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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Immunotherapy for de novo renal transplantation :what's in the pipeline? 显示文摘 | TEDESCO SILVA H JR PINHEIRO MACHADO P ROSSO FELIPE C | 2006 | Drugs2006，66，13： | 1 |
| 4 | CO2 assimilation, photosynthetic light response curves, and water relations of 'Pera' sweet orange plants infected with Xylella fastidiosa显示文摘 | Habermann G Machado E C Rodrigues J D | 2003 | Braz J Plant Physiol2003，15，2： | 1 |
| 5 | Synthesis of Na A and-X zeolites from oil shale ash 显示文摘 | Machado N R C F Miotto D M M | 2005 | Fuel2005，84，： | 1 |
| 6 | Study of physiological parameters for the selection of maize genotypes efficient in ammonium uptake 显示文摘 | MAGALHAES J R PURCINO A A C MACHADO A T | 1990 | Documentos EmpresaCapixaba de Pesquisa Agropecuaria1990，65，： | 1 |
| 7 | ATlblockade during lactation as a model of chronic nephropathy:mechanisms of renal injury 显示文摘 | Machado FG Poppi EP Fanelli C | 2008 | Am J Physiol Renal Physiol2008，294，6： | 1 |
| 8 | Probing the mechanism of the Heck reaction with arene diazonium salts by electrospray mass and tandem mass spectrometry 显示文摘 | SABINO A A MACHADO A H L ROQUE C D | 2004 | Angew Chem Int Ed2004，43，19： | 1 |
| 9 | In vitro activity of Brazilian medicinal plants,naturally occurring naphthoquinones and their analogues,against methicillin-resistant staphylococcus aureus显示文摘 | MACHADO T B PINTO A V PINTO M C | 2003 | Int J Antimicrob Ag2003，21，3： | 1 |
| 10 | Analysis of the Consumption of Artistic- cultural Goods and Services in Brazil 显示文摘 | Diniz S C Machado A F | 2011 | Journal of Cultural Eco- nomics2011，35，1： | 1 |
| 11 | Osmotic response in Lactobacillus casei ATCC 393:biochemical and biophysical characteristics of membrane显示文摘 | Machado M C Lopez C S Heras H | 2004 | Arch Biochem Biophy2004，422，： | 1 |
| 12 | A distribu- ted concurrency control mechanism for XML data 显示文摘 | Moreura L O SOUSA F R C MACHADO J C | 2011 | Journal of Compute and System Science2011，38，9： | 1 |
| 13 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 14 | ApoB genehaplo type is associated with lipid profile of higher risk forcoronary heart disease in Caucasian Brazilian men 显示文摘 | Machado M O H irata M H Bertolami M C | 2001 | J Clin LabAnal2001，15，1： | 1 |
| 15 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 16 | Floating photocatalysts based on TiO2 supported on high surface area exfoliated vermiculite for water decontamination显示文摘 | Machado L C R Torchia C B Lago R M | 2006 | Catal Com2006，7，： | 1 |
| 17 | Cost- effectiveness of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus显示文摘 | Machado A R L Arns C C Follador W | 2005 | Braz J lnfect Dis2005，9，3： | 1 |
| 18 | Catalytic growth of carbon nanofibers on Cr nanoparticles on a carbon substrate:adsorbents for organic dyes in water显示文摘 | de Oliveira L C da Silva A C Machado A R T | | 0，，05： | 1 |
| 19 | Different expression levels of alpha3/4 fucosyhransferases and Lewis determinants in ovarian carcinoma tissues and cell lines 显示文摘 | Escrevente C Machado E Brito C | 2006 | Int J Oncol2006，29，3： | 1 |
| 20 | Extraction of lemongrass essential oil with dense carbon dioxide显示文摘 | Carlson L H C Machado R A F Spricigo C B | 2001 | J Supercrit Fluids2001，21，： | 1 |
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