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| 1 | 全流量大鼠体外循环模型的建立显示文摘目的建立可存活全流量的大鼠体外循环(cardiopulmonary bypass,CPB)模型。方法8只雄性Sprague-Dawley大鼠异氟烷吸入诱导麻醉后,经口气管内插管,接呼吸机行机械通气。进行尾动脉、腹壁尾侧浅动静脉和右侧颈外静脉血管穿刺置管等外科准备。经颈外静脉置入的多孔套管为静脉引流通道,以经尾动脉置入套管为CPB动脉灌注管道,血液经过特制膜氧合器进行氧合建立CPB并进行90 min CPB灌注。实验动物均进行血气和血流动力学等基本生理指标监测,并在CPB前、CPB后60 min以及CPB后1周测定细胞因子(IL-6和IL-10)以了解CPB所致的大鼠全身炎症情况。结果成功建立了不输血全流量大鼠CPB模型,所有实验动物全部存活至7天以上。受试动物IL-6和IL-10在CPB后显著升高,一周后回降到术前正常水平。结论本实验成功建立了全流量大鼠CPB模型,CPB后大鼠出现明显的全身炎症反应,这为研究CPB并发症病理生理机制以及相应的应对策略提供可靠经济的动物模型。 | 朱斌 Mihai V. Podgoreanu G. Burkhard Mackensen 叶铁虎 黄宇光 | 2009 | 中国体外循环杂志2009，7，3： | 7 |
| 2 | Linkage between Seasonal Insolation Gradient in the Tropical Northern Hemisphere and the Sea Surface Salinity of the Equatorial Indian Ocean during the Last Glacial Period显示文摘Paired stable oxygen isotope and Mg/Ca analyses in calcite tests of the mixed-layer-dwelling planktic foraminifer Globigerinoides ruber has been used to reconstruct equatorial Indian Oceanδ18O of seawater (δ18Osw ) over the last ~137 thousand years. On the basis of ice-volume-corrected δ18Osw (δ18Osw-ivc ), relative changes in sea surface salinity (SSS) have been estimated. The SSS estimates suggest three episodes of higher SSS (131-113 thousand years before present (kyr BP), 62-58 kyr BP, and 30-24 kyr BP) within the last glacial period as compared with the present. SSS comparison between interglacial episodes reveals that the surface seawater over the core site was significantly saltier during the penultimate interglacial than the Holocene. We suggest that the evolution of a seasonal insolation gradient between the Indian monsoon areas and the equator over the investigated time interval was instrumental in shaping the strength of the Indian winter and summer monsoons that left their imprints on the equatorial Indian Ocean SSS via freshwater input and wind-induced mixing. The study shows that the insolation difference between northern latitudes and the equator during winter affects monsoon strength in the Indian region, especially during cold intervals. | Saraswat RAJEEV Nigam RAJIV Mackensen ANDREAS Weldeab SYEE | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 2 |
| 3 | Induction and clonal expansion of tumor - specific cytotoxic T lymphocytes from renal cell carcinoma patients after stimulation with autologous dendritic cells loaded with tumor cells显示文摘 | KUROKAWA T OELKE M MACKENSEN A | 2001 | Int J Cancer2001，91，6： | 1 |
| 4 | Primary fibroblasts from human adults as target cells for exvivo transfection and gene therapy 显示文摘 | Veelken H Jesuiter H Mackensen A | 1994 | Hum Gene Ther1994，14，5： | 1 |
| 5 | Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion显示文摘 | Blank C Mackensen A | 2007 | Cancer Im munol Immunother2007，56，5： | 1 |
| 6 | Neurological injury during cardiopulmonary bypass in the rat显示文摘 | Grocott HP Mackensen GB Newman MF | 2001 | Perfusion2001，16，1： | 1 |
| 7 | Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion显示文摘 | Blank C Mackensen A | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 8 | Development of a disease-specific quality of life questionnaire for children & adolescents with idiopathic thrombocytopenic purpura(itp-qol)显示文摘 | VON MACKENSEN S NILSSON C JANKOVIC M | 2006 | Pediatr Blood Cancer2006，47，： | 1 |
| 9 | Neurological injury during cardiopulmonary bypass in the rat 显示文摘 | Mackensen GB Newman MF | 2001 | Perfusion2001，16，1： | 1 |
| 10 | Devel- opment and testing of an instrument to assess the Quality of Life of Children with Haemophilia in Europe (Haemo- QoL) 显示文摘 | Mackensen S Bullinger M HAEMOQOL Group | 2004 | Haemophilia2004，10，1： | 1 |
| 11 | Neurological injury during cardiopulmonary bypass in the rat显示文摘 | Grocott HP Mackensen GB Newman MF | 2001 | Perfusion2001，16，1： | 1 |
| 12 | Ocular changes during pregnancy 显示文摘 | Mackensen F Paulus WE Max R | 2014 | Dtsch Arztebl Int2014，34，： | 1 |
| 13 | Randomized, double-blinded,placebo controlled study of neuroprotection with lidocaine in cardiac surgery 显示文摘 | Mathew JP Mackensen GB Phillips-Bute B | 2009 | Stroke2009，40，3： | 1 |
| 14 | Neurological injury during cardiopulmonary bypass in the rat显示文摘 | Grocott HP Mackensen GB Newman MF | | 0，，01： | 1 |
| 15 | Postoperative cognitive deficits:more questions than answers显示文摘 | Mackensen GB Gelb AW | | 0，，02： | 1 |
| 16 | Mice over expressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia显示文摘 | Sheng H Kudo M Mackensen GB | 2000 | Experimental Neurology2000，163，2： | 1 |
| 17 | Induction of tumorspecific cytotoxic T lymphocytes by immunization with autologous tumor cells and interleukin-2 gene transfected fibroblasts显示文摘 | Mackensen A Veelken H Lahn M | 1997 | J Mol Med1997，75，： | 1 |
| 18 | Presence of IgE antibodies to bovine serum albumin in a patient developing anaphylaxis after vaccination with human peptide-pulsed den- dritic cells 显示文摘 | Mackensen A Drager R Schlesier M | 2000 | Cancer hnmunol Immunother2000，49，3： | 1 |
| 19 | Develop- ment and validation of a new questionnaire for the assessment of sub- jective physical performance in adult patients with haemophilia-the HEP- Test- Q 显示文摘 | VON MACKENSEN S CZEPA D HERBSLEB M | 2010 | Haemophilia2010，16，： | 1 |
| 20 | Den- dritic cells for specific cancer immunotherapy 显示文摘 | MEIDENBAUER N ANDREESEN R MACKENSEN A | 2001 | Biol Chem2001，382，4： | 1 |
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