcher R Perini M | 2010 | Food Chemistry2010，118，4： | 1 |
| 10 | Systolic blood pressure contribures to intracerebral hemorrhage after thrombolysis fir ischemic stroke显示文摘 | Perini F De Boni A Marcon M et L | 2010 | J Neurol Sci2010，297，112： | 1 |
| 11 | Temporal profile ofserum anti-inflammatory and pro-inflammatory interleukinsin acute ischemic stroke patients显示文摘 | Perini F Morra M Alecci M | 2001 | Neurol Sci2001，22，： | 1 |
| 12 | Characterisation of authentic Italian extra-virginolive oils by stable isotope ratios of C, O and Hand mineral composition 显示文摘 | CAMIN F LARCHER R PERINI M | 2010 | Food Chemistry2010，118，4： | 1 |
| 13 | PAS-1 ,a protein from Ascaris suum, modulates allergic inflammation via IL-10 and IFN-gamma, but not IL-12 显示文摘 | ARAuJO C A PERINI A MARTINS M A | 2008 | Cytokine2008，44，3： | 1 |
| 14 | Multielement (H, C, N, O, S) stable isotope characteristics of lamb meat from different Italian regions 显示文摘 | Perini M Camin F Bontempo L | 2009 | Rapid Communi- cations in Mass Spectrometry2009，23，： | 1 |
| 15 | Human airway mucin glycosylation:a combinatory of carbohydrate determinants which vary in cystic fibrosis显示文摘 | Lamblin G Degroote S Perini J M | 2001 | Glycoconj2001，18，： | 1 |
| 16 | Metabolic and cardiorespriatory responses to maximal intermittent knee isokinetic exercise in young healthy humans显示文摘 | Perini R Milesi S | 2000 | Eur J Appl Physio2000，81，4： | 1 |
| 17 | Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients : a single centreprospective study 显示文摘 | Atzori M Battistella PA Perini P | 2009 | Mult Scler2009，15，3： | 1 |
| 18 | The HLA-DR13 haplotype is associated with 'benign' multiple sclerosis in Northeast Italy显示文摘 | Perini P Tagliaferri C Belloni M | 2001 | Neurology2001，57，1： | 1 |
| 19 | No evidence of chronic cerebrospinal venous insufficiency in clinically isolated syndrome suggestive of MS显示文摘 | Baracchini C Perini P Calabrese M | 2011 | Ann Neurol2011，69，1： | 1 |
| 20 | Isotopic and elemental data for tracing the origin of European olive oils显示文摘 | Camin F Larcher R Nicolini G Bontempo L Bertoldi D Perini M Schlicht C Schellenberg A Thomas F Heinrich K Voerkelius S Horacek M Ueckermann H Froeschl H Wimmer B Heiss G Baxter M Rossmann A HoogewerffJ | 2010 | Journal of Agricultural and Food Chemistry2010，58，1： | 1 |
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