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| 1 | Therapeutic options for the management of pancreatic cancer显示文摘Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause of death in the United States, resulting in an estimated 38460 deaths annually. With few screening tools available to detect this disease at an early stage, 94% of patients will die within five years of diagnosis. Despite decades of research that have led to a better understanding of the molecular and cellular signaling pathways in pancreatic cancer cells, few effective therapies have been developed to target these pathways. Other treatment options have included more sophisticated pancreatic cancer surgeries and combination therapies. While outcomes have improved modestly for these patients, more effective treatmentsare desperately needed. One of the greatest challenges in the future of treating this malignancy will be to develop therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cells in addition to pancreatic cancer cells. Recent advances in targeting pancreatic stellate cells and the stroma have encouraged researchers to shift their focus to the role of desmoplasia in pancreatic cancer pathobiology in the hopes of developing newer-generation therapies. By combining novel agents with current cytotoxic chemotherapies and radiation therapy and personalizing them to each patient based on specific biomarkers, the goal of prolonging a patient's life could be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential of therapeutic options. | Maria L Rossi Azeem A Rehman Christopher S Gondi | 2014 | World Journal of Gastroenterology2014，20，32： | 13 |
| 2 | Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells显示文摘AIM:To investigate effects of iron on oxidative stress, heme oxygenase-1(HMOX1)and hepatitis C viral(HCV) expression in human hepatoma cells stably expressing HCV proteins. METHODS:Effects of iron on oxidative stress,HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction,and protein levels by Western blots. RESULTS:Iron,in the form of ferric nitrilotriacetate,increased oxidative stress and up-regulated HMOX1 gene expression.Iron did not affect mRNA or protein levels of Bach1,a repressor of HMOX1.Silencing the up-regulation of HMOX1 nuclear factor-erythroid 2-related factor 2(Nrf2)by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOX1 mRNA levels.These iron effects were completely blocked by deferoxamine(DFO).Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90%and protein by about 50%in the Con1 full length HCV replicon cells, whereas DFO increased them. CONCLUSION:Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells.This probably mitigates liver injury caused by combined iron overload and HCV infection. | Wei-Hong Hou Lisa Rossi Ying Shan Jian-Yu Zheng Richard W Lambrecht Herbert L Bonkovsky | 2009 | World Journal of Gastroenterology2009，15，36： | 5 |
| 3 | 氧化锆陶瓷的临床应用显示文摘 | Manicone PF Rossi Iommetti P Raffaelli L 刘小舟 吕培军 | 2008 | 中国实用口腔科杂志2008，1，1： | 3 |
| 4 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 5 | Routing schemes in heterogeneous wireless networks based on access advertisement and backward utilities for QoS support 显示文摘 | BADIA L MIOZZO M ROSSI M | 2007 | IEEE Communications Magazine2007，45，2： | 1 |
| 6 | Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6 beta-glucuronide antinociception显示文摘 | Leventhal L Pan YX | 1997 | J Pharmacol Exp Ther1997，281，1： | 1 |
| 7 | Gene expression, neurogenesis, and healing: psychosocial genomics of therapeutic hypnosis显示文摘 | Rossi E L | 2003 | Am J Clin Hypn2003，45，3： | 1 |
| 8 | Lessons from the ( ' Iressa' expanded access programme: Gefitinib in special non-small-cell lung cancer patient populations 显示文摘 | Stahel R Rossi A Petruzelka L Kosimidis P de Braud F Bernardo MM | 2003 | Br J Cancer2003，89，2： | 1 |
| 9 | Colorimetry of total phenols with phos-phomolybdic phosphotungstic acid reagets显示文摘 | SIGLETON V L ROSSI J A | 1965 | American Journal ofEnology and Viticulture1965，16，： | 1 |
| 10 | Colorimetry of total phenolics with phos-phomolybdic-phosphotungsticacid reagents显示文摘 | SINGLETON V L ROSSI J | 1965 | American Journal of Enol-ogy and Viticulture1965，16，： | 1 |
| 11 | The nematode resistance gene Mi of tomato confers resistance against the potato aphid显示文摘 | Rossi M Goggin F L Milligan S B | 1995 | Proceedings of the National Academy of Sciences USA1995，95，： | 1 |
| 12 | Selective oxidation of D-glucose on gold catalyst显示文摘 | Biella S Prati L Rossi M | 2002 | Journal of catalysis2002，206，2： | 1 |
| 13 | Prospective randomized study on reversed saphenous vein in frapopliteal bypass to treat limb-threatening ischemia: comm on femoral artery versus superficial femoral or pop li-teal and tibial arteries as inflow 显示文摘 | Ballotta E Renon L De Rossi A | 2004 | Vasc Surg2004，40，4： | 1 |
| 14 | Human sperm cryopreservation and reactive oxygen species (ROS) production 显示文摘 | Mazzilli F Rossi T Sabatini L | 1995 | Acta Europaea Fertilitatis1995，26，4： | 1 |
| 15 | Mechanisms of resistance to growth inhibition and killing by beta-laetam antibiotics in enteroeoeei显示文摘 | Fontana R Amalfitano G Rossi L | 1992 | Clin Infect Dis1992，15，3： | 1 |
| 16 | Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial显示文摘 | Pantoni L Rossi R Inzitari D | 2000 | J Neurol Sci2000，175，2： | 1 |
| 17 | Colorimetry of total phenols with phosphomolybdic phosphotungstic acid reagents显示文摘 | Singleton V L Rossi J A | 1965 | American Journal of Enology Viticuture1965，，16： | 1 |
| 18 | Performance analysis of a hybrid incremental and cyclic AID conversion principle显示文摘 | Rossi L Tanner S Farine P A | 2009 | IEEE Transactions on Circuits and Systems I: Regular Papers2009，56，7： | 1 |
| 19 | Colorimetry of total phenolics withphosphomolybdic- phosphotungstic acid reagents 显示文摘 | Singleton V L Rossi J A | 1965 | AmericanJournal of Enoloav and Viticulture1965，，16： | 1 |
| 20 | Simplified flamemodels and prediction of the thermal radiation emitted by a flamefront in an outdoor fire 显示文摘 | ROSSI J L CHETEHOUNA K COLLIN A’ | 2010 | Combustion science & technology2010，182，10： | 1 |
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