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| 1 | Primary malignant melanoma of the esophagus:A case report显示文摘The authors present the clinical case of an 87-year-old Caucasian male admitted to the emergency room with hematemesis. He had a history of intermittent dys-phagia during the previous month. Endoscopic evaluation revealed an eccentric,soft esophageal lesionlocated 25-35 cm from the incisors,which appeared asa protrusion of the esophagus wall,with active bleeding. Biopsies were acquired. Tissue evaluation wascompatible with a melanoma. After excluding other sites of primary neoplasm,the definitive diagnosis of Primary Malignant Melanoma of the Esophagus(PMME) was made. The patient developed a hospital-acquired respiratory infection and died before tumor-directed treatment could begin. Primary malignant melanoma represents only 0.1% to 0.2% of all esophageal ma-lignant tumors. Risk factors for PMME are not defined.A higher incidence of PMME has been described in Japan. Dysphagia,predominantly for solids,is the most frequent symptom at presentation. Retrosternal orepigastric discom fort or pain,melena or hemate mesishave also been described. The characteristic endoscopic finding of PMME is as a polypoid lesion,with variablesize,usually pigmented. The neoplasm occurs in thelower two-thirds of the esophagus in 86% of cases.PMME metastasizes via hematogenic and lymphatic pathways. At diagnosis,50% of the patients present with distant metastases to the liver,the mediastinum,the lungs and the brain. When possible,surgery(curative or palliative) ,is the preferential method of treatment. There are some reports in the literature where chemotherapy,chemohormon otherapy,radiotherapy and immunotherapy,with or without surgery,wereused with variable efficacy. The prognosis is poor;themean survival after surgery is less than 15 mo. | Joana Machado Paula Ministro Ricardo Araújo Eugénia Cancela António Castanheira Américo Silva | 2011 | World Journal of Gastroenterology2011，17，42： | 6 |
| 2 | Protective effects of an inhibitor of glycoprotein Ⅱb/Ⅲa in the hepatic and pulmonary disturbances secondary to ischemia and reperfusion injury of rats liver显示文摘 | Canedo LF Machado MAC Coelho AM | 2007 | Arquivos de Gastroenterologia2007，44，3： | 1 |
| 3 | The diffusion of technological knowledge through interlaced networks显示文摘 | Leonardo Costa Ribeiro Ricardo Machado Ruiz Eduardo da Motta e Albuquerque Américo T. Bernardes | 2010 | Computer Physics Communications2010，，9： | 1 |
| 4 | NAFLD, NASH and liver canc- er显示文摘 | Michelotti GA Machado MV Diem AM | 2013 | Nat Rev Gastroenterol Hepatol2013，10，11： | 1 |
| 5 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 6 | GLUT4content decreases along with insulin resistance and highlevels of inflammatory markers in rats with metabolicsyndrome显示文摘 | Leguisamo NM Lehnen AM Machado UF | 2012 | Cardiovasc Diabetol2012，11，： | 1 |
| 7 | Gastric carcinoma exhibits distinct types of cell differentiation: an immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1,MUC2,MUC5AC, and MUC6) 显示文摘 | Nogucira AM Carneiro F | 2000 | J Pathol2000，190，4： | 1 |
| 8 | Saliva composition and functions: a comprehensive review显示文摘 | De Almeida Pdel V Gregio AM Machado MA | 2008 | J Contemp Dent Pract2008，9，3： | 1 |
| 9 | Influence of pancreatic enzyme content on experimental acute pancreatitis 显示文摘 | Coelho AM Machado MC Cunha JE | 2003 | Pancreas2003，26，3： | 1 |
| 10 | Totally laparoscopic hepatic bisegmentectomy (s4b + s5) and hilar lymphadenectomy for incidental gallbladder cancer 显示文摘 | Machado AM Makdissi FF Surjan RC | 2015 | Ann Surg Oncol2015，22，3： | 1 |
| 11 | The inhi-bitory effect of an arginine bicarbonate/calcium carbonateCaviStat -containing dentifrice on the development ofdental caries in Venezuelan school children 显示文摘 | Acevedo AM Machado C Rivera LE | 2005 | J ClinDent2005，16，3： | 1 |
| 12 | Midterm and long-term results of percutaneous endovascular treatment of venous outflow obstruction after pediatric liver transplantation 显示文摘 | Carnevale FC Machado AT Moreira AM | 2008 | J Vasc Interv Radiol2008，19，10： | 1 |
| 13 | NAFLD, NASH and liver cancer显示文摘 | Michelotti GA Machado MV Diehl AM | 2013 | Nat Rev Gastroenterol Hepatol2013，10，11： | 1 |
| 14 | A muhicentre, prospective study to evaluate costs of septic patients in Brazilian intensive care units显示文摘 | Sogayar AM Machado FR Rea NA | 2008 | Pharmacoecouomics2008，26，： | 1 |
| 15 | Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease显示文摘 | Machado MP Rocha AM de Oliveira LF | 2012 | Exp Physiol2012，97，11： | 1 |
| 16 | Surgery for adrenal tumours with thrombus in the supra- diaphragmatic infraatrial inferior vena cava, with no cardiopulmonary bypass显示文摘 | Lucon AM Machado MCC Pereira MA | 2004 | BJU International2004，94，1： | 1 |
| 17 | New approach for diagnosis of candidemia based on detection of a 65-kilodalton antigen 显示文摘 | Berzaghi R Colombo AL Machado AM | 2009 | Clin Vaccine Immunol2009，16，11： | 1 |
| 18 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 19 | Surgical endodontic re- intervention using a modern technique: 2 case reports 显示文摘 | Machado R Vansan LP Cruz AM | 2013 | Gen- eral Dentistry2013，62，5： | 1 |
| 20 | Treatment ofankylosing spondylitis with TNF blockers: a meta-analysis 显示文摘 | Machado MA Barbosa MM Almeida AM | 2013 | Rheumatol Int2013，33，： | 1 |
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